June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
The Impact of Smoking on the Incidence of Different Glaucoma-Related Conditions
Author Affiliations & Notes
  • Mengyu Wang
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Dian Li
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Eun Young Choi
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Raymond C S Wong
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Yangjiani Li
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Nathan Eli Hall
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Hui Wang
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Qingying Jin
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Lucia Sobrin
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Joan W Miller
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Alice Lorch
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Tobias Elze
    Department of Ophthalmology, Schepens Eye Research Institute of Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Mengyu Wang, None; Dian Li, None; Eun Young Choi, None; Raymond C S Wong, None; Yangjiani Li, None; Nathan Hall, None; Hui Wang, None; Qingying Jin, None; Lucia Sobrin, None; Joan Miller, Genentech/Roche (C), Genentech/Roche (R), KalVista Pharmaceuticals (C), ONL Therapeutics (R), ONL Therapeutics (C), ONL Therapeutics (P), ONL Therapeutics (I), Sunovion (C), Valeant Pharmaceuticals/Mass. Eye and Ear (P, R) Lowy Medical Research Institute (F); Alice Lorch, None; Tobias Elze, None
  • Footnotes
    Support  NIH K99 EY028631, NIH R21 EY030142, NIH R21 EY030631, NIH R01 EY030575, NIH P30 EY003790, BrightFocus Foundation, Grimshaw-Gudewicz Foundation, Research to Prevent Blindness, Lions Foundation, Alice Adler Fellowship.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4558. doi:
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    • Get Citation

      Mengyu Wang, Dian Li, Eun Young Choi, Raymond C S Wong, Yangjiani Li, Nathan Eli Hall, Hui Wang, Qingying Jin, Lucia Sobrin, Joan W Miller, Alice Lorch, Tobias Elze; The Impact of Smoking on the Incidence of Different Glaucoma-Related Conditions. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4558.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To study the impact of smoking on the incidence of different glaucoma-related conditions.

Methods : From the American Academy of Ophthalmology IRIS® Registry with about 60 million ophthalmic patients in the US, we extracted the most recent available smoking history for glaucoma (ICD-10 codes H40.*) and non-glaucoma patients of at least 18 years of age. The smoking history was coded into three categories including never, former and current smokers. We compared the disease incidence rates for 13 glaucoma-related conditions including anatomical narrow angle (ANA), steroid responder, ocular hypertension, primary open-angle glaucoma (POAG), low-tension glaucoma (LTG), pigmentary glaucoma, pseudoexfoliation (PXF) glaucoma, acute angle-closure glaucoma (AACG), chronic angle-closure glaucoma (CACG), intermittent angle-closure glaucoma (IACG), and glaucoma secondary to eye trauma, inflammation and medications. Chi-squared test was used to test if the disease prevalence was higher for ever smokers than never smokers. P values were corrected for multiple comparisons.

Results : Approximately 9.85 million non-glaucoma patients and 1.23 million glaucoma patients were selected. The five glaucoma-related conditions with the highest percentages of current smokers (Table 1) were glaucoma secondary to eye trauma (17.6%), AACG (13.0%), glaucoma secondary to eye trauma (12.5%), pigmentary glaucoma (11.6%) and ocular hypertension (10.1%) compared with non-glaucoma (9.5%). The five glaucoma-related conditions with the highest percentages of former smokers (Table 1) were PXF glaucoma (27.1%), LTG (25.4%), steroid responder (24.8%), POAG (23.6%) and AACG (23.3%) compared with non-glaucoma (18.7%). All 13 glaucoma-related conditions except IACG and glaucoma secondary to medications in ever smokers (Table 2) had significantly higher prevalence compared with never smokers with risk ratios ranging from 1.69 (Glaucoma secondary to eye trauma) to 1.10 (ANA). The top five glaucoma-related conditions with the highest risk ratios were glaucoma secondary to eye trauma (1.69), AACG (1.43), glaucoma secondary to eye inflammation (1.36), steroid responder (1.28) and PXF glaucoma (1.28). The risk ratio of POAG in ever smokers to never smokers was 1.17.

Conclusions : Compared with never smokers, patients with a smoking history had increased risk to have glaucoma-related conditions with risk ratios ranging from 1.69 to 1.10 in IRIS Registry.

This is a 2020 ARVO Annual Meeting abstract.

 

 

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