July 2020
Volume 61, Issue 9
Free
ARVO Imaging in the Eye Conference Abstract  |   July 2020
Measurement of the Hypotenuse of the Vertical Optic Nerve Head Cup with SD-OCT as a Diagnostic Biomarker for Glaucoma.
Author Affiliations & Notes
  • Fernanda Mari Fagundes Fujihara
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
    Ophthalmology, Hospital Banco de Olhos de Porto Alegre, Porto Alegre, RS, Brazil
  • Paulo Augusto de Arruda Mello
    Federal University of Sao Paulo, Brazil
  • Rodrigo Leivas Lindenmeyer
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
  • Camila Zanella Benfica
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
  • Nedio Castoldi
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
  • Fernanda Miranda Mendes
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
    Ophthalmology, Federal University of Rio Grande do Sul, Brazil
  • Egidio Picetti
    Ophthalmology, Hospital Nossa Senhora da Conceicao, Brazil
  • Jaco Lavinsky
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
    Ophthalmology, Federal University of Rio Grande do Sul, Brazil
  • Daniel Lavinsky
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
    Ophthalmology, Federal University of Rio Grande do Sul, Brazil
  • Glauber Correa Gobbato
    Medical School, Lutheran University of Brazil, Brazil
  • Helena Messinger Pakter
    Ophthalmology, Federal University of Rio Grande do Sul, Brazil
    Ophthalmology, Hospital Nossa Senhora da Conceicao, Brazil
  • Fabio Lavinsky
    Ophthalmology, Hospital de Clinicas de Porto Alegre, Brazil
    Federal University of Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships   Fernanda Mari Fujihara, None; Paulo Augusto Mello, None; Rodrigo Lindenmeyer, None; Camila Benfica, None; Nedio Castoldi, None; Fernanda Mendes, None; Egidio Picetti, None; Jaco Lavinsky, None; Daniel Lavinsky, None; Glauber Gobbato, None; Helena Pakter, None; Fabio Lavinsky, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB00109. doi:
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      Fernanda Mari Fagundes Fujihara, Paulo Augusto de Arruda Mello, Rodrigo Leivas Lindenmeyer, Camila Zanella Benfica, Nedio Castoldi, Fernanda Miranda Mendes, Egidio Picetti, Jaco Lavinsky, Daniel Lavinsky, Glauber Correa Gobbato, Helena Messinger Pakter, Fabio Lavinsky; Measurement of the Hypotenuse of the Vertical Optic Nerve Head Cup with SD-OCT as a Diagnostic Biomarker for Glaucoma.. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB00109.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This study aims to evaluate the hypotenuse of the vertical optic nerve head cup (HVOC) and its association with structural and functional parameters in glaucomatous eyes and controls.

Methods : Subjects with glaucoma and controls underwent 24-2 perimetry and OCT. A vertical B-scan of the ONH with the largest cup extension was used for the measurements. The HVOC was calculated using the sides of a right triangle formed by the length and depth of the optic nerve cup. The length was measured as the distance between the innermost portion of the descending RNFL tissue at the Bruch’s membrane opening level. The depth was measured as the mean of the distances between the former line and the maximum and minimum depth of the superior, central and inferior portions of the anterior prelaminar tissue and the anterior limit of the lamina cribrosa (Figure 1). The circumpapillary retinal nerve fiber layer (cRNFL) and ganglion cell layer/inner plexiform layer (GCIPL) were analyzed using the average of the sectors from the ETDRS grid circles. Statistical analysis was performed using generalized estimating equations to allow for clustered observations. Age, gender, presence of glaucoma and disc area were accounted in the model. The area under the receiver operating characteristics curve (AUROC) for HVOC was also calculated.

Results : 109 eyes (67 subjects) were included, 95 in the glaucoma group and 14 in the control. The mean age was 66.13±12.38. The mean HVOC at the pre-laminar level (PL-HVOC) was 1298.80±291.99µm and 758.58±300.70µm for glaucoma and normal eyes, respectively, whereas the HVOC at the lamina cribrosa level (LC-HVOC) was 1341.15±290.22µm and 791.43±286.53µm, respectively. Both HVOC measurements were significantly associated with the cRNFL, GCIPL, mean deviation and visual field index, with a negative correlation (Table 1). Age and gender weren’t significant in any of the models. The AUROC for the PL-HVOC and LC-HVOC was 0.901 and 0.907, respectively (P<0.001).

Conclusions : The HVOC was significantly associated with structural and functional glaucoma parameters both at the pre-laminar and at the laminar levels. It differentiated well between normal and glaucomatous eyes. This parameter may constitute an additional ONH biomarker for the structural diagnosis and monitoring of glaucoma.

This is a 2020 Imaging in the Eye Conference abstract.

 

Measurement of the HVOC

Measurement of the HVOC

 

Association between HVOC and Visual Field, cRNFL and GCIPL.

Association between HVOC and Visual Field, cRNFL and GCIPL.

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