June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Inter-Eye Intraocular Pressure Asymmetries in Different Glaucoma Subtypes
Author Affiliations & Notes
  • Hui Wang
    Institute for Psychology and Behavior, Jilin University of Finance and Economics, Changchun, Jilin, China
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Mengyu Wang
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Lucy Shen
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Dian Li
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Raymond C S Wong
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Yangjiani Li
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Eun Young Choi
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Nathan Eli Hall
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Qingying Jin
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Joan W Miller
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Alice Lorch
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Tobias Elze
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Hui Wang, None; Mengyu Wang, None; Lucy Shen, None; Dian Li, None; Raymond C S Wong, None; Yangjiani Li, None; Eun Young Choi, None; Nathan Hall, None; Qingying Jin, None; Lucia Sobrin, None; Joan Miller, Genentech/Roche (C), Genentech/Roche (R), KalVista Pharmaceuticals (C), Lowy Medical Research Institute (F), ONL Therapeutics (C), ONL Therapeutics (P), ONL Therapeutics (I), ONL Therapeutics (R), Sunovion (C), Valeant Pharmaceuticals/Mass. Eye and Ear (P), Valeant Pharmaceuticals/Mass. Eye and Ear (R); Alice Lorch, None; Tobias Elze, None
  • Footnotes
    Support  NIH R21 EY030142, R21 EY030631, R01 EY030575, K99 EY028631, P30 EY003790, BrightFocus Foundation, Grimshaw-Gudewicz Foundation, Research to Prevent Blindness, Lions Foundation, Alice Adler Fellowship
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4762. doi:
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    • Get Citation

      Hui Wang, Mengyu Wang, Lucy Shen, Dian Li, Raymond C S Wong, Yangjiani Li, Eun Young Choi, Nathan Eli Hall, Qingying Jin, Lucia Sobrin, Joan W Miller, Alice Lorch, Tobias Elze; Inter-Eye Intraocular Pressure Asymmetries in Different Glaucoma Subtypes. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4762.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Previous studies reported intraocular pressure (IOP) asymmetries for single types of glaucoma as well as systematic lateral IOP differences. We aimed to quantify inter-eye differences and asymmetries of IOP in different glaucoma subtypes.

Methods : We extracted the available IOP measurements of both eyes from about 60 million patients in the American Academy of Ophthalmology’s IRIS® Registry dataset. When data for multiple visits were available, the most recent one was selected. Patients were separated by ICD-10 code into patients with glaucomatous conditions (codes H40.*) and non-glaucoma patients (absence of H40 codes). We compared the inter-eye IOP differences for the most prevalent subtypes of glaucomatous conditions including ocular hypertension, primary open-angle glaucoma (POAG), low-tension glaucoma (LTG), pigmentary glaucoma, pseudoexfoliation glaucoma, acute angle-closure glaucoma (AACG), chronic angle-closure glaucoma (CACG), and glaucoma secondary to eye trauma, inflammation and medications. T-test was performed to test if there was a systematic difference between the two eyes. Mean absolute inter-eye IOP differences were calculated to quantify the IOP asymmetry.

Results : Table 1 shows the detailed results. Approximately 15.5 million non-glaucoma patients and 2.8 million glaucoma patients with the aforementioned 10 glaucoma subtypes were selected for data analyses. The five most prevalent glaucomatous subtypes were POAG, ocular hypertension, LTG, CACG, and pseudoexfoliation glaucoma. The mean IOP of the left eye was almost identical to the mean IOP of the right eye for all subgroups, except that the left eye IOPs of non-glaucoma, LTG and pseudoexfoliation glaucoma were significantly slightly higher than the right eye IOPs. The mean absolute inter-eye IOP differences were highest for glaucoma secondary to eye trauma and inflammation (4.95 and 4.39 mmHg), followed by AACG, CACG, glaucoma secondary to medications, pseudoexfoliation glaucoma, pigmentary glaucoma, ocular hypertension and POAG (3.88, 3.20, 3.08, 2.79, 1.96, 1.95 and 1.94 mmHg), which were higher than than non-glaucoma (1.11 mmHg). The inter-eye IOP difference for LTG was in a similar range (1.17 mmHg) of non-glaucoma.

Conclusions : While systematic laterality effects were negligible, inter-eye IOP differences for different glaucoma subtypes ranged from 1.17 to 4.95 mmHg, which may imply distinct etiologies.

This is a 2020 ARVO Annual Meeting abstract.

 

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