June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Macular vascular microcirculation in the ganglion cell-inner plexiform layer in glaucoma patients of African and European descent using optical coherence tomography angiography
Karine D Bojikian; Logan Taylor; Hoon Jung; Joanne Wen; Zhongdi Chu; Xiao Zhou; Qinqin Zhang; Raghu C Mudumbai; Murray A Johnstone; Ruikang K Wang; Philip P Chen
Author Affiliations & Notes
  • Karine D Bojikian
    Ophthalmology, University of Washington, Seattle, Washington, United States
  • Logan Taylor
    School of Medicine, University of Washington, Washington, United States
  • Hoon Jung
    Ophthalmology, University of Washington, Seattle, Washington, United States
  • Joanne Wen
    Department of Ophthalmology, Duke Universiry, North Carolina, United States
  • Zhongdi Chu
    Department of Bioengineering, University of Washington, Washington, United States
  • Xiao Zhou
    Department of Bioengineering, University of Washington, Washington, United States
  • Qinqin Zhang
    Department of Bioengineering, University of Washington, Washington, United States
  • Raghu C Mudumbai
    Ophthalmology, University of Washington, Seattle, Washington, United States
  • Murray A Johnstone
    Ophthalmology, University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    Department of Bioengineering, University of Washington, Washington, United States
    Ophthalmology, University of Washington, Seattle, Washington, United States
  • Philip P Chen
    Ophthalmology, University of Washington, Seattle, Washington, United States
  • Footnotes
    Commercial Relationships   Karine Bojikian, None; Logan Taylor, None; Hoon Jung, None; Joanne Wen, None; Zhongdi Chu, None; Xiao Zhou, None; Qinqin Zhang, None; Raghu Mudumbai, None; Murray Johnstone, None; Ruikang Wang, Carl Zeiss Meditec Inc. (F), Oregon Health & Science University (P); Philip Chen, None
  • Footnotes
    Support  Research to Prevent Blindness (New York, NY)
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3909. doi:
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      Karine D Bojikian, Logan Taylor, Hoon Jung, Joanne Wen, Zhongdi Chu, Xiao Zhou, Qinqin Zhang, Raghu C Mudumbai, Murray A Johnstone, Ruikang K Wang, Philip P Chen; Macular vascular microcirculation in the ganglion cell-inner plexiform layer in glaucoma patients of African and European descent using optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3909.

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Abstract

Purpose : To investigate the differences in the macular vascular microcirculation in eyes with open angle glaucoma of African descent (AD) and European descent (ED) using optical coherence tomography-angiography (OCTA).

Methods : Twenty-eight OAG eyes of AD and 56 OAG eyes of ED were scanned using AngioPlex OCTA system (Zeiss Meditec Inc., Dublin, CA) and macular vascular microcirculation was measured by calculating the overall flux and vessel area density (VAD) over the entire 6mm x 6mm area excluding the large retinal vessels. Two-sample, independent t-tests were used to compare the macular blood flow metrics between AD and ED eyes. Linear regression models were used to investigate the correlation between macular blood flow metrics and structural and functional parameters.

Results : There was no significant difference in age, sex, intraocular pressure, number of glaucoma medications, cup-to-disc ratio, RNFL thickness and visual field (VF) mean deviation (MD) and VF pattern standard deviation (PSD) between AD and ED eyes included (adjusted p ≥ 0.377). Although more AD patients had diagnosis of systemic hypertension and were taking higher number of anti-hypertensive medications (adjusted p = 0.048), there was no difference in detected systolic BP, diastolic BP, and mean ocular perfusion pressure (p>0.377). Eyes of AD and ED had similar GICPL flux (4.697 ± 1.067 for AD vs 5.148 ± 1.358 for ED; p=0.161) and GCIPL VAD (0.071 ± 0.013 for AD vs 0.072 ±0.015 for ED; p=0.915). Additionally, macular blood flow metrics were significantly correlated with VF MD, VF PSD and RNFL thickness (p≤0.012) (Table 1).

Conclusions : No significant differences were found in macular microcirculation as detected by OCTA between AD and ED eyes. Macular microcirculation metrics were significantly correlated with disease severity in AD and ED glaucomatous eyes.

This is a 2020 ARVO Annual Meeting abstract.

 

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