June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Quantitative Assessment of Choriocapillaris in Patients with Diabetic Retinopathy: A Swept-Source Optical Coherence Tomography Angiography Study
Author Affiliations & Notes
  • Yining Dai
    University of Washington, Seattle, Washington, United States
  • Hao Zhou
    University of Washington, Seattle, Washington, United States
  • Qinqin Zhang
    University of Washington, Seattle, Washington, United States
  • Zhongdi Chu
    University of Washington, Seattle, Washington, United States
  • Jennifer R Chao
    University of Washington, Seattle, Washington, United States
  • Kasra A. Rezaei
    University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    University of Washington, Seattle, Washington, United States
  • Footnotes
    Commercial Relationships   Yining Dai, None; Hao Zhou, None; Qinqin Zhang, None; Zhongdi Chu, None; Jennifer Chao, None; Kasra Rezaei, None; Ruikang Wang, Carl Zeiss Meditec, Inc. (C), Carl Zeiss Meditec, Inc. (F), Insight Photonic Solutions (C), Insight Photonic Solutions (P), Kowa (C), Tasso (F)
  • Footnotes
    Support  NH Grant (R01EY028753), Grant from the Carl Zeiss Meditec, and an unrestricted grant from the Research to Prevent Blindness, Inc., New York, NY
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2725. doi:
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      Yining Dai, Hao Zhou, Qinqin Zhang, Zhongdi Chu, Jennifer R Chao, Kasra A. Rezaei, Ruikang K Wang; Quantitative Assessment of Choriocapillaris in Patients with Diabetic Retinopathy: A Swept-Source Optical Coherence Tomography Angiography Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2725.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To quantify flow deficits (FDs) in the submacular choriocapillaris (CC) in patients with diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA).

Methods : Diabetic patients with different stages of DR and normal subjects were imaged with SS-OCTA instrument (PLEX Elite 9000, Carl Zeiss Meditec, Dublin, California, USA) using the 6x6-mm macular scan pattern. The CC images were generated using previously published and validated algorithms. The percentage of FDs (FD%) and the average size of FDs were measured in a 5-mm-diameter circular region centered on the fovea in CC.

Results : Forty-five eyes from 45 patients with different stages of DR and 27 eyes from 27 age-matched nondiabetic controls were enrolled in this study. Overall, the CC FD% in patients with DR was 1.4-fold greater than that in control subjects (12.34% ± 4.14% vs 8.82% ± 2.61%, P < 0.001); the mean FD size was 1.4-fold larger in patients with DR than that in control subjects (2151.3 ± 650.8 µm2 vs 1574.4 ± 255.0 µm2, P < 0.001). No significant difference in FD% or mean FD size was observed between patients with nonproliferative DR and patients with proliferative DR in the submacular CC (P = 1.000 and P = 1.000, respectively).

Conclusions : Submacular CC perfusion is significantly decreased in patients with DR compared with age-matched nondiabetic controls. CC visualization and quantification using SS-OCTA may help improve the current understanding of pathogenesis, progression, and treatment response of diabetic eye disease.

This is a 2020 ARVO Annual Meeting abstract.

 

Figure. Exemplary illustration of enface SS-OCTA images from a control eye and eyes with different stages of diabetic retinopathy. (A–D) 61-year-old normal subject. (E–H) 62-year-old patient with nonproliferative diabetic retinopathy. (I–L). 60-year-old patient with proliferative diabetic retinopathy. (A, E, I) Enface retinal blood flow image. (B, F, J) Enface choriocapillaris flow image without artifacts removal. (C, G, K) Corresponding choriocapillaris flow deficits (green color) overlaid onto the choriocapillaris flow image (gray) after artifacts subtraction. (D, H, L) Choriocapillaris flow deficits binary map for quantification where the marks are given for a 5-mm-diameter circular region (yellow) centered on the fovea. All images are 6×6-mm fields.

Figure. Exemplary illustration of enface SS-OCTA images from a control eye and eyes with different stages of diabetic retinopathy. (A–D) 61-year-old normal subject. (E–H) 62-year-old patient with nonproliferative diabetic retinopathy. (I–L). 60-year-old patient with proliferative diabetic retinopathy. (A, E, I) Enface retinal blood flow image. (B, F, J) Enface choriocapillaris flow image without artifacts removal. (C, G, K) Corresponding choriocapillaris flow deficits (green color) overlaid onto the choriocapillaris flow image (gray) after artifacts subtraction. (D, H, L) Choriocapillaris flow deficits binary map for quantification where the marks are given for a 5-mm-diameter circular region (yellow) centered on the fovea. All images are 6×6-mm fields.

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