June 2020
Volume 61, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2020
Assessment of Retinal Structural Characteristics in Eyes with Vogt Koyanagi Harada Disease and Macular Edema
Author Affiliations & Notes
  • Mohammad Ali Sadiq
    University of Louisville, Louisville, Kentucky, United States
  • Maria Soledad Ormaechea
    Byers Eye Institute, California, United States
    Hospital Universitario Austral, Buenos Aires, Argentina
  • Muhammad Hassan
    Byers Eye Institute, California, United States
    Saint Mary Mercy Hospital, Livonia, Michigan, United States
  • Sarakshi Mahajan
    Byers Eye Institute, California, United States
  • Gunay Uludag
    Byers Eye Institute, California, United States
  • Ariel Schlaen
    Saint Mary Mercy Hospital, Livonia, Michigan, United States
  • Quan Dong Nguyen
    Byers Eye Institute, California, United States
  • Footnotes
    Commercial Relationships   Mohammad Sadiq, None; Maria Ormaechea, None; Muhammad Hassan, None; Sarakshi Mahajan, None; Gunay Uludag, None; Ariel Schlaen, None; Quan Nguyen, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 2082. doi:
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      Mohammad Ali Sadiq, Maria Soledad Ormaechea, Muhammad Hassan, Sarakshi Mahajan, Gunay Uludag, Ariel Schlaen, Quan Dong Nguyen; Assessment of Retinal Structural Characteristics in Eyes with Vogt Koyanagi Harada Disease and Macular Edema. Invest. Ophthalmol. Vis. Sci. 2020;61(7):2082.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare retinal layer thicknesses in patients with stable Vogt Koyanagi Harada (VKH) disease, VKH with macular edema post resolution, and normal individuals

Methods : Patients with a confirmed diagnosis of stable VKH managed at a tertiary care center between 2009 and 2017 were analyzed. These patients were divided into two groups based on the absence of macular edema (Group 1) and history of resolved macular edema (Group 2). SD-OCT (Heidelberg Spectralis®) was utilized to capture 5-line High Definition (HD) raster scans centered on the foveal center. The semi-automated segmentation tool of the Heyex Software Version 6.2 was utilized to segment the retinal layers into 1) Full Retinal Thickness (FRT); 2) Retinal Nerve Fiber Layer (RNFL); 3) Ganglion Cell Layer (GCL); 4) Inner Plexiform Layer (IPL); 5) Inner Nuclear Layer (INL); 6) Outer Plexiform Layer (OPL); 7) Outer Nuclear Layer (ONL); 8) Photoreceptor Layer (PRL); 9) Retinal Pigment Epithelium (RPE). The average thicknesses of these layers across the 5-line raster scan were also calculated. Similar segmentation and analyses were also performed on 22 normal eyes (11 Patients).

Results : Forty-two eyes (22 patients) with VKH disease were enrolled in the study. 32 eyes were without macular edema and 10 eyes had a history of resolved macular edema. The mean average thicknesses of the segmented layers in the three study groups are shown in Table 1. A significant thinning of the ONL, PRL, and RPE layers was seen in group 2.

Conclusions : Macular edema is an uncommon complication in patients with VKH disease. Our study showed a significant thinning of the ONL, PRL and RPE layers in patients with VKH with macular edema status post resolution, compared to those with stable VKH disease. Chronic inflammation with secondary atrophic changes in the above mentioned retinal layers may be a possible explanation for our findings.

This is a 2020 ARVO Annual Meeting abstract.

 

Mean retinal thicknesses of the different retinal layers across the three study groups

Mean retinal thicknesses of the different retinal layers across the three study groups

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