Abstract
Purpose :
The Crowd-Sourced Glaucoma Study (CSGS) is a large international collaborative effort that aims to identify objective visual field (VF) and optical coherence tomography (OCT) criteria that match the assessment of glaucoma likelihood by multiple glaucoma specialists. We report the first phase of the study, which was creating a database of patient examinations.
Methods :
We invited investigators to join the study group and provide patient data to the CSGS by using an email discussion group of investigators interested in new glaucoma definitions and by using networking contacts, aiming to be geographically diverse. Collaborating investigators randomly or consecutively selected patients from glaucoma or general ophthalmology clinics to be included in the CSGS. Patients with pathologies other than open angle glaucoma or with unreliable examinations were excluded. For each patient, 3 examinations of 1 eye were included: an optic disc photograph, a VF examination (program 24-2 or G1) and an OCT examination with neuroretinal rim, peripapillary retinal nerve fibre layer thickness, and macular ganglion cell analysis.
Results :
We included 1270 patients from 22 centres in 15 countries. The median (interquartile range) number of patients per centre was 45 (33 - 71). The geographic distribution of patients was: 441 (35%) from the Americas, 338 (27%) from Europe, 318 (25%) from Asia, 130 (10%) from Oceania, and 43 (3%) from Africa. The OCT device used was Cirrus for 616 (49%), Spectralis for 570 (45%), iScan for 43 (3%), and RS-3000 for 41 (3%) of the patients. The VF device used was Humphrey Field Analyser (HFA) for 1114 (88%) and Octopus for 156 (12%) of the patients. The mean (standard deviation) patient age was 61.0 (13.6) years. Patients covering the complete spectrum of VF damage were included (HFA mean deviation: median -2.1 dB, range -32.1 to 2.6; Octopus mean defect: median 1.7 dB, range -2.1 to 20.7; Fig. 1).
Conclusions :
A large and diverse patient database was created for the CSGS. In the next phase of the study, multiple glaucoma specialists globally will be invited to evaluate patient examinations and provide their assessment of the glaucoma likelihood.
This is a 2020 ARVO Annual Meeting abstract.