June 2020
Volume 61, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2020
Contrast-generated illusory motion can be used to evaluate contrast sensitivity changes in patients with retinal vein occlusions
Author Affiliations & Notes
  • Shubhendu Mishra
    Feinberg School of Medicine, Chicago, Illinois, United States
  • Natalie Squires
    Feinberg School of Medicine, Chicago, Illinois, United States
  • Nenita Maganti
    Feinberg School of Medicine, Chicago, Illinois, United States
  • Prithvi Bomdica
    Feinberg School of Medicine, Chicago, Illinois, United States
  • Divya Nigam
    American University, District of Columbia, United States
  • Arthur Shapiro
    Neuroscience, American University, District of Columbia, United States
  • Manjot Gill
    Ophthalmology, Northwestern University, Illinois, United States
  • Alice T Lyon
    Ophthalmology, Northwestern University, Illinois, United States
  • Rukhsana Mirza
    Ophthalmology, Northwestern University, Illinois, United States
  • Footnotes
    Commercial Relationships   Shubhendu Mishra, None; Natalie Squires, None; Nenita Maganti, None; Prithvi Bomdica, None; Divya Nigam, None; Arthur Shapiro, None; Manjot Gill, None; Alice Lyon, None; Rukhsana Mirza, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 3378. doi:
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      Shubhendu Mishra, Natalie Squires, Nenita Maganti, Prithvi Bomdica, Divya Nigam, Arthur Shapiro, Manjot Gill, Alice T Lyon, Rukhsana Mirza; Contrast-generated illusory motion can be used to evaluate contrast sensitivity changes in patients with retinal vein occlusions. Invest. Ophthalmol. Vis. Sci. 2020;61(7):3378.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Patients with retinal diseases commonly have vision changes that cannot be quantified by acuity measurements and imaging data. This study asserts that a more robust understanding of vision changes in retinal diseases can be achieved by analyzing contrast sensitivity (CS). A new tool known as the motion diamond stimulus (MDS) utilizes contrast-generated illusory motion in dynamic test regions to determine contrast sensitivity thresholds. The MDS and the Pelli-Robson were used to quantify vision changes in patients with retinal vein occlusions (RVO). We hypothesize that the MDS, compared to the Pelli-Robson, will reliably measure CS changes, while also quantifying additional aspects of contrast sensitivity.

Methods : In this prospective IRB-approved study, 20 patients with RVO in only 1 eye, who were receiving anti-VEGF treatment and had vision better than 20/40 were recruited. All subjects underwent 3 assessments: the Pelli-Robson, the MDS, and the NEI's VFQ-25. The MDS assessment produced 2 primary data endpoints, α and β, from multiple CS thresholds. The α value represents the overall contrast threshold level and the β value serves as a parameter to quantify the adaptability of the visual contrast system. The CS output parameters from the MDS and log CS Pelli-Robson values were used to compare RVO eyes (n=20) to control eyes (n=20).

Results : The study participants had a mean composite QOL score of 89.5±10.4 on the VFQ-25. A significant difference was observed between the RVO eyes and the control eyes in the Pelli-Robson log CS scores (p-value=0.0001). The MDS also exhibited a significant difference in α value between RVO and control eyes (p-value=0.01). No difference in β value was found between the study groups (p-value=0.39).

Conclusions : The results for the MDS assessment's α parameter corroborated the Pelli-Robson scores, suggesting contrast sensitivity threshold impairment in patients with RVO. No significant difference in β value was observed between study groups, suggesting that adaptability of the visual system is maintained in treated RVO. This may be due to effective anti-VEGF therapy and is supported by high VFQ-25 scores in these patients, but these findings require further study. This study also showed that MDS produces contrast threshold data comparable to the Pelli-Robson, while also providing additional quantitative data regarding CS adaptability.

This is a 2020 ARVO Annual Meeting abstract.

 

 

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