July 2020
Volume 61, Issue 9
Free
ARVO Imaging in the Eye Conference Abstract  |   July 2020
Artifact rates for 2D retinal nerve fiber layer thickness versus 3D neuroretinal rim thickness using spectral domain optical coherence tomography
Author Affiliations & Notes
  • Elli Park
    Boston University School of Medicine, Boston, Massachusetts, United States
  • Edem Tsikata
    Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Jenny Jyoung Lee
    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States
  • Geulah Ben-David
    Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
    Department of Ophthalmology, Emek Medical Center, Afula, Israel
  • Stephanie Choi
    Harvard Medical School, Boston, Massachusetts, United States
  • Janice Kim
    Harvard Medical School, Boston, Massachusetts, United States
  • Yingna Liu
    Harvard Medical School, Boston, Massachusetts, United States
    Department of Ophthalmology, University of California, San Francisco, California, United States
  • Clara Men
    Harvard Medical School, Boston, Massachusetts, United States
    Shiley Eye Institute, University of California, San Diego, California, United States
  • Georgia Papadogeorgou
    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States
    Department of Statistical Science, Duke University, Durham, North Carolina, United States
  • Kitiya Ratanawongphaibul
    Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
    Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
  • Eric Shieh
    Harvard Medical School, Boston, Massachusetts, United States
    Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, United States
  • Alice Verticchio Vercellin
    Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States
    University of Pavia, Pavia, Italy
  • Johannes de Boer
    LaserLab Amsterdam, Department of Physics and Astronomy, Vrije Universiteit, Netherlands
    Department of Ophthalmology, Amsterdam University Medical Center, Netherlands
  • Teresa Chen
    Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States
  • Footnotes
    Commercial Relationships   Elli Park, None; Edem Tsikata, None; Jenny Lee, None; Geulah Ben-David, None; Stephanie Choi, None; Janice Kim, None; Yingna Liu, None; Clara Men, None; Georgia Papadogeorgou, None; Kitiya Ratanawongphaibul, None; Eric Shieh, None; Alice Verticchio Vercellin, None; Johannes de Boer, None; Teresa Chen, None
  • Footnotes
    Support  National Institutes of Health UL1 RR 025758, Massachusetts Lions Eye Research Fund (New Bedford, Massachusetts), American Glaucoma Society Mid-Career Award (San Francisco, California), Fidelity Charitable Fund (Harvard University), and Department of Defense Small Business Innovation Research DHP15-016
Investigative Ophthalmology & Visual Science July 2020, Vol.61, PB008. doi:
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      Elli Park, Edem Tsikata, Jenny Jyoung Lee, Geulah Ben-David, Stephanie Choi, Janice Kim, Yingna Liu, Clara Men, Georgia Papadogeorgou, Kitiya Ratanawongphaibul, Eric Shieh, Alice Verticchio Vercellin, Johannes de Boer, Teresa Chen; Artifact rates for 2D retinal nerve fiber layer thickness versus 3D neuroretinal rim thickness using spectral domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2020;61(9):PB008.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The minimum distance band (MDB) is a 3D neuroretinal rim measurement derived from high-density spectral domain optical coherence tomography (OCT) volume scans of the optic nerve using customized research software. Although the MDB has equal or better diagnostic capability for glaucoma compared to the traditional 2D peripapillary RNFL (pRNFL) thickness parameter, the artifact rate of this newer 3D parameter is still unknown. We performed a cross-sectional, observational clinical study to compare the rate of clinically significant artifacts per eye for 2D pRNFL thickness versus 3D MDB thickness.

Methods : Only one eye per patient was used for analysis in 120 glaucoma patients and 114 normal patients. A total of 15 artifact types were recorded for 2D and 3D OCT scans, and artifact rates were calculated per B-scan and per eye. In 3D volume scans, artifacts were recorded for only the B-scans which intersected the optic nerve and which were used for final neuroretinal rim calculations. Global MDB thickness values were calculated twice, once before and then once after manual deletion of B-scans with artifacts and subsequent automated interpolation. A clinically significant artifact is defined as one that requires a repeat scan in order to obtain an accurate measurement. Pre- and post-interpolation measurements were considered equivalent if they differed by less than normal inter-test variability.

Results : Among glaucomatous eyes, artifacts were present in 71.7% of 2D pRNFL thickness scans (86 of 120) and 20.9% of B-scans (1423 of 6820) in 3D MDB volume scans. Mean global MDB thickness was similar before and after interpolation in both the glaucoma group (169.3 ± 50.7 μm versus 176.1 ± 50.7 μm, respectively, p-value=0.30) and the normal group (303.8 ± 44.5 μm versus 309.4 ± 43.0 μm, respectively, p-value=0.33). Three-dimensional scans were less likely to have clinically significant artifacts, with 15.8% (19 of 120) of glaucomatous eyes and 13.2% (15 of 114) of normal eyes with artifacts compared to 2D pRNFL scans with 71.7% (86 of 120) of glaucomatous eyes and 38.6% (44 of 114) of normal eyes with artifacts (p-value<0.0001 for both groups).

Conclusions : Compared to the traditional 2D pRNFL thickness scans, 3D optic nerve volume scans less frequently require manual correction and repeat scanning to obtain accurate measurements.

This is a 2020 Imaging in the Eye Conference abstract.

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