Abstract
Purpose :
To observe the clinical characteristics of tuberculosis sclerosis (TSC) involving the optic disc in children.
Methods :
Seven children with TSC involving the optic disc were subjected to fundus, infrared fundus photography (IFG), optical coherence tomography (OCT), skull CT or MRI examination.All of them were diagnosed as TSC by clinical genetic testing. And all relevant data were retrospectively analyzed.
Results :
1) The ratio of male to female was 1: 1 and the average age 2.4 ± 2.2 years; 2) One or more yellow-and-white worm-like lesions were found in the fundus of the 7 cases, most of which were located in the posterior central retina, and some lesions occurred in the peripheral of optic disc; 3) OCT examination showed that the tumor-like lesions of all cases were occurred in the nerve fiber layer; 4) The electrophysiological examination of 4 cases showed either light adaptation conditions or the dark adaptation conditions, the amplitudes of a and b wave were decreased; 5) The orbit CT examination revealed calcification in the lesion; 6) Intracranial MRI showed that the intracranial lesions were subventricular and cerebral cortical nodular with low or equal density ，and the enhanced MRI showed the lesions were reinforced.
Conclusions :
1) Most of the lesions involving the optic disc are located in the optic nerve fiber layer, which are mainly membranous in early stages. As the disease progressing, hierarchical calcification may occur, and calcified tumor-like lesions can also occur in some cases; 2) OCT examination combined with imaging examination can be helpful for the diagnosis of TSC.
This is a 2020 ARVO Annual Meeting abstract.