June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Hemiretinal Asymmetry in Optical Coherence Tomography Angiography Parameters in Healthy, Glaucoma Suspect, and Glaucoma Eyes of the African American Eye Disease Study
Author Affiliations & Notes
  • Kendra Hong
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Anna L. Urrea
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Bruce Burkemper
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Ryuna Chang
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Jae Chang Lee
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Zhongdi Chu
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Xiao Zhou
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Ruikang K Wang
    Bioengineering, University of Washington, Seattle, Washington, United States
  • Rohit Varma
    Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, United States
  • Grace Marie Richter
    Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Kendra Hong, None; Anna Urrea, None; Bruce Burkemper, None; Ryuna Chang, None; Jae Lee, None; Zhongdi Chu, None; Xiao Zhou, None; Ruikang Wang, Carl Zeiss Meditec (C), Carl Zeiss Meditec (P), Carl Zeiss Meditec (F); Rohit Varma, None; Grace Richter, Carl Zeiss Meditec (F)
  • Footnotes
    Support  NIH Grant 5K23EY027855-03, NIH Grant U10EY023575, an unrestricted grant to the USC Department of Ophthalmology from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3917. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Kendra Hong, Anna L. Urrea, Bruce Burkemper, Ryuna Chang, Jae Chang Lee, Zhongdi Chu, Xiao Zhou, Ruikang K Wang, Rohit Varma, Grace Marie Richter; Hemiretinal Asymmetry in Optical Coherence Tomography Angiography Parameters in Healthy, Glaucoma Suspect, and Glaucoma Eyes of the African American Eye Disease Study. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3917.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Glaucomatous damage often starts focally in one hemisphere. This study investigates hemiretinal asymmetry in peripapillary optical coherence tomography angiography (OCTA) parameters in healthy, glaucoma suspect, and glaucoma eyes and its ability to detect early glaucomatous damage in the African American Eye Disease Study (AFEDS).

Methods : 4135 eyes from 2127 African Americans 40 years and older in Inglewood, California received 6x6-mm optic disc scans on spectral-domain OCTA. Custom software quantified vessel diameter (VD), vessel area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI), vessel complexity index (VCI), flow impairment zone (FIZ), and flux. Circumpapillary retinal nerve fiber layer (RNFL) thickness was measured from OCT scans. 711 eyes met inclusion/exclusion criteria. Two age- and sex-matched groups were constructed: 1) 260 healthy and 87 glaucoma suspect eyes, and 2) 95 healthy and 34 glaucoma eyes. Hemiretinal asymmetry (hVD, hVAD, hVSD, hVPI, hVCI, hFIZ, and hFlux) was defined as absolute difference between superior and inferior hemiretinal values. Diagnostic ability was evaluated with area under the receiver operating curve (AUC). A linear discriminant function (LDF) was constructed with all hemiretinal asymmetry and global OCTA parameters.

Results : Glaucoma suspect eyes had significantly higher hemiretinal asymmetry in OCTA parameters than healthy eyes: hVD (p = 0.007), hVAD (p = 0.028), hVSD (p < .0001), hVPI (p < .0001), and hFIZ (p = 0.011). Based on AUC, hemiretinal asymmetry in OCTA parameters was better at detecting glaucoma suspect than global OCTA parameters: hVD (0.623), hVAD (0.577), hVSD (0.640), hVPI (0.759), hVCI (0.559), and hFIZ (0.579). While glaucoma eyes had significantly higher hemiretinal asymmetry in some OCTA parameters than healthy eyes, global OCTA parameters were better at detecting glaucoma than hemiretinal asymmetry based on AUC: VD (0.767), VAD (0.813), VSD (0.807), VPI (0.814), VCI (0.814), FIZ (0.785), and flux (0.800) (Table 1). LDF yielded the highest AUC for glaucoma suspect (0.805) and glaucoma (0.889).

Conclusions : Hemiretinal asymmetry in OCTA parameters was better than global OCTA parameters at distinguishing glaucoma suspect eyes from healthy eyes, but this advantage was not seen in detecting glaucoma eyes, where damage becomes more diffuse.

This is a 2020 ARVO Annual Meeting abstract.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×