July 2020
Volume 61, Issue 9
Free
ARVO Imaging in the Eye Conference Abstract  |   July 2020
Retinal vascular indices in Adult-onset foveomacular vitelliform dystrophy, Age-related macular degeneration and healthy eyes: An OCT-angiography study
Author Affiliations & Notes
  • Iris Deitch Harel
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Raviv Katz
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Ying Cui
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
    Ophthalmology, Guangdong Eye Institute, China
  • Archana Nigalye
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Ying Zhu
    Xiangya Hospital, China
  • Inês Laíns
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Jay Wang
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Yifan Lu
    Harvard Medical School, Massachusetts, United States
    Harvard Retinal Imaging Lab, Boston, Massachusetts, United States
  • Rebecca Zeng
    Boston University Medical School, Boston, Massachusetts, United States
  • Ivana K Kim
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
  • Demetrios Vavvas
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
  • Joan Miller
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
  • Deeba Husain
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
  • John Miller
    Retina service, Massachusetts Eye and Ear , Brookline, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Iris Deitch Harel, None; Raviv Katz, None; Ying Cui, None; Archana Nigalye, None; Ying Zhu, None; Inês Laíns, None; Jay Wang, None; Yifan Lu, None; Rebecca Zeng, None; Ivana Kim, None; Demetrios Vavvas, None; Joan Miller, None; Deeba Husain, None; John Miller, Zeiss (C)
  • Footnotes
    Support  MEE PS# 2100550
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB0040. doi:
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      Iris Deitch Harel, Raviv Katz, Ying Cui, Archana Nigalye, Ying Zhu, Inês Laíns, Jay Wang, Yifan Lu, Rebecca Zeng, Ivana K Kim, Demetrios Vavvas, Joan Miller, Deeba Husain, John Miller; Retinal vascular indices in Adult-onset foveomacular vitelliform dystrophy, Age-related macular degeneration and healthy eyes: An OCT-angiography study. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB0040.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the retinal vascular indices among patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) and patients with intermediate age-related macular degeneration (iAMD) and age-matched healthy controls, using widefield swept source optical coherence tomography angiography (WSS-OCTA).

Methods : Retrospective, cross sectional study. Patients with AOFVD or with iAMD (based on clinical exam) and without other retinal or systemic diseases and healthy controls were invited to participate. Included participants underwent Swept Source-OCT Angiography (OCT-A) with Plex Elite 9000 (Carl Zeiss Meditec Inc., Dublin, CA, USA), 12 mm x12 mm scan, centered on the macula; and spectral domain OCT (Heidelberg, Spectralis). The 12 mm x 12 mm OCT-A volume of the superficial capillary plexus (SCP) and the deep capillary plexus (DCP) vessels were then exported, and projection artifacts were removed with the commercially available software. Vessel area density (VAD), vessel skeletonized density (VSD), vessel diameter Index (VDI), vessel perimeter index (VPI) and vessel complexity Index (VCI) were calculated using ImageJ software (Bethesda, MD). Vessel indices of the SCP and DCP were compared between patients with AOFVD to patients with iAMD and controls. Multilevel mixed models were used to account for the inclusion of two eyes of some patients.

Results : We included 22 eyes with AOFVD (11 patients), 86 eyes with iAMD (55 patients) and 62 healthy age-matched control eyes (33 patients). Compared to iAMD patients, AOFVD patients had a significantly higher VCI of the SCP (b=197921, p=0.005). However, no differences were found for VAD, VSD, VDI, and VPI of the SCP. In the DCP, there were significant reductions of VAD (b=-4.19, p=0), VSD (b=-1.36, p=0), VDI (b=-0.034, p=0.04), and VPI (b=-1.85, p=0) in AOFVD compared to iAMD. Compared to control, the DCP of AOFVD was significantly associated with only VSD (p=0.049) reductions, with no other significant correlations identified.

Conclusions : Patients with AOFVD have a significantly higher VCI in the SCP compared to patients with iAMD, as well as lower vascular densities in the DCP. OCT angiography might be useful in differentiation between these entities.

This is a 2020 Imaging in the Eye Conference abstract.

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