June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Comparing retinal thickness and Matrix 10-2 functional testing in diabetic macular edema
Author Affiliations & Notes
  • Bhim Bahadur Rai
    JCSMR, Australian National University., Mawson, Australian Capital Territory, Australia
  • Ted Maddess
    JCSMR, Australian National University., Mawson, Australian Capital Territory, Australia
  • Corinne F Carle
    JCSMR, Australian National University., Mawson, Australian Capital Territory, Australia
    Neuroscience, ANU Medical School, Canberra, Australian Capital Territory, Australia
  • Emilie Marie Frances Rohan
    JCSMR, Australian National University., Mawson, Australian Capital Territory, Australia
  • Joshua P van Kleef
    JCSMR, Australian National University., Mawson, Australian Capital Territory, Australia
  • Rohan W Essex
    Ophthalmology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia
    Ophthalmology, ANU Medical School, Canberra, Australian Capital Territory, Australia
  • Christopher J Nolan
    Endocrinology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia
    Endocrinology, ANU Medical School, Canberra, Australian Capital Territory, Australia
  • Faran Sabeti
    JCSMR, Australian National University., Mawson, Australian Capital Territory, Australia
    Optometry School, University of Canberra, Canberra, Australian Capital Territory, Australia
  • Footnotes
    Commercial Relationships   Bhim Rai, None; Ted Maddess, Konan Medical USA Inc (F), Konan Medical USA Inc (P), Konan Medical USA Inc (I); Corinne Carle, Konan Medical USA Inc (F), Konan Medical USA Inc (I), Konan Medical USA Inc (P); Emilie Rohan, None; Joshua van Kleef, None; Rohan Essex, None; Christopher Nolan, None; Faran Sabeti, Konan Medical USA Inc (F)
  • Footnotes
    Support  Australian Research Council through the ARC Centre of Excellence in Vision Science (CE0561903), intramural funding from the ANU, and an ANU PhD scholarship to BB Rai.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4866. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Bhim Bahadur Rai, Ted Maddess, Corinne F Carle, Emilie Marie Frances Rohan, Joshua P van Kleef, Rohan W Essex, Christopher J Nolan, Faran Sabeti; Comparing retinal thickness and Matrix 10-2 functional testing in diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4866.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Diabetic macular edema (DME) is commonly managed based upon visual acuity (VA) and retinal thickness. But the patients with early-stage off-centre macular edema and good visual acuity also had significant central sensitivity loss, suggesting we should more often include functional testing in our decision making for the treatment. We conducted this study to do point-by-point comparisons of OCT macular thickness and Matrix 10-2 data in early off-centre DME.

Methods : We tested both eyes of 23 Type-2 diabetes (T2D) patients with mild off-centre DMO in at least one eye. Matrix 10-2 perimetry, with its 2x2 degree stimuli, assessed the function. Spectralis 8x8 macular thickness grid data was mapped to the 44 10-2 regions to allow point-by-point structure-function analysis (see attached Figure). We also collected the standard ETDRS retinal thickness data.

Results : Of 23 patients, 14 were males. The mean age was 60.6 ± 9.7 years, diabetes duration 11.4 ± 7.7 years, HbA1c 7.62 ± 1.43, and ETDRS VA 82.5 ± 6.5 (20/25). The median Martrix MD and PSD were -14.7 and 6.0 (median p=0.005). Central maximum thickness was 320 ± 27 um. For the central 16 10-2 points for left and right eyes, of thicker and thinner than median thickness locations, the correlation with sensitivity ranged from 0.07 ± 0.16 to -0.38 ± 0.25, only 9 of 44 (18.8%) correlations being significant. Stepwise linear models found that BCVA was determined mainly by Matrix MD and ETDRS retinal thinness variables for 3 and 6 degrees, but not central thickness (OS and OD r2= 0.84 and 0.85). Pearson correlations between BCVA and Matrix MD, PSD, and central, 3 and 6 degree ETDRS thicknesses, only showed significant correlation with Matrix MD (r= -0.58, p<e-5).

Conclusions : Despite significant sensitivity loss there was little correlation with increased retinal thickness due to DME, suggesting functional loss preceded the structural change. Surprisingly BCVA was mainly determined by off-axis thickness and average 10-2 sensitivity loss, and not central thickness. Functional testing may be useful in diagnosing early complications even before structural and clinical changes.

This is a 2020 ARVO Annual Meeting abstract.

 

A) Median retinal thickness of left eyes, mapped onto the Matrix grid. B) Median Matrix sensitivities. C) Correlations between sensitivity and thickness, > abs(0.45) is significant.

A) Median retinal thickness of left eyes, mapped onto the Matrix grid. B) Median Matrix sensitivities. C) Correlations between sensitivity and thickness, > abs(0.45) is significant.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×