Measurement reproducibility using Vivid Vision Perimetry: a virtual reality-based mobile platform

Abstract

Purpose : Vivid Vision Perimetry (VVP) is a novel method for performing in-office and home-based visual field assessment using a virtual reality platform and oculokinetic perimetry. The purpose of this study was to examine the test-retest reproducibility of the VVP platform.

Methods : Subjects with open-angle glaucoma and glaucoma suspects were prospectively enrolled and underwent visual field analysis across 54 test locations in a 24-2 pattern using the VVP device (Vivid Vision, San Francisco, CA). Each subject was examined in 2 sessions, and the mean sensitivity (dB) was the primary outcome measure obtained for each eye in both sessions. The repeatability of mean sensitivity was assessed through analysis of bias from the differences between the two VVP sessions. A Bland-Altman plot using a mixed effects model (adjusting for average sensitivity and eye correlation) was created to illustrate the level of agreement between repeated measurements.

Results : Fourteen eyes of 7 open-angle glaucoma patients and 10 eyes of 5 glaucoma suspects were enrolled (mean age 62.3 +/- 9.3 years, 33% female). Based on the data from 24 eyes, the average difference of VVP mean sensitivity between the two sessions was found to be 0.48 dB. Three eyes (12.5%) fell outside the upper and lower limits of agreement (95% CI: -1.15, 2.11). The level of agreement between repeated VVP measurements showed a general trend of increasing precision as mean sensitivity values increased (Figure 1).

Conclusions : The VVP platform provides reproducible visual field sensitivity measurements for glaucoma patients and glaucoma suspects and represents a novel approach for glaucoma monitoring. These data suggest that VVP measurement repeatability is consistent with standard automated perimetry.

This is a 2020 ARVO Annual Meeting abstract.