June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Spatial Relation between Hyperreflective Foci and Vascular Network in Eyes with Cystoid Macular Edema
Author Affiliations & Notes
  • Toco Yuen Ping Chui
    Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Davis Zhou
    Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Maria Virginia Castanos Toral
    Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States
  • Reilly L. Allison
    Graduate School of Biomedical Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
  • Rachel E Linderman
    Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
  • Joseph Carroll
    Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
    Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
  • Richard B Rosen
    Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, New York, United States
    Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
  • Footnotes
    Commercial Relationships   Toco Chui, None; Davis Zhou, None; Maria Castanos Toral, None; Reilly Allison, None; Rachel Linderman, OptoVue (C); Joseph Carroll, AGTC (F), MeiraGTx (C), MeiraGTx (F), OptoVue (F), Translational Imaging Innovations (I); Richard Rosen, Astellas (C), Bayer (C), Boehringer-Ingelheim (C), Genentech-Roche (C), GlaucoHealth (I), Guardion (I), NanoRetina (C), OD-OS (C), Opticology (I), OptoVue (C), OptoVue (P), Regeneron (C), Teva (C)
  • Footnotes
    Support  This study was supported by the National Eye Institute of the National Institutes of Health under award numbers R01EY027301, R01EY024969 and P30EY001931. Additional funding for this research was provided by the Marrus Family Foundation, the New York Eye and Ear Infirmary Foundation and the Jorge N. Buxton Microsurgical Foundation.
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 4810. doi:
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    • Get Citation

      Toco Yuen Ping Chui, Davis Zhou, Maria Virginia Castanos Toral, Reilly L. Allison, Rachel E Linderman, Joseph Carroll, Richard B Rosen; Spatial Relation between Hyperreflective Foci and Vascular Network in Eyes with Cystoid Macular Edema. Invest. Ophthalmol. Vis. Sci. 2020;61(7):4810.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Hyperreflective foci (HF) on OCT images may be associated with retinal inflammatory responses and represent activated microglia or lipoprotein exudation.a,b Using volume rendering of OCT-reflectance (OCT-R) and OCT-angiography (OCT-A), we evaluated the spatial relation between HF and the neighboring vascular network in eyes with cystoid macular edema.

Methods : Seven patients with cystoid macular edema due to diabetic retinopathy, retinal vein occlusion, or hemangioblastomas were imaged using a clinical SD-OCT system (Avanti RTVue-XR; Optovue). Ten 3x3mm scans centered at the fovea were obtained and averaged. OCT-R (Fig. A) showing the structural features (e.g. HF and cystoid spaces) and OCT-A (Fig. B) showing the perfused vasculature were flattened at the Bruch’s membrane and merged into a single volume using ImageJ (NIH, MD, USA). To better visualize the spatial relation between HF, cystic structures, and vascular network, the merged OCT-R and OCT-A volume was 3-D rendered (Fig. C) using MIPAV (Medical Image Processing, Analysis, and Visualization, NIH, MD, USA).c

Results : Diffused and/or clustered HF were identified in all patients with cystoid macula edema. Distinct HF were found within the walls of cystic structures and within the cystoid spaces (Fig. C). Relatively weak OCT-A signal underneath the locations with HF aggregation was observed due to shadowing effect. Perivascular HF were identified around both perfused and non-perfused blood vessels.

Conclusions : We demonstrated three-dimensional observation of HF, cystic structures, and vascular network using a merged OCT-R and OCT-A volume. Assessing spatial relation between these structural and examining associated functional abnormalities may provide insight on the pathophysiology of cystoid macular edema and its progression.
aPMID: 29392317; bPMID: 24386645; cPMID: 26428608

This is a 2020 ARVO Annual Meeting abstract.

 

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