June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Visual outcomes following cataract surgery in geographic atrophy patients in routine clinical practice
Author Affiliations & Notes
  • Chandruganesh Rasendran
    Case Western Reserve School of Medicine, Cleveland Heights, Ohio, United States
  • Alexander Haueisen
    Case Western Reserve School of Medicine, Cleveland Heights, Ohio, United States
  • Andrew Xie Chen
    Case Western Reserve School of Medicine, Cleveland Heights, Ohio, United States
    Center for Opthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States
  • Grant L Hom
    Case Western Reserve School of Medicine, Cleveland Heights, Ohio, United States
    Center for Opthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States
  • Thais Conti
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
    Center for Opthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States
  • Tyler Greenlee
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
    Center for Opthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States
  • Isaac Briskin
    Department for Quantitative Health Sciences, Lerner Research Institute, Cleveland, Ohio, United States
  • Rishi P Singh
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
    Center for Opthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States
  • Katherine Talcott
    Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, United States
    Center for Opthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, United States
  • Footnotes
    Commercial Relationships   Chandruganesh Rasendran, None; Alexander Haueisen, None; Andrew Chen, None; Grant Hom, None; Thais Conti, None; Tyler Greenlee, None; Isaac Briskin, None; Rishi Singh, Alcon/Novartis (C), Apellis (F), Bausch + Lomb (C), Genentech/Roche (C), Graybug (F), Opthea (C), Regeneron Pharmaceutigals, Inc (C), Zeiss (C); Katherine Talcott, Zeiss (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3386. doi:
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      Chandruganesh Rasendran, Alexander Haueisen, Andrew Xie Chen, Grant L Hom, Thais Conti, Tyler Greenlee, Isaac Briskin, Rishi P Singh, Katherine Talcott; Visual outcomes following cataract surgery in geographic atrophy patients in routine clinical practice. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3386.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Few studies have assessed visual outcomes, including prognostic variables, of cataract surgery in patients with geographic atrophy (GA) in the setting of age-related macular degeneration. This study aims to determine visual acuity (VA) outcomes of cataract surgery in patients with fovea-involving GA and to assess the prognostic value of baseline ocular and systemic characteristics.

Methods : This retrospective cohort study compared patients with fovea-involving GA to age- and baseline VA-matched control patients undergoing cataract surgery from 2015-2017 at the Cleveland Clinic. VA and optical coherence tomography (OCT) data including central subfield thickness (CST) and retinal pigment epithelium (RPE) sub-illumination area within 5 mm of foveal center were collected at pre-operative, post-operative month 1 (POM1), and post-operative month 12 (POM12) visits. POM12 VA was the primary outcome measure.

Results : Thirty-five eyes with fovea-involving GA and 31 controls were included. GA and control groups were similar in terms of baseline VA (37.3±19.5 and 45.1±12.6 ETDRS letters, respectively, p=0.06), age (79.3±6.8 and 77.6±4.1 years, respectively, p=0.11), and proportion of smokers or former smokers (77.1% and 58.1%, respectively, p=0.10). At POM12, the GA cohort had no significant change in VA from baseline (+2.1 ± 17.3 letters, p=0.68), while the control cohort experienced a significant gain in VA (+30.0±12.9 letters, p<0.01). GA area, as represented by RPE sub-illumination area based upon SDOCT, did not change between baseline and 12 months when adjusting for baseline size (5.7 vs. 6.1 mm2, p=0.78). Baseline VA (p=0.007) and CST (p=0.015) were significant predictors of change in VA at POM12, and were negatively and positively associated, respectively. Age at surgery and GA area at baseline were not significant predictors.

Conclusions : Cataract surgery may provide marginal benefit to VA in fovea-involving GA, but may still offer visual benefits not measured by VA and should be considered on a case-by-case basis.

This is a 2020 ARVO Annual Meeting abstract.

 

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