June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Long-Term Outcomes of Micropulse Transscleral Cyclophotocoagulation in Primary Open-Angle Glaucoma and the Effect of Preoperative Intraocular Pressure
Author Affiliations & Notes
  • Agni Kakouri
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
    Ophthalmology, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois, United States
  • Nicholas Maxwell Pfahler
    Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, United States
  • Brett Breshears
    Midwestern University, Batavia, Illinois, United States
  • Thomas Patrianakos
    Ophthalmology, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois, United States
  • Michael Giovingo
    Ophthalmology, John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois, United States
    Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Footnotes
    Commercial Relationships   Agni Kakouri, None; Nicholas Pfahler, None; Brett Breshears, None; Thomas Patrianakos, None; Michael Giovingo, Iridex Corp (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 5235. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Agni Kakouri, Nicholas Maxwell Pfahler, Brett Breshears, Thomas Patrianakos, Michael Giovingo; Long-Term Outcomes of Micropulse Transscleral Cyclophotocoagulation in Primary Open-Angle Glaucoma and the Effect of Preoperative Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 2020;61(7):5235.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To compare 1-year outcomes of micropulse transscleral cyclophotocoagulation (MP-CPC) in terms of IOP, number of IOP-lowering agents, and surgical success between primary open-angle glaucoma (POAG) patients with high and low preoperative (preop) IOP.

Methods : A retrospective chart review was performed of POAG patients undergoing MP-CPC at John H. Stroger Hospital of Cook County, Chicago, IL from 2015 to 2019. The study included 125 eyes from 99 patients. IOP and the number of IOP-lowering agents were recorded at each follow-up visit through 12 months. High and low IOP was defined as >21 and ≤21 mmHg, respectively. Kaplan-Meier survival analyses were conducted with failure defined as IOP ≤ 5 or > 21 or a reduction ≤ 20% on two consecutive study visits without additional glaucoma intervention. Eyes that succeeded with additional intervention were classified as a qualified success. Logrank tests were used to compare survival curves between groups.

Results : Out of 125 eyes, 62 (49.6%) were classified as high preop IOP and 63 (50.4%) were classified as low preop IOP. Fifty-two eyes (41.6%) had previous glaucoma intervention, which was not associated with surgical success in survival analysis (p=0.58). After 12 months, mean IOP was reduced from 30.7±7.6 to 15.7±6.0 (p<0.0001) in eyes with high preop IOP and from 18.0±2.1 to 14.9±3.7 (p=0.0004) in those with low preop IOP (Fig. 1). The number of IOP-lowering agents decreased in eyes with both high (p=0.02) and low (p=0.002) preop IOP with no difference between groups. The probability of success was significantly higher for eyes with high preop IOP (p=0.01). After 12 months, success probabilities were 43.5% and 28.7% for eyes with high and low preop IOP, respectively (Fig. 2). Qualified success probabilities after 12 months were 49.2% and 30.6%. The odds ratio for surgical failure after 12 months was 2.2 (p=0.04) for patients with low compared with high preop IOP. When additional intervention during the follow-up period was not considered, the odds ratio rose to 2.8 (p=0.006).

Conclusions : MP-CPC is effective at decreasing IOP and the need for IOP-lowering agents in POAG patients. However, patients with preop IOP > 21 had a significantly higher probability of achieving surgical success after 12 months than those with preop IOP ≤ 21. Preop IOP may be useful in predicting successful MP-CPC outcomes.

This is a 2020 ARVO Annual Meeting abstract.

 

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×