June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Comparison of Reading Speed Tests in Geographic Atrophy
Author Affiliations & Notes
  • Audrey Kapre
    Genentech, Inc., South San Francisco, California, United States
  • Daniela Ferrara
    Genentech, Inc., South San Francisco, California, United States
  • Elizabeth Tschosik
    Genentech, Inc., South San Francisco, California, United States
  • Chin-Yu Lin
    Genentech, Inc., South San Francisco, California, United States
  • Sobha Sivaprasad
    Moorfields Eye Hospital, London, United Kingdom
  • Footnotes
    Commercial Relationships   Audrey Kapre, Genentech, Inc. (E); Daniela Ferrara, Genentech, Inc. (E); Elizabeth Tschosik, Genentech, Inc. (E); Chin-Yu Lin, Genentech, Inc. (E); Sobha Sivaprasad, Bayer (F), Bayer (C), Boehringer (C), Boehringer Ingelheim (F), Heidelberg Engineering (C), Novartis (F), Novartis (C), Optos (C), Oxurion (F), Oxurion (C), Roche (F), Roche (C)
  • Footnotes
    Support  F. Hoffmann-La Roche, Ltd., Basel, Switzerland, provided financial support for the study and participated in the study design; conduct of the study; collection, management, analysis, and interpretation of the data
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2990. doi:
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    • Get Citation

      Audrey Kapre, Daniela Ferrara, Elizabeth Tschosik, Chin-Yu Lin, Sobha Sivaprasad; Comparison of Reading Speed Tests in Geographic Atrophy. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2990.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate the relationship between maximum reading speed (MRS) scores derived from 2 widely used reading speed tests in order to assess correlation and interchangeability.

Methods : Patients from English-speaking countries (United States, United Kingdom, Australia; N = 81), with bilateral geographic atrophy (GA) and no choroidal neovascularization, who were enrolled in a natural history study, Proxima A (NCT02479386), were asked to complete 2 different reading speed tests at baseline and month 12: the Minnesota Low-Vision Reading Test (MNRead) and Radner Reading Chart. The results of the reading tests were analyzed for correlation between results: MRS score in words per minute (wpm; monocular and binocular) and change from baseline in MRS (monocular and binocular).

Results : Patients had a mean (SD) age of 81.3 (6.9) years, 63% were female, and 95% were white. Functional and anatomic characterization of the study eye at baseline was characterized as follows. Mean (SD) best-corrected visual acuity, low-luminance visual acuity, and low-luminance deficit were 66.3 (9.1), 33.3 (18.0), and 33.0 (17.0) letters, respectively. Mean (SD) GA area was 7.67 (3.84) mm2; 79.2% of patients had multifocal lesions, and 48.1% of patients had subfoveal lesions. Mean (SD) distance to central fovea for non-subfoveal GA was 240.3 (195.6) µm. Results from the 2 reading speed tests at baseline and follow up were compared as follows. The monocular MRS scores derived from the MNRead and Radner Reading Chart were highly correlated at baseline (n = 78, r=0.88) and month 12 (n = 48, r = 0.76; Figures 1 and 2). Binocular MRS scores were also highly correlated between the 2 assessments at baseline (n = 80, r = 0.87) and month 12 (n = 50, r = 0.89). Change from baseline on the 2 reading speed charts were moderately correlated for binocular MRS (n = 50, r = 0.57), and monocular MRS (n = 48, r = 0.43).

Conclusions : The results demonstrate a strong correlation in MRS data obtained from the MNRead and Radner Reading Chart, both for monocular and binocular tests, at baseline and month 12. Due to early study termination, only ~60% of patients had month 12 assessments. More research will be needed to better understand the relationship between changes in the 2 reading speed tests over time.

This is a 2020 ARVO Annual Meeting abstract.

 

Correlation between the MNRead and Radner Reading Chart for monocular MRS at baseline.

Correlation between the MNRead and Radner Reading Chart for monocular MRS at baseline.

 

Correlation between the MNRead and Radner Reading Chart for monocular MRS at month 12.

Correlation between the MNRead and Radner Reading Chart for monocular MRS at month 12.

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