June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Plexus-specific detection of retinal capillary nonperfusion in neovascular age-related macular degeneration with projection-resolved OCT angiography.
Author Affiliations & Notes
  • Liqin Gao
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
    Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, China
  • Jie Wang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
    Department of Biomedical Engineering, Oregon Health & Science University,, Oregon, United States
  • Qisheng You
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Yukun Guo
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Thomas S Hwang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Brandon J Lujan
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • David Huang
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Yali Jia
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
    Department of Biomedical Engineering, Oregon Health & Science University,, Oregon, United States
  • Steven T Bailey
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Liqin Gao, None; Jie Wang, None; Qisheng You, None; Yukun Guo, None; Thomas Hwang, None; Brandon Lujan, None; David Huang, Optovue (F), Optovue (I), Optovue (P), Optovue (R); Yali Jia, Optovue (F), Optovue (P); Steven Bailey, Optovue (F)
  • Footnotes
    Support  National Institutes of Health (R01EY027833, R01EY024544, P30 EY010572); William & Mary Greve Special Scholar Award and unrestricted departmental funding from Research to Prevent Blindness (New York, NY).
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1808. doi:
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      Liqin Gao, Jie Wang, Qisheng You, Yukun Guo, Thomas S Hwang, Brandon J Lujan, David Huang, Yali Jia, Steven T Bailey; Plexus-specific detection of retinal capillary nonperfusion in neovascular age-related macular degeneration with projection-resolved OCT angiography.. Invest. Ophthalmol. Vis. Sci. 2020;61(7):1808.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Histopathological studies have demonstrated nonfunctional retinal capillaries in eyes with nAMD. The purpose of the study is to compare the plexus-specific retinal capillary nonperfusion with projection-resolved OCT angiography (PR-OCTA) in eyes with nAMD compared to healthy control eyes.

Methods : In this cross-sectional study, eyes with treatment-naÏve nAMD underwent macular 3x3-mm OCTA with AngioVue system. OCTA scans were analyzed and processed including 3-dimensional projection artifact removal, retinal layer semi-automated segmentation, and en face angiogram generation. Automated quantification of retinal total avascular area (TAA) and extrafoveal (excluding the central 1-mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP), and deep capillary plexus (DCP) respectively. The TAA and EAA on each of the three plexuses was compared between eyes with nAMD and healthy age-matched controls using Mann-Whitney U test.

Results : The clinical characteristics of 24 eyes with nAMD and 16 controls eyes are summarized in table 1. Compared to control eyes, nAMD eyes had significantly larger total avascular area (TAA) in SVC (median 0.442 vs. 0.273 mm2, P=0.01) and DCP (0.363 vs. 0.207 mm2, P=0.003), and only mildly larger TAA in ICP (0.260 vs.0.206 mm2, P=0.092) [Fig.1]. EAAs in nAMD eyes were significantly larger in SVC (median 0.149 vs. 0.042 mm2, P<0.001), ICP (0.018 vs. 0.000 mm2, P=0.002), and DCP (0.039 vs. 0.000 mm2, P<0.001) compared with the control eyes.

Conclusions : PR-OCTA showed that nAMD is associated with focal nonperfusion in all retinal vascular plexuses.

This is a 2020 ARVO Annual Meeting abstract.

 

Table1. Clinical Characteristics of Study Participants with Neovascular Age-Related Macular Degeneration and Age-Matched Controls.

Table1. Clinical Characteristics of Study Participants with Neovascular Age-Related Macular Degeneration and Age-Matched Controls.

 

Fig.1 Eyes with neovascular age-related macular degeneration have greater areas of nonperfusion (labeled as blue areas) compared to age-matched healthy controls.

Fig.1 Eyes with neovascular age-related macular degeneration have greater areas of nonperfusion (labeled as blue areas) compared to age-matched healthy controls.

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