June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
The clinical observation of tuberculosis sclerosis (TSC) involving the optic disc in children
Author Affiliations & Notes
  • Wei Shi
    ophthalmology, Beijing Children's Hospital, Beijing, China
  • Li Li
    ophthalmology, Beijing Children's Hospital, Beijing, China
  • Dayong Bai
    ophthalmology, Beijing Children's Hospital, Beijing, China
  • Chunxia Peng
    ophthalmology, Beijing Children's Hospital, Beijing, China
  • Footnotes
    Commercial Relationships   Wei Shi, None; Li Li, None; Dayong Bai, None; Chunxia Peng, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2137. doi:
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    • Get Citation

      Wei Shi, Li Li, Dayong Bai, Chunxia Peng; The clinical observation of tuberculosis sclerosis (TSC) involving the optic disc in children. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2137.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To observe the clinical characteristics of tuberculosis sclerosis (TSC) involving the optic disc in children.

Methods : Seven children with TSC involving the optic disc were subjected to fundus, infrared fundus photography (IFG), optical coherence tomography (OCT), skull CT or MRI examination.All of them were diagnosed as TSC by clinical genetic testing. And all relevant data were retrospectively analyzed.

Results : 1) The ratio of male to female was 1: 1 and the average age 2.4 ± 2.2 years; 2) One or more yellow-and-white worm-like lesions were found in the fundus of the 7 cases, most of which were located in the posterior central retina, and some lesions occurred in the peripheral of optic disc; 3) OCT examination showed that the tumor-like lesions of all cases were occurred in the nerve fiber layer; 4) The electrophysiological examination of 4 cases showed either light adaptation conditions or the dark adaptation conditions, the amplitudes of a and b wave were decreased; 5) The orbit CT examination revealed calcification in the lesion; 6) Intracranial MRI showed that the intracranial lesions were subventricular and cerebral cortical nodular with low or equal density ,and the enhanced MRI showed the lesions were reinforced.

Conclusions : 1) Most of the lesions involving the optic disc are located in the optic nerve fiber layer, which are mainly membranous in early stages. As the disease progressing, hierarchical calcification may occur, and calcified tumor-like lesions can also occur in some cases; 2) OCT examination combined with imaging examination can be helpful for the diagnosis of TSC.

This is a 2020 ARVO Annual Meeting abstract.

 

Figures A and B show that both optic disc were affected by hamartoma
Figures C and D: IFG scan
Figures E and F: OCT scan, E shows: dashed arrows show worm plaques, and F shows vitreous cortex pulling above the optic disc of the left eye.

Figures A and B show that both optic disc were affected by hamartoma
Figures C and D: IFG scan
Figures E and F: OCT scan, E shows: dashed arrows show worm plaques, and F shows vitreous cortex pulling above the optic disc of the left eye.

 

The image above shows a round-like lesion above the optic disc in the left eye
and the Orbital CT scan below shows calcification at the lesion

The image above shows a round-like lesion above the optic disc in the left eye
and the Orbital CT scan below shows calcification at the lesion

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