June 2020
Volume 61, Issue 7
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ARVO Annual Meeting Abstract  |   June 2020
OCT Angiography vs Laser Speckle Contrast Imaging: Correlation between Static and Dynamic Measurements of Peripapillary Blood Flow in Glaucoma, Glaucoma Suspect, and Healthy Eyes
Author Affiliations & Notes
  • Alfred Vinnett
    Ophthalmology, University of Maryland School of Medicine, Baltimore, Maryland, United States
  • Samuel Asanad
    Ophthalmology, University of Maryland School of Medicine, Baltimore, Maryland, United States
  • Kyoung-A Cho
    Vasoptic Medical, Inc., Baltimore, Maryland, United States
  • Patricia Manalastas
    Heidelberg Engineering, Inc., Germany
  • Abhishek Rege
    Vasoptic Medical, Inc., Baltimore, Maryland, United States
  • Osamah Saeedi
    Ophthalmology, University of Maryland School of Medicine, Baltimore, Maryland, United States
  • Footnotes
    Commercial Relationships   Alfred Vinnett, None; Samuel Asanad, None; Kyoung-A Cho, Vasoptic Medical Inc. (I), Vasoptic Medical Inc. (E); Patricia Manalastas, Heidelberg Engineering, Inc. (E); Abhishek Rege, Vasoptic Medical Inc. (E), Vasoptic Medical Inc. (P), Vasoptic Medical Inc. (I); Osamah Saeedi, Heidelberg Engineering, Inc. (F), NIH/NEI, Grant Number k23ey025014 (F), Vasoptic Medical Inc. (F)
  • Footnotes
    Support  Maryland Industrial Partnerships (MIPS) award
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 617. doi:
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      Alfred Vinnett, Samuel Asanad, Kyoung-A Cho, Patricia Manalastas, Abhishek Rege, Osamah Saeedi; OCT Angiography vs Laser Speckle Contrast Imaging: Correlation between Static and Dynamic Measurements of Peripapillary Blood Flow in Glaucoma, Glaucoma Suspect, and Healthy Eyes. Invest. Ophthalmol. Vis. Sci. 2020;61(7):617.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCTA) and laser speckle contrast imaging (LSCI) are two technologies for non-invasively quantifying retinal blood flow, which is reportedly reduced in glaucoma. However, comparative studies on the static and dynamic measures of blood flow, as provided by these two imaging modalities, are limited. We investigated the relationship between OCTA and LSCI measurements of the peripapillary retinal vasculature in glaucoma, glaucoma suspect, and healthy eyes.

Methods : We prospectively enrolled 3 glaucoma, 3 glaucoma suspects, and 6 healthy subjects. For OCTA, the Heidelberg Spectralis OCT2 was used to measure peripapillary perfusion density (PD). For LSCI, the XyCAM Retinal Imager was used to measure systolic (peak), diastolic (trough), and mean blood flow velocity indices (BFVi – arbitrary units) in the vessels within the optic disc while masking the optic disc interstitium. Mann–Whitney U test was used to compare pairs of independent groups. Spearman correlation was used to evaluate the relationships between OCTA and LSCI measurements.

Results : OCTA PD correlated significantly and equally with systolic (r = 0.51; p < 0.04) and mean BFVi (r = 0.51; p < 0.04). OCTA PD did not significantly correlate with diastolic BFVi (r = 0.35; p = 0.14).

Conclusions : We provide a quantitative comparison between static measurements of peripapillary blood flow by OCTA and dynamic measurements by LSCI. Our results are comparable or better than previously reported associations between these two technologies (Kiyota et al. 2018). Notably, OCTA correlated more with LSCI during systole as compared to diastole. These findings suggest that the pulsatile behavior of blood flow in systole and diastole as measured by dynamic imaging modalities may be clinically useful for evaluating ocular disease such as glaucoma.

This is a 2020 ARVO Annual Meeting abstract.

 

Figure. Comparison between optical coherence tomography angiography (OCTA) and laser speckle contrast imaging (LSCI). OCTA depicts peripapillary perfusion density on a 12-sector clock hour grid centered on the optic nerve head (ONH) (A). LSCI illustrates blood flow velocity index of the ONH vessels (interstitium masked) acquired during diastole (B) and systole (C) with synchronized pulse oximetry (D).

Figure. Comparison between optical coherence tomography angiography (OCTA) and laser speckle contrast imaging (LSCI). OCTA depicts peripapillary perfusion density on a 12-sector clock hour grid centered on the optic nerve head (ONH) (A). LSCI illustrates blood flow velocity index of the ONH vessels (interstitium masked) acquired during diastole (B) and systole (C) with synchronized pulse oximetry (D).

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