July 2020
Volume 61, Issue 9
Free
ARVO Imaging in the Eye Conference Abstract  |   July 2020
Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.
Author Affiliations & Notes
  • Luísa S. M. Mendonca
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
    Department of Ophthalmology, Federal University of Sao Paulo, Brazil
  • Siyu Chen
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, , Massachusetts Institute of Technology, Massachusetts, United States
  • Omar Abu-Qamar
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
  • Eric Moult
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, , Massachusetts Institute of Technology, Massachusetts, United States
  • Michelle C. Liang
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
  • Andre Witkin
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
  • Caroline Baumal
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
  • Jay Duker
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
  • James Fujimoto
    Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, , Massachusetts Institute of Technology, Massachusetts, United States
  • Nadia Waheed
    New England Eye Center, Tufts University, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Luísa Mendonca, None; Siyu Chen, None; Omar Abu-Qamar, None; Eric Moult, None; Michelle Liang, None; Andre Witkin, None; Caroline Baumal, Carl Zeiss Meditec (R), Genentech (C), Genentech (R), Novartis (R); Jay Duker, Akebia (C), Allergan (C), Aura Biosciences (C), Bausch Lomb (C), Beyeonics (C), Carl Zeiss Meditec, Optovue (F), Eyepoint Pharma (S), Graybug vision (C), Helio Vision (C), Hemera Biosciences (I), Kala pharma (C), Novartis (C), Roche/Genentech (C), Sesen Bio (S), Sigilion (C); James Fujimoto, Carl Zeiss Meditec (P), Optovue (P), Optovue (I), Optovue (C), Topcon (F); Nadia Waheed, Gyroscope (S), Nidek (R), Topcon, Apellis, Astellas, Boehringer Ingelheim, Novartis, Carl Zeiss Meditec (S), Topcon, Roche/Genentech, Regeneron, Apellis, Astellas, Boehringer Ingelheim, Novartis (C)
  • Footnotes
    Support  This work was supported with scholarship provided by Capes Foundation – “Coordenação de Aperfeiçoamento de Pessoal de Nível Superior” – Brazil, in the scope of Capes-PrInt program, process no 88887.369769/2019-00
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB00136. doi:
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      Luísa S. M. Mendonca, Siyu Chen, Omar Abu-Qamar, Eric Moult, Michelle C. Liang, Andre Witkin, Caroline Baumal, Jay Duker, James Fujimoto, Nadia Waheed; Ultrahigh Resolution Spectral Domain Optical Coherence Tomography for the Assessment of Micro-Structural Changes in Central Serous Chorioretinopathy: A Pilot Study.. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB00136.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : In central serous chorioretinopathy (CSCR), choroidal hyperpermeability associated with retinal pigment epithelium (RPE) impairment causes a leakage of fluid from the choroid into the subretinal space, with potential damage to the photoreceptors. We hypothesize that ultrahigh-resolution spectral domain optical coherence tomography (UHR SD-OCT) will enable more detailed assessment of structural changes in this condition.

Methods : Patients in all stages of CSCR (acute, chronic and post-resolution) were imaged using an UHR SD-OCT prototype, with an 850 nm center wavelength and an axial resolution of ~2.7 µm in tissue at a 128kHz A-scan rate. Volumetric cube scans and high-density (HD) scans were acquired covering 6×6 mm2 and 9×6 mm2 fields of view, respectively. Comparative images were also obtained using a commercial SD-OCT device, with an axial resolution of 5 µm in tissue at a 68 kHz A-scan rate. For post-resolution CSCR cases, a qualitative assessment of the integrity of the outer retina bands (interdigitation zones, inner segment (IS), outer segment (OS) and IS/OS junction / ellipsoid zone) and BM-RPE complex was performed. For acute and chronic cases, the integrity of RPE-BM complex at the leakage site was assessed qualitatively.

Results : To date, 7 eyes of 7 patients were imaged. Results show that UHR SD-OCT images allowed superior visualization and resolution of outer retina bands and its defects compared to the commercial SD-OCT (Figure 1). Further data collection and analysis of the RPE-BM complex in relation to the leakage site are ongoing.

Conclusions : UHR SD-OCT allows a more detailed assessment of structural changes in CSCR, in its acute, chronic and post-resolution phases. The ability to detect subtle structural changes in the BM-RPE complex of patients with acute CSCR may improve the understanding of disease pathophysiology.

This is a 2020 Imaging in the Eye Conference abstract.

 

Examples of three CSCR cases imaged concurrently on the UHR SD-OCT system (A, C & E) and a commercial SD-OCT system (B, D & F). All images are of unaveraged B-scans, acquired on a volumetric scan protocol. A & B: B-scans of an acute CSCR case. C & D: B-scans of a post-resolution case. E & F: B-scans of a chronic CSCR case.

Examples of three CSCR cases imaged concurrently on the UHR SD-OCT system (A, C & E) and a commercial SD-OCT system (B, D & F). All images are of unaveraged B-scans, acquired on a volumetric scan protocol. A & B: B-scans of an acute CSCR case. C & D: B-scans of a post-resolution case. E & F: B-scans of a chronic CSCR case.

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