June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
A wide field swept source optical tomography angiography analysis of the relationship between diabetic macular ischemia and peripheral perfusion
Author Affiliations & Notes
  • Ying Zhu
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
    Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China
  • Ying Cui
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Jay Wang
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Yifan Lu
    Harvard Medical School, Boston, Massachusetts, United States
  • Rebecca Zeng
    Boston University School of Medicine, Boston, Massachusetts, United States
  • Raviv Katz
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • David M Wu
    Ophthalmology, Wilmer Eye Institute, Baltimore, Maryland, United States
  • Dean Eliott
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Demetrios G Vavvas
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Deeba Husain
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Joan W Miller
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Leo A Kim
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • John B Miller
    Ophthalmology, Massachusetts Eye and Ear Infirmary , Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Ying Zhu, None; Ying Cui, None; Jay Wang, None; Yifan Lu, None; Rebecca Zeng, None; Raviv Katz, None; David Wu, None; Dean Eliott, None; Demetrios Vavvas, None; Deeba Husain, None; Joan Miller, None; Leo Kim, None; John Miller, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4101. doi:
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    • Get Citation

      Ying Zhu, Ying Cui, Jay Wang, Yifan Lu, Rebecca Zeng, Raviv Katz, David M Wu, Dean Eliott, Demetrios G Vavvas, Deeba Husain, Joan W Miller, Leo A Kim, John B Miller; A wide field swept source optical tomography angiography analysis of the relationship between diabetic macular ischemia and peripheral perfusion. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4101.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Macular ischemia is an important factor related with visual impairment in patients with diabetic retinopathy, however the risk factors remain unknown. The present study investigated the possible relationship between macular ischemia and peripheral perfusion with a wide field swept source OCTA (SS-OCTA).

Methods : We conducted a prospective, observational study in Mass Eye and Ear from December 2018 to October 2019. Patients with only one eye diagnosed with macular ischemia were included and the fellow eye served as control. All patients were imaged with a SS-OCTA (PLEX® Elite 9000; Carl Zeiss Meditec, Inc, Dublin, CA). The diagnosis of macular ischemia was based on Angio 6mm×6mm images and calculations were done with Angio 12mm×12mm images. Vessel density (VD), skeleton density (SD) and ischemia index (ISI, summed area of non perfusion areas divided by total area) of superficial retina were calculated using Image J (NIH). All statistic analyses were performed using SPSS software 22.0 (SPSS Inc, Chicago, IL) and paired t-test was used for comparison between groups.

Results : Twenty-two eyes (11 eyes with macular ischemia and the fellow eye without macular ischemia) were included in the study. The average superficial VD and SD were similar between the ischemia group and control group (VD 0.487±0.061 vs. 0.493±0.057, SD 0.144±0.023 vs. 0.148±0.024, P>0.05). The ISI of the ischemia group was higher than control, but this did not reach statistical significance either (0.126±0.118 vs. 0.096±0.088, P>0.05).

Conclusions : Diabetic macular ischemia was not directly related to peripheral perfusion of superficial retina on Angio 12mm×12mm.

This is a 2020 ARVO Annual Meeting abstract.

 

OCTA images of the two eyes from the same patient. The left eye had diabetic macular ischemia and the right eye served as control. There were no statistically significant difference in peripheral perfusion between the two eyes on Angio 12mm ×12mm.

OCTA images of the two eyes from the same patient. The left eye had diabetic macular ischemia and the right eye served as control. There were no statistically significant difference in peripheral perfusion between the two eyes on Angio 12mm ×12mm.

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