June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Multi modal and multi scale retinal imaging with and without adaptive optics for clinical settings
Author Affiliations & Notes
  • Muhammad Faizan Shirazi
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wien, Austria
  • Jordi Andilla
    ICFO-The Institute of Photonic Sciences, Spain
  • Marina Cunquero
    ICFO-The Institute of Photonic Sciences, Spain
  • Nicolas Lefaudeux
    Imagine Eyes, France
  • Danilo Andrade De Jesus
    Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
  • Luisa Sanchez Brea
    Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
  • Stefan Klein
    Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
  • Theo van Walsum
    Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
  • Kate Grieve
    Centre Hospitalier National d‘Ophtalmologie des Quinze-Vingts, France
  • Michel Paques
    Centre Hospitalier National d‘Ophtalmologie des Quinze-Vingts, France
  • Michael Larsen
    Rigshospitale, Denmark
  • Pablo Loza
    ICFO-The Institute of Photonic Sciences, Spain
  • Xavier levecq
    Imagine Eyes, France
  • Nicolas Chateau
    Imagine Eyes, France
  • Michael Pircher
    Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Wien, Austria
  • Footnotes
    Commercial Relationships   Muhammad Shirazi, None; Jordi Andilla, None; Marina Cunquero, None; Nicolas Lefaudeux, S.A. IMAGINE EYES (E); Danilo Andrade De Jesus, None; Luisa Sanchez Brea, None; Stefan Klein, None; Theo van Walsum, None; Kate Grieve, None; Michel Paques, None; Michael Larsen, None; Pablo Loza, None; Xavier levecq, S.A. IMAGINE EYES (E); Nicolas Chateau, S.A. IMAGINE EYES (E); Michael Pircher, IMAGINE EYES (C)
  • Footnotes
    Support  MERLIN EU-HORIZON 2020 ICT
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3243. doi:
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      Muhammad Faizan Shirazi, Jordi Andilla, Marina Cunquero, Nicolas Lefaudeux, Danilo Andrade De Jesus, Luisa Sanchez Brea, Stefan Klein, Theo van Walsum, Kate Grieve, Michel Paques, Michael Larsen, Pablo Loza, Xavier levecq, Nicolas Chateau, Michael Pircher; Multi modal and multi scale retinal imaging with and without adaptive optics for clinical settings. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3243.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To introduce a compact multi modal and multi scale retinal imaging instrument and to investigate its imaging performance.

Methods : The system consists of two imaging modes, scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) that are operated simultaneously. The field of view of both imaging modes can be switched between a standard large field of view mode and a narrow field of view mode for cellular resolution imaging using adaptive optics (AO) correction of ocular aberrations. The SLO channel is additionally used for retinal tracking of the OCT mode by real time compensation of retinal motion. The SLO is operated at a central wavelength of 790nm and records 13 images per second. The swept source OCT is operated at 1060nm with an A-scan rate of 200kHz that is translated to a B-scan rate of 200Hz with an axial resolution of 7µm in tissue. The AO correction is operated in closed loop at 10Hz. The retinal tracker correction is operated at 200Hz. The entire instrument has a compact design (~350mm x 300mm x 500mm) and the scanning head is mounted on motorized translation stages that enable 3D tracking of the pupil position. In post processing, an averaged SLO or AO-SLO image can be used as ground truth for fine registration of OCT image data.

Results : Images recorded in healthy volunteers with the large field of view mode show comparable quality as obtained with commercial systems. The attached figure shows representative image data recorded with the instrument. Images recorded with the high resolution AO-SLO mode show individual cone photoreceptors. Similarly, the high axial resolution of the AO-OCT allows for a clear separation between the layers of the photoreceptor/RPE-complex.

Conclusions : The multi modal approach enables a more precise registration of OCT image frames. The multi scale approach allows for a rapid identification of regions of interest in the large field of view mode and for a more detailed analysis in the high resolution mode.

This is a 2020 ARVO Annual Meeting abstract.

 

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