Abstract
Purpose :
To topographically compare the locations of the 24-2, 24-2C and 10-2 test locations to the region of arcuate defects seen on optical coherence tomography (OCT) retinal ganglion cell (RGC) probability maps.
Methods :
The OCT RGC plus inner plexiform layer (RGC+) probability maps of 110 eyes [1,2] with “early” glaucoma (24-2 MD better than -6dB) were examined for the presence of central (±8°)/macular arcuate defects (Fig. 1A). 42 of these eyes had central superior field, inferior retinal arcuate defects within the central ±8°, as in Fig. 1A. The superior test locations of the 24-2, 24-2C, and 10-2 within ±8° were superimposed on the RGC+ map (Fig. 1A) and the number of VF locations falling on the abnormal (Yellow and Red) regions counted. In addition, the 8 locations (24-2E points), based upon the paper[3] that suggested adding 10-2 points to 24-2 pattern, was also assessed.
Results :
On average, 1.1 of the two 10-2 points shared with the 24-2 VF fell within the abnormal OCT region (Table, col. 1). As expected, this increased as the number of 10-2 points added increased, from 2.4 for the 5 additional 24-2C points to 4.8 for the 30 points in the superior 10-2 within ±8°; and the % of the abnormal 10-2 points (Abn10-2%) included increased as well (Table, col. 2). To obtain an estimate of the value added per point (Table, col 3), Abn10-2% (col 2) was divided by n, the number of 10-2 points included in each test. The value added per point was lowest, 3.21% per point, for the 5 24-2C points, and highest, 4.29%, for the 8 24-2E points. The 24-2E values were significantly greater than the 24-2C ones. Fig. 1B shows the number of the 42 eyes with abnormal RGC+ regions per location. Notice that 3 of the 5 24-2C points involve locations that are abnormal in fewer eyes than are 6 of the 8 24-2E points.
Conclusions :
Given the variation in arcuate damage to the macula across individuals, no single pattern of 5 points, as in the 24-2C, will be optimal for all eyes. For a particular patient, selecting additional points based upon the individual’s RGC+ probability map may work better. 1. Hood, De Cuir et al., TVST 2016; 2. Hood, Tsamis et al., IOVS, 2019. 3. Ehrlich, Raza et al., TVST 2014.
This is a 2020 ARVO Annual Meeting abstract.