July 2020
Volume 61, Issue 9
Open Access
ARVO Imaging in the Eye Conference Abstract  |   July 2020
Visible-Light OCT Captures In-vivo Changes in Retinal Oximetry in Ischemic Retinal Diseases
Author Affiliations & Notes
  • Jonathan Kfir
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Zeinab Ghassabi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Mengfei Wu
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Division of Biostatistics, Departments of Population Health and Environmental Medicine, NYU School of medicine, New York, United States
  • Ian Rubinoff
    Department of Biomedical engineering, Northwestern University, Evanston, Illinois, United States
  • Roman V. Kuranov
    Department of Biomedical engineering, Northwestern University, Evanston, Illinois, United States
    Opticent, Evanston, Illinois, United States
  • Yuanbo Wang
    Opticent, Evanston, Illinois, United States
  • benjamin Davis
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Behnam Tayebi
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    NYU Langone Health, Neuroscience Institute, New York, New York, United States
  • Joel Schuman
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering, NYU Tandon School of Engineering , Brooklyn, New York, United States
  • Hao Zhang
    Department of Biomedical engineering, Northwestern University, Evanston, Illinois, United States
    Opticent, Evanston, Illinois, United States
  • Hiroshi Ishikawa
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Gadi Wollstein
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Footnotes
    Commercial Relationships   Jonathan Kfir, None; Zeinab Ghassabi, None; Mengfei Wu, None; Ian Rubinoff, None; Roman V. Kuranov, Opticent Inc (E); Yuanbo Wang, Opticent Inc (E); benjamin Davis, None; Behnam Tayebi, None; Joel Schuman, zeiss (P); Hao Zhang, Opticent (I); Hiroshi Ishikawa, None; Gadi Wollstein, None
  • Footnotes
    Support  NIH: R01-EY013178 and an unrestricted grant by the Research to Prevent Blindness
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB00111. doi:
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      Jonathan Kfir, Zeinab Ghassabi, Mengfei Wu, Ian Rubinoff, Roman V. Kuranov, Yuanbo Wang, benjamin Davis, Behnam Tayebi, Joel Schuman, Hao Zhang, Hiroshi Ishikawa, Gadi Wollstein; Visible-Light OCT Captures In-vivo Changes in Retinal Oximetry in Ischemic Retinal Diseases. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB00111.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Visible-light (vis-) OCT utilizes the hemoglobin light absorption properties within the visible spectral range to enable precise, in-vivo, non-invasive measurement of retinal oxygen saturation (sO2). This study tested the hypothesis that in ischemic retinal areas with neovascularization, the vein sO2 is relatively lower compared to unaffected areas, to compensate for the impaired flow in the obstructed vessel.

Methods : The sO2 was measured with our vis-OCT (8192 x 16 samplings in 1x1mm2, horizontal sampling interval = 0.12 µm) prototype, in two matched artery and retinal veins, in the affected and unaffected areas, of 3 subjects with retinal vessel occlusion. Subject 1 - a 72 years old woman, 10 years after cilio-retinal branch occlusion; Subject 2 - a 38 years old woman, 5 months after central retinal vein occlusion (CRVO); and subject 3 - a 61 years old woman, 1.5 years after inferior branch retinal vein occlusion (BRVO). In order to get accurate sO2 estimation, wavelength-dependent OCT amplitudes from identical depth locations across multiple A-lines were averaged. The averaged signal, based on Beer-Lambert’s law, was then fitted to hemoglobin absorption values.

Results : The retinal vein sO2 in ischemic areas was consistently lower compared to veins in unaffected areas, with an average decrease of 6.3% (Table). The biggest difference was detected in the subject with BRVO while the smallest in the cilio-retinal branch occlusion. No difference was noted in retinal arteries sO2.

Conclusions : The relative lower oxygen saturation in retinal veins located in ischemic areas with neovascularization might be due to an increase in oxygen consumption per unit volume of blood. Further studies are warranted to examine the diagnostic and monitoring use of oximetry information acquired with vis-OCT.

This is a 2020 Imaging in the Eye Conference abstract.

 

Table. sO2 values in Ischemic and unaffected area

Table. sO2 values in Ischemic and unaffected area

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