June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
High Speed Volumetric Intrasurgical Optical Coherence Tomography at 400 kHz with Real Time, 4D Visualization of Surgical Maneuvers
Author Affiliations & Notes
  • Christian Viehland
    Duke Univeristy, Durham, North Carolina, United States
  • Jianwei David Li
    Duke Univeristy, Durham, North Carolina, United States
  • Al-Hafeez Dhalla
    Duke Univeristy, Durham, North Carolina, United States
  • William Raynor
    Duke Univeristy, Durham, North Carolina, United States
  • Lejla Vajzovic
    Duke Univeristy, Durham, North Carolina, United States
  • Anthony N Kuo
    Duke Univeristy, Durham, North Carolina, United States
  • Cynthia Toth
    Duke Univeristy, Durham, North Carolina, United States
  • Joseph A Izatt
    Duke Univeristy, Durham, North Carolina, United States
  • Footnotes
    Commercial Relationships   Christian Viehland, None; Jianwei Li, None; Al-Hafeez Dhalla, Beyeonics (C), Leica Microsystems (P); William Raynor, None; Lejla Vajzovic, Alcon (C); Anthony Kuo, Leica Microsystems (P); Cynthia Toth, Alcon (R), EMMES (C), Hemosonics (R); Joseph Izatt, Carl Zeiss Meditec (P), Carl Zeiss Meditec (R), Leica Microsystems (P), Leica Microsystems (R), St Jude Medical (P), St Jude Medical (R)
  • Footnotes
    Support  NIH 5U01 EY028079-02, NIH P30 EY005722
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3244. doi:
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      Christian Viehland, Jianwei David Li, Al-Hafeez Dhalla, William Raynor, Lejla Vajzovic, Anthony N Kuo, Cynthia Toth, Joseph A Izatt; High Speed Volumetric Intrasurgical Optical Coherence Tomography at 400 kHz with Real Time, 4D Visualization of Surgical Maneuvers. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3244.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Ophthalmic microsurgery is typically performed through a stereoscopic operating microscope which provides limited depth perception. Microscope integrated OCT (MIOCT) can augment the surgeon’s view by providing high resolution, depth resolved imaging. However, most previously reported MIOCT systems use 100 kHz or slower OCT engines, limiting these systems to B-scan imaging or slow (~3 Hz) volumetric imaging. This limits their utility for surgical guidance as the former lacks lateral context and the latter is too slow to capture dynamic surgical maneuvers. In order to facilitate real time, 4D guidance of surgery we have developed a new, high speed 4D MIOCT system based on a 400 kHz laser.

Methods : A commercially available Enfocus MIOCT scanner was modified for high speed swept source OCT. The OCT engine used a 400 kHz, 1050 nm swept frequency laser. Light from the laser was introduced into modified scanner and illuminated a transmissive Mach-Zender interferometer. A Truevision (Goleta, CA) 3D visualization system was used to provide heads up, stereoscopic visualization of both the surgical field and OCT data on a 3D TV. Optical power on the sample was below 5.5 mW in accordance with ANSI Z80.36 standard for 1050 nm light.

Results : High Speed MIOCT imaging was performed using a 300 A-scan/B-scan, 180 inactive lines per B-scan, and 96 B-scans/volume scanning protocol (8.68 Hz volume rate). MIOCT images were acquired during mock surgical maneuvers performed with a membrane scraper in ex-vivo porcine eyes. The increased volume rate enables the surgeon to monitor the tool tissue interaction and manipulate the pockets of sub-retinal fluid using 4D MIOCT guidance only.

Conclusions : We have demonstrated a real time 4D MIOCT system for visualization of mock surgical maneuvers. Based on these results we believe this system will be readily translated into human surgery.

This is a 2020 ARVO Annual Meeting abstract.

 

Fig.1 Left: Modified scanner (red star) during a mock surgical procedure and the surgeon’s view of the TrueVision 3D display (yellow star) showing the surgical video (left half on the screen) and the 4D OCT (right half of the screen). Right: Excerpts from a 4D MIOCT sequence showing two subretinal cysts (red and yellow arrows) being manipulated by a membrane scraper (blue arrow). Using MIOCT guidance the surgeon was able to manipulate the pockets of sub-retinal fluid such that they combined (purple arrow).

Fig.1 Left: Modified scanner (red star) during a mock surgical procedure and the surgeon’s view of the TrueVision 3D display (yellow star) showing the surgical video (left half on the screen) and the 4D OCT (right half of the screen). Right: Excerpts from a 4D MIOCT sequence showing two subretinal cysts (red and yellow arrows) being manipulated by a membrane scraper (blue arrow). Using MIOCT guidance the surgeon was able to manipulate the pockets of sub-retinal fluid such that they combined (purple arrow).

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