July 2020
Volume 61, Issue 9
Open Access
ARVO Imaging in the Eye Conference Abstract  |   July 2020
Relationship Between Ocular Structure and Visual Sensitivity Using Virtual-Reality Perimetry
Author Affiliations & Notes
  • Jason Adam Greenfield
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Michael Deiner
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Anwell Nguyen
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Gadi Wollstein
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Bertil Damato
    Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Benjamin Backus
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Mengfei Wu
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
  • Joel Schuman
    Department of Ophthalmology, NYU Langone Health, New York, New York, United States
    Department of Biomedical Engineering, NYU Tandon School of Engineering, New York, New York, United States
  • Yvonne Ou
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Jason Greenfield, None; Michael Deiner, None; Anwell Nguyen, None; Gadi Wollstein, None; Bertil Damato, None; Benjamin Backus, Vivid Vision, Inc (E); Mengfei Wu, None; Joel Schuman, Zeiss (P); Yvonne Ou, None
  • Footnotes
    Support  NIH: R01-EY013178
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB0076. doi:
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    • Get Citation

      Jason Adam Greenfield, Michael Deiner, Anwell Nguyen, Gadi Wollstein, Bertil Damato, Benjamin Backus, Mengfei Wu, Joel Schuman, Yvonne Ou; Relationship Between Ocular Structure and Visual Sensitivity Using Virtual-Reality Perimetry. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB0076.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Vivid Vision Perimetry (VVP, Vivid Vision, San Francisco, CA) is a novel method for performing in-office and home-based virtual-reality visual field assessment. The purpose of this study was to examine the relationship between visual sensitivity measured with VVP and retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness measurements using spectral domain optical coherence tomography (SD-OCT).

Methods : Subjects with clinical diagnosis of glaucoma or glaucoma suspect were enrolled. All subjects underwent VVP and SD-OCT imaging (Optovue, Fremont, CA) in both eyes. Mean sensitivity (dB) measurements were obtained from two VVP examinations from 54 test points in a 24-2 pattern and average RNFL and GCC thickness (mm) were measured. The association between VVP and SD-OCT parameters was determined using mixed effects models, adjusting for the intra-subject eye correlation.

Results : Fourteen eyes of 7 subjects with glaucoma (mean age 65.6 +/- 10.4 years, 29% female) and 10 eyes of 5 glaucoma suspects (mean age 57.8 years, 40% female) were enrolled. Compared to glaucoma suspects, subjects with glaucoma had worse average mean sensitivity, average RNFL, and average GCC (Table 1). Mean visual sensitivity measurements were significantly associated with average RNFL thickness (R=0.66, p=0.01) and GCC thickness (R=0.63, p=0.02).

Conclusions : VVP measurements of the visual field are associated with the structural measurements of both RNFL and GCC thickness. The correspondence identified is comparable to the known structure-function relationship demonstrated by standard automated perimetry and OCT.

This is a 2020 Imaging in the Eye Conference abstract.

 

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