July 2020
Volume 61, Issue 9
Free
ARVO Imaging in the Eye Conference Abstract  |   July 2020
En face attenuation-and-flow imaging by swept-source OCT
Author Affiliations & Notes
  • Shuichi Makita
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Japan
  • Tatsuo Yamaguchi
    Topcon Corporation, Itabashi, Tokyo, Japan
  • Toshihiro Mino
    Topcon Corporation, Itabashi, Tokyo, Japan
  • Shinnosuke Azuma
    Topcon Corporation, Itabashi, Tokyo, Japan
  • Masahiro Miura
    Department of Ophthalmology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Japan
  • Yoshiaki Yasuno
    Computational Optics Group, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Computational Optics and Ophthalmology Group, Japan
  • Footnotes
    Commercial Relationships   Shuichi Makita, Kao Corporation (F), Nikon (F), Tomey Corporation (F), Tomey Corporation (P), Topcon Corporation (F), Yokogawa Electric Corporation (F); Tatsuo Yamaguchi, TOPCON (E); Toshihiro Mino, TOPCON (E); Shinnosuke Azuma, TOPCON (E); Masahiro Miura, Novartis (F), Santen (F), Senju (R), Senju (F); Yoshiaki Yasuno, Kao (F), Nikon (F), Tomey Corp. (F), Tomey Corp. (P), TOPCON (F), Yokogawa (F)
  • Footnotes
    Support  JSPS grant 18K09460 and 18H01893, JST grant JPMJMI18G8
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB0066. doi:
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      Shuichi Makita, Tatsuo Yamaguchi, Toshihiro Mino, Shinnosuke Azuma, Masahiro Miura, Yoshiaki Yasuno; En face attenuation-and-flow imaging by swept-source OCT. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB0066.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography angiography (OCT-A) is an en face imaging modality that highlights the vascular abnormality. On the other hand, tissue light attenuation (TLA) can be a direct indicator or tissue scattering abnormalities that would be sensitive to the thickening of the retinal pigment epithelium (RPE), hyperreflective foci, and choroidal neovascularization (CNV). While OCT-A is an en face modality, TLA should have been interpreted in a depth-resolved manner. Hence, these two had to be used separately. This presentation demonstrates a new en-face-image-formation method that fuses OCT-A and TLA signals and gives an en face image being sensitive to the vasculature and tissue scattering abnormalities.

Methods : The custom-made 1.0-µm swept-source OCT, similar to a commercially available SS-OCT, was used. Depth-resolved cumulative TLA (cTLA), which is the total amount of light attenuation occurred from the surface to the particular depth of the tissue, is computed from the OCT. The cTLA and 3D OCT-A volumes are fused into a pseudo-color tomographic volume. The cTLA defines the pixel color, and the OCT-A defines the pixel brightness. An en face pseudo-color image (attenuation-and-flow image; AAF) is obtained by projecting along with depth. In this en face image, the vessels are appeared with different colors according to the total amount of light attenuating materials above the vessel as blue-red-yellow (more to less attenuating material).

Results : Figure 1 shows en face images of a choroidal neovascularization (CNV) subject. The en face OCT (Fig. 1 A) and OCT-A (entire depth, Fig. 1 B) visualize the distributions of attenuation difference and vasculature. The en face AAF image (Fig. 1 C) visualizes the light attenuation property of the tissue, vasculature, and, the relative depth position of them. At the CNV location, some parts of the vessels appear in red. It suggests that highly attenuating materials do not exist above the vessel. And, these red-color vessels collocate with the hyper-fluorescence of fluorescein angiography (Fig 1D).

Conclusions : The en face AAF image was found to visualize the tissue attenuation property and vessel abnormality successfully. Since this imaging method does not require special hardware, it can be quickly applied to the current daily diagnostic routine.

This is a 2020 Imaging in the Eye Conference abstract.

 

Fig. 1 En face imaging results of a subject with CNV. (A) OCT projection, (B) OCT-A of entire depth, (C) AAF images, (D) fluorescein angiography.

Fig. 1 En face imaging results of a subject with CNV. (A) OCT projection, (B) OCT-A of entire depth, (C) AAF images, (D) fluorescein angiography.

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