Rapid Myopic Progression in Childhood Is Associated With Teenage High Myopia

Abstract

Purpose: The purpose of this study was to evaluate the association of childhood progression of spherical equivalent (SE) with high myopia (HM) in teenagers in the Singapore Cohort of Risk factors for Myopia (SCORM).

Methods: We included 928 SCORM children followed over a mean follow-up of 6.9 ± 1.0 years from baseline (6–11 years old) until their teenage years (12–19 years old). Cycloplegic autorefraction and axial length (AL) measurements were performed yearly. The outcomes in teenagers were HM (SE ≤ −5 diopter [D)], AL ≥ 25 mm, SE and AL. Three-year SE and AL progression in childhood and baseline SE and AL with outcomes were evaluated using multivariable logistic or linear regression models, with predictive performance of risk factors assessed using the area under the curve (AUC).

Results: At the last visit, 9.8% of teenagers developed HM and 22.7% developed AL ≥ 25 mm. In multivariate regression analyses, every −0.3 D/year increase in 3-year SE progression and every 0.2 mm/year increase in 3-year AL progression were associated with a −1.14 D greater teenage SE and 0.52 mm greater teenage AL (P values < 0.001). The AUC (95% confidence interval [CI]) of a combination of 3-year SE progression and baseline SE for teenage HM was 0.97 (95% CI = 0.95 – 0.98). The AUC of 3-year AL progression and baseline AL for teenage AL ≥ 25 mm was 0.91 (95% CI = 0.89 – 0.94).

Conclusions: Three-year myopia progression in childhood combined with baseline SE or AL were good predictors of teenage HM. Clinicians may use this combination of factors to guide timing of interventions, potentially reducing the risk of HM later in life.

The increase in myopia prevalence in the last few decades impose a significant public health concern with high economic costs for the society.^1–5 High myopia (HM, spherical equivalent [SE] ≤ −5 diopter [D] or −6 D) in young adults is reaching epidemic proportions in East and Southeast Asia with prevalence rates reported to range between 8% and 21.6% from childhood to young adulthood.^6–9 Individuals with HM have increased susceptibility to visual impairment (VI) and blindness due to macular and retinal complications in later adulthood.^10–15 Myopic macular degeneration (MMD) where significant retinal or optic nerve lesions are present is a common cause of irreversible VI in Asian populations.^16,17 

Previous longitudinal studies, from childhood to young adulthood, have identified childhood risk factors, including younger age of onset of myopia^18–20 and higher myopic baseline SE,²¹ to be predictive of HM later in life. The Singapore Cohort of Risk factors for Myopia (SCORM) had shown that earlier age of onset of myopia was a risk factor for the development of HM in 11-year-olds.¹⁸ Similar results were found in a Denmark study, where children (9 to 12 years at baseline) with younger age of myopia onset were more likely to develop HM after 8 years of follow-up (17–20 years old).¹⁹ In a population-based prospective cohort study of twins in Guangzhou, China, with a 12-year annual follow-up, the risk of HM was high in children with myopia onset during the early school ages (mean ± standard deviation [SD] age at myopia onset, 11.7 ± 2.0 years).²⁰ In the Correction of Myopia Evaluation Trial (COMET), including children aged 6 to 11 years at baseline, younger age and higher myopic SE at baseline were identified as significant risk factors for developing HM after 7 years of follow-up.²¹ 

Better understanding of the impact of early childhood myopia progression on the development of HM later in life (with the associated risk of VI) can potentially guide clinical management for timely interventions. However, few, if any, prospective longitudinal studies have examined the specific role of early childhood myopia progression as a risk factor for teenage HM. In the current study, we aimed to evaluate the association of short- and long-term SE progression in childhood with teenage HM using data from the longitudinal SCORM cohort. 

Methods

Study Population

SCORM is a prospective cohort whereby children from grades 1 to 3 were recruited from three Singapore schools (n = 1979), and the methodology has been described previously.^22–24 At baseline, children were excluded if they had serious medical conditions, such as leukemia or heart disorders, or syndrome-associated with myopia, or any eye disorders, such as congenital cataract.^25–27 Data for this study was derived from 1051 children who attended a minimum of 3 visits, including the baseline (1999–2001, aged 6–11 years) and the last follow-up visit (2007, teenagers aged 12 to 19 years, consistent with the World Health Organization's definition of adolescence²⁸). Of the 1051 children, we excluded those with HM (n = 27) and AL ≥ 25 mm (n = 47) at baseline. We further excluded 96 children that developed HM and 120 that developed AL ≥ 25 mm within the initial 3-year time frame. For the final analysis, 928 children with SE data and 859 children with AL data were included. Seven annual follow-up visits (mean ± SD = 6.9 ± 1.0 follow-up years, range = 6 to 8) were conducted in the schools and all children examined at the last follow-up were included in this study (Fig. 1). The study was conducted in accordance with the tenets of the Declaration of Helsinki and was approved by the Ethics Committee at the Singapore Eye Research Institute and the Centralized Institutional Review Boards of the Singapore Health Services (2016/2215). Written informed consent was obtained from the parents after the nature of the study was explained. 

Figure 1.

 

Follow-up status of eligible children for teenage years (12–19 years old) in SCORM.

Eye Measurements

Cycloplegic refraction was performed yearly. After the instillation of one drop of 0.5% proparacaine, cycloplegia was achieved with 3 drops of 1% cyclopentolate instilled at 5-minute intervals. After an interval of at least 30 minutes after the last eye drop, cycloplegic autorefraction was performed with a table-mounted autorefractor (model RK5; Canon, Japan). Five measurements were performed per eye (all readings <0.25 D apart) and total mean was used for analysis. AL measurements were obtained after instillation of 1 drop of 0.5% proparacaine. Contact ultrasound biometry was performed (Echoscan model US-800, probe frequency 10 mHz; Nidek Co., Ltd., Tokyo Japan). The average of six measurements was taken and accepted only if the SD of these readings was less than 0.12 mm. SE for each eye was calculated as sphere power plus half cylinder power. 

Assessment of Covariates

Height (cm) was measured with students standing and without shoes.²⁹ Questionnaires in English, Chinese, and Malay were administered to parents by a trained interviewer at the baseline visit. The questionnaires were administered to obtain demographic data, including the child's race, books read per week, and time spent outdoors (hours per week [h/wk]), as well as parental risk factors, such as mother's education level and number of parents with myopia.²³ Parents were considered myopic if they were wearing corrective lenses to see at distance. Time spent outdoors in teenage years was recorded separately for school weekdays and school weekends using an adapted version of the Sydney Myopia Study questionnaire and was defined as the sum of outdoor leisure and outdoor sporting activities.³⁰ 

Predictors of Teenage HM and AL ≥ 25 mm

Myopia was defined as an SE ≤ −0.5 D and HM as an SE ≤ −5 D. The outcomes of interest were teenage HM and AL ≥ 25 mm (top tertile cut point), teenage SE and AL at the last follow-up. Baseline SE (D) and AL (mm), age of myopia onset (y, years), 3 and 1-year mean SE progression (D/y), and 3 and 1-year mean AL progression (mm/y) were evaluated as predictive factors. We measured SE progression over the initial period of 3 years in children without myopia (SE > −0.5 D) and in children with mild to moderate myopia (SE ≤ −0.5 D to >−5 D) at baseline. Three-year mean SE and AL progression, defined as annual progression over a period of 3 years, were calculated as (SE at visit 4-SE at baseline)/3 and (AL at visit 4-AL at baseline)/3. One-year mean SE and AL progression, defined as progression over a period of 1 year, were calculated as (SE at visit 2-SE at baseline) and (AL at visit 2-AL at baseline). 

At baseline, age of onset of myopia was determined as the age at which corrective lenses were first prescribed to correct myopia.¹⁸ For children who developed myopia after the baseline visit, the age of onset of myopia was determined via annual eye examinations from the subsequent follow-up visits. 

Statistical Methods

Statistical analyses were performed on 928 children with available SE data and 859 children with available AL data. The more myopic eye (worse eye) of each subject at the last follow-up was chosen for analysis. Predictive factors, including initial 3 and 1-year SE or AL progression, SE, or AL at baseline, were analyzed as continuous variables (per SD increase). We examined the association of predictive factors with teenage HM and AL ≥ 25 mm using multiple logistic regression models and teenage SE and AL using multiple linear regression models, adjusting for confounders, such as age at baseline, height (only for AL), gender, race, mother's education, parental myopia, outdoor time, books read per week, and length of follow-up, with manual backward stepwise approaches. We performed two distinct analyses (1) in children with SE measures at the last follow-up (n = 928) and (2) in children with AL measures at the last follow-up (n = 859). For analysis in children with myopia at the last follow-up, we additionally evaluated age of onset of myopia. 

Receiver operating characteristics (ROCs) and areas under the curve (AUC) curves associated with logistic regression models were used to assess their operating characteristics for HM and AL ≥ 25 mm. Risk factors were progressively added comparing the discriminative ability using AUC to obtain the best clinical model. To correct the optimism bias, we performed a 10-fold cross validation for the AUC by averaging it across each fold and bootstrapping the cross-validated AUC to obtain its confidence intervals (CIs). We have also computed the estimated probability (or risk) of HM using the formula:  

\begin{equation*}\Pr \left( {HM|{x_1},{x_2}} \right) = \frac{{\exp \left\{ {{\beta _0} + {\beta _1}{x_1} + {\beta _2}{x_2}} \right\}}}{{1 + \exp \left\{ {{\beta _0} + {\beta _1}{x_1} + {\beta _2}{x_2}} \right\}}}\end{equation*}

where β₀ is the intercept term, and β₁ and β₂ are the log-odds of the two risk factors (i.e., x₁ and x₂). We plotted three estimated risks of HM as a function of one of the risk factors by specifying the other risk factor to take the value of its 25th, 50th, or 75th percentile. 

Any P ≤ 0.05 was considered statistically significant. All statistical analyses were carried out with SPSS (IBM, Armonk, NY, USA, version 26) and Stata (Stata Statistical Software, release 11; StataCorp LP, College Station, TX, USA). 

Results

A comparison of children included in this study (n = 928) with those who were excluded (n = 1051) showed no significant difference in terms of gender. Children who were included were younger at baseline, had shorter baseline AL, less myopic baseline SE, lower proportion of Chinese race, and non-myopic parents, and had higher proportion mothers with lower education level (all P < 0.05; data not shown). 

The characteristics of the study subjects are shown in Table 1. Of the 928 children with SE measures at the last follow-up, 9.8% (n = 91) developed HM, whereas 73.1% (n = 678) had myopia. Of the 859 children with AL measures, 22.7% (n = 195) of the children developed teenage AL ≥ 25 mm. Of those with both measures (n = 823), 4.4% (n = 36) developed both HM and teenage AL ≥ 25 mm. During the study follow-up, of the non-myopes at baseline (n = 680), 61.2% (n = 416) developed mild to moderate myopia, and 2.4% (n = 16) developed teenage HM; of the mild to moderate myopes at baseline (n = 248) 30.2% (n = 75) developed teenage HM. 

Table 1.

 

Demographics and Characteristics of Children Included in the Study

 

Among all children, the mean SE (± SD) of the more myopic eye was −2.03 ± 2.04 D at the last follow-up visit, whereas the mean AL was 24.38 ± 1.05 mm at the last follow-up visit. Mean SE progressed by −0.48 ± 0.43 D/y in the first year of the study and by −0.43 ± 0.33 D/y in the first 3 years of the study (from 7.8 ± 0.8 years old at baseline to 10.8 ± 0.8 years old at visit 4). Figure 2 shows that the teenage SE was highly correlated with the 3-year SE progression (r = 0.80) and SE at baseline (r = 0.73). The correlation between teenage SE and 1-year SE progression was lower (r = 0.66; data not shown). 

Figure 2.

 

Panel of scatter plots of teenage SE against SE at baseline and 3-year SE progression in SCORM. Three-year SE progression (D/y) was calculated as ((SE at visit 4 – SE at baseline)/3).

Of the 678 children with myopia at the last follow-up, 86.6% had mild to moderate myopia. The mean age of myopia onset was 9.4 ± 2.2 years with 41.1% developing myopia at or after the age of 10 years. Of the 91 children with HM, the mean age of myopia onset was 7.5 ± 1.1 years and mean age of HM onset was 13.3 ± 1.5 years. On average, children with myopia had 5.2 ± 2.3 years of myopic life (myopia duration in years) at the last follow-up and SE progressed by −0.59 ± 0.42 D/y in the first year of the study and by −0.55 ± 0.30 D/y in the first 3 years of the study. Higher duration of myopic life was correlated with more myopic teenage SE (r = −0.57). Eighteen percent of the children had progressive myopia (3-year mean SE progression ≤ −0.75 D/y). Sixty-seven percent of the children with progressive myopia developed HM at the last-follow-up, compared with only 33% in the nonprogressive group (P < 0.001; data not shown). 

Table 2 shows the baseline characteristics of children stratified by teenage HM and AL ≥ 25 mm. Children with teenage HM and AL ≥ 25 mm developed myopia at a younger age and had significantly lower outdoor time compared with children without teenage HM or without AL ≥ 25 mm. These children were also more likely to be Chinese, have mothers with above secondary school education, and with both parents more likely to be myopes. Their baseline SE and AL as well as their 3 and 1-year SE and AL progression were higher compared to those without. Additionally, children with teenage AL ≥ 25 mm were more likely to be boys and taller in height, compared to those with teenage AL < 25 mm. 

Table 2.

 

Comparison of Characteristics in Children With Teenage High Myopia (HM) or AL ≥ 25 mm and Children Without Teenage HM or AL < 25 mm

 

Baseline SE, 3-year SE progression and age of myopia onset were significantly associated with teenage HM (Table 3). The odds ratio (OR) was 11.43 per each SD (−0.3 D/y) increase in annual progression over a period of 3 years. Similarly, baseline AL, 3-year AL progression, and age of myopia onset were significantly associated with teenage AL ≥ 25 mm (Table 3). The OR (95% CI) for teenage HM was 2.40 (95% CI = 1.89 to 3.05) per each SD (−0.3 D/y) increase in SE progression over a period of 1 year and for teenage AL ≥ 25 mm was 1.83 (95% CI = 1.56 to 2.14) per each SD (0.2 mm/y) increase in AL progression over a period of 1 year (data not shown). 

Table 3.

 

Association of Key Risk Factors Alone and in Combination With Teenage High Myopia and AL ≥ 25 mm

 

In linear regression analyses, 3-year SE progression, SE at baseline, and age of myopia onset were associated with teenage SE (Table 4). Three-year SE progression was similar by age at baseline groups, although slightly higher in children ≤ 7 years old (β = −1.20, 95% CI = −1.27 to −1.12) compared with 8 years old (β = −1.06, 95% CI = −1.14 to −0.99) and ≥ 9 years old (β = −1.06, 95% CI = −1.17 to −0.96; data not shown). Myopic life years (β = −0.13, 95% CI = −0.19 to −0.07) was associated with more myopic SE in teenagers (data not shown). Three-year AL progression, baseline AL, and age of myopia onset were associated with teenage AL (Table 4). Myopic life years (β = 0.02, 95% CI = 0.001 to 0.04) was associated with longer AL in teenagers (data not shown). One-year SE progression was also associated with teenage SE (β = −0.56 per each SD increase of −0.30 D/y, 95% CI = −0.62 to −0.51; data not shown) with slightly higher progression in children ≤ 7 years old (β = −0.61, 95% CI = −0.69 to −0.53) compared with 8 years old (β = −0.50, 95% CI = −0.59 to −0.40) and ≥ 9 years old (β = −0.52, 95% CI = −0.63 to −0.42; data not shown). One-year AL progression was also associated with teenage AL (β = 0.16 per each SD increase of 0.2 MM/year, 95% CI = 0.14 to 0.18; data not shown). 

Table 4.

 

Association of Key Risk Factors Alone and in Combination With Teenage SE and AL

 

The predictors of teenage HM were baseline SE with AUC (95% CI) of 0.88 (95% CI = 0.84 to 0.91), 3-year SE progression (0.88, 95% CI = 0.84 to 0.91), 1-year SE progression (0.85, 95% CI = 0.81-0.90), and age of myopia onset (0.83, 95% CI = 0.79 to 0.87). The AUC for outdoor time was 0.64 (95% CI = 0.58 to 0.69), for parental myopia was 0.63 (95% CI = 0.57 to 0.69), for books read per week was 0.50 (95% CI = 0.44 to 0.56), and for age at baseline was 0.50 (95% CI = 0.44 to 0.56). The model combining SE at baseline and 3-year SE progression together with all other risk factors, including age at baseline, gender, race, mother's education, parental myopia, outdoor time, books read per week, and length of follow-up had the highest AUC (0.97, 95% CI = 0.96 to 0.99) for predicting teenage HM (data not shown). However, a combination of the two predictors that could be applicable in clinical settings, namely 3-year SE progression and SE at baseline without other risk factors showed AUC (0.97, 95% CI = 0.95 to 0.98) similar to the model encompassing all risk factors (Fig. 3A). In sensitivity analysis, using the 10-fold cross-validation for the AUC and the bootstrapping of the cross-validated AUC we found that the mean AUC was 0.97 (bootstrap bias corrected 95% CI = 0.94 to 0.98) for a combination of 3-year SE progression and SE at baseline to predict teenage HM (data not shown). The combination of 1-year SE progression and SE at baseline showed a lower AUC of 0.94 (95% CI = 0.91 to 0.96). Other combinations, such as baseline SE with parental myopia showed lower AUC (0.89, 95% CI = 0.86 to 0.92). Age of myopia onset and 3-year SE progression combined with other risk factors were also good predictors of teenage HM (0.92, 95% CI = 0.89 to 0.95). A combination of 3-year SE progression and age of myopia onset without other risk factors, showed an AUC of 0.91 (95% CI = 0.87 to 0.94). The AUC for mild to moderate myopes at baseline (n = 248) to predict teenage HM was 0.91 (95% CI = 0.87 to 0.95) for a combination of 3-year SE progression and baseline SE. 

Figure 3.

 

Receiver operating curves for prediction of teenage high myopia (≤ −5 D) and AL ≥ 25 mm (top tertile cut-point; B) at the last follow-up visit. (A) AUC₁ = 0.97; AUC₂ = 0.88; and AUC₃ = 0.88. In pairwise comparisons of ROC curves, AUC₂ was not significantly different from AUC₃ (P > 0.05); (B) AUC₁ = 0.91; AUC₂ = 0.84; and AUC₃ = 0.67. In pairwise comparisons, all ROC curves were significantly different (all P values < 0.05); AUC, area under the curve; AL, axial length; SE, Spherical equivalent.

For teenage AL ≥ 25 mm the best predictors were baseline AL (0.84, 95% CI = 0.81 to 0.87), 3-year AL progression (0.67, 95% CI = 0.62 to 0.71) and age of myopia onset (0.68, 95% CI = 0.62 to 0.73). The AUC for 1-year AL progression was only 0.60 (95% CI = 0.54 to 0.65). A model combining 3-year AL progression, AL at baseline and other risk factors had an AUC of 0.93 (95% CI = 0.90 to 0.95) for predicting AL ≥ 25 mm (data not shown). However, a combination of two predictors (Fig. 3B), applicable in clinical settings, 3-year AL progression and baseline AL, had AUC (0.91, 95% CI = 0.89 to 0.94) similar to the model encompassing all risk factors. In sensitivity analysis, using the 10-fold cross-validation for the AUC and the bootstrapping of the cross-validated AUC we found that the mean AUC was 0.91 (bootstrap bias corrected 95% CI = 0.89 to 0.94) for a combination of 3-year AL progression and AL at baseline to predict teenage AL ≥ 25 mm (data not shown). The combination of 1-year AL progression and AL at baseline showed slightly lower AUC of 0.89 (95% CI = 0.86 to 0.91). Other combinations, such as 3-year AL progression, age of myopia onset, and other risk factors showed lower AUC for predicting teenage AL ≥ 25 mm (0.71, 95% CI = 0.66 to 0.75; data not shown). The AUC drops further to 0.67 (95% CI = 0.62 to 0.72) for a combination of 3-year AL progression and age of myopia onset. 

Figure 4 shows the probability of teenage HM from baseline to teenage years as a (A) function of 3-year SE progression and as a (B) function of baseline SE, using the two-factor model (i.e., 3-year SE progression and baseline SE) presented in Figure 3A. The three lines show the 25th, 50th, and 75th percentiles of the other risk factor when plotting the probability of teenage HM from baseline to teenage years as a function of 3-year SE progression (D/y) and SE at baseline (D). 

Figure 4.

 

Probability of teenage high myopia (≤ −5 D) from baseline to teenage years as a (A) function of 3-year SE progression and as a (B) function of baseline SE, using the two-factor model (i.e., 3-year SE progression and baseline SE) presented in Figure 3A. The three lines show the 25th, 50th, and 75th percentiles of the other risk factor when plotting the probability of teenage high myopia from baseline to teenage years as a function of A 3-year SE progression (D/y) and B SE at baseline (D).

Discussion

Summary of the Results

In this longitudinal study, including children with a long follow-up, we found that 3 and 1-year childhood myopia progression (6 to 11 years old) were associated with teenage HM (12 to 19 years old). The other factors associated with teenage HM were baseline SE and age of onset of myopia. The combination of 3 or 1-year myopia progression with baseline SE or the surrogate, age of myopia onset was predictive of teenage HM. Similarly, for teenage AL ≥ 25 mm, 3 or 1-year AL progression and baseline AL emerged as top predictors. Our findings suggest the potential clinical value of utilizing information on childhood myopia and AL progression in clinical practice to devise a management plan, in terms of prevention of HM by slowing myopia progression. 

Myopia Progression and Clinical Implications

In this cohort, we observed that a rapid 3 and 1-year SE progression (−0.3 D per year) in children 6 to 11 years old led to an increased teenage mean SE in 12 to 19 years old, as compared to those with lower amounts of progression (less than −0.3 D per year), suggesting that myopia progression may be a useful indicator for the risk of developing HM later on. Although an earlier age of myopia onset is a known risk factor for the development of HM,^18,21 few prospective studies have analyzed myopia progression as a risk factor for HM later on in life. A small retrospective study (n = 59) with a short follow-up showed that children aged 7 to 15 years old with HM, had greater rates of myopia progression, developed myopia earlier, and with initially higher SE levels compared with children with low myopia.³¹ In another study, a randomized clinical trial with a 22 year follow-up, including 240 school children with myopia (aged 8.8 to 12.8 years), myopia progression in childhood during the first follow-up year was identified as a risk factor associated with adulthood HM.³² 

Taken together, those findings may indicate that children with initial fast myopia progression would likely require closer monitoring and follow-up as well as timely clinical treatment interventions, because they are more likely to develop HM later in life.²¹ Thus, the results from our study may be useful to risk-stratify and guide clinical decisions in terms of myopia control management for children. For children at higher risk, more aggressive treatment, including commencing with a higher frequency or concentration of atropine eyedrops or combination treatment (e.g., atropine with multizone contact lenses), may have to be adopted for myopia control. As various myopia control interventions emerge with their own individual risk-benefits profile,³³ our study findings could serve as an adjunctive tool for eyecare professionals to stratify children who are at greater risk of developing teenage HM. 

Myopia Progression Combined With Baseline SE or Age of Myopia Onset

Children with higher myopic progression, higher baseline myopic refractive error, and younger age of myopia onset had more severe teenage myopic refractive error. Baseline SE and age of myopia onset are known risk factors for the development of HM.^18,21,34,35 Previous studies have attempted to establish tools to identify the risk of HM in children. Using SE centile curves, a study showed that children under lower percentiles (10th and 5th centile curves) at younger ages (mean baseline age = 12 years) were more likely to have HM at 15 years old.³⁴ In the COMET, including children aged 6 to 11 years at baseline, younger children with more myopia at baseline had increased risks of developing HM after 7 years of follow-up.²¹ Our present study shows that a combination of SE progression in childhood and baseline SE myopia had good discriminative ability (97%) for teenage HM in SCORM. Using those two factors together may aid clinical decisions in myopia control treatment and counselling for children at higher risk of developing HM. 

AL Progression Combined With Baseline AL or Age of Myopia Onset

Children with higher AL progression in childhood, longer AL at baseline, and younger age of myopia onset had longer teenage AL (≥25 mm). A combination of 3 or 1-year AL progression and baseline AL were significant predictors of teenage AL ≥ 25 mm. A previous study has tried to establish growth charts to identify the risk of developing myopia in children,³⁶ which concluded that the rate of eye growth was twice as high in the children who developed myopia compared to the children who remained hyperopic. Excessive elongation of the globe in adulthood is believed to contribute significantly to the degenerative changes of the retina that can lead to MMD and pathologic myopia, which can result in vision impairment in HM.³⁷ Recent reports showed that severity of adolescent AL is associated with a thinner choroid, which is a known risk factor for MMD.^38,39 However, more studies are necessary to ascertain the role of AL progression in predicting HM and the development of pathologic myopia and its associated complications.⁴⁰ 

Strengths and Limitations

A strength of this study is the longitudinal design with fairly long duration of follow-up; SE and AL were measured at eight different time points yearly with the majority of children having at least three or more follow-up visits. We were therefore able to assess the age of myopia onset and age of HM development, as well as progression rates of SE and AL. However, our study was limited by a loss to follow-up rate of 47%. Participants who attended the last follow-up visit were different compared to those who did not attend, and this may have introduced a selection bias. We also recognize the limitations of variability in A-scan biometry measurements introduced by factors, such as misalignment of beam and variable corneal compression, that may affect the accuracy of AL measurements. Although the combination of baseline SE and 3-year progression had the best AUC, knowing the SE progression over 3 years would be a potential impediment to its use in clinical practice. In situations where 3-year progression information is not available, progression over a shorter duration of time (1-year SE progression) could be considered, as it had a predictive value almost similar to that of 3-year progression, but 1-year progression may not be a stable parameter. In addition, the use of the more myopic eye (worse eye) in the analysis may be seen as a limitation as the clinician may not know at 3 years of follow-up which of the 2 eyes will be the more myopic at 6 to 8 years of follow-up. Nevertheless, the results from this study could serve as the precursor for studying myopia progression in childhood as a potential biomarker for HM and later pathologic myopia in adulthood. Ideally, final SE and AL in adulthood instead of the teenage years would provide more information. It is also important to note that multivariate ORs for SE and AL progression as well as baseline SE and AL showed wide 95% CI, which may be related to the sample size and number of events observed (only 91 children developed HM at the end of the follow-up). The estimated risk reported is also specific to the population studied and may be higher or lower in other populations. Thus, future studies, including larger sample size and longer follow-up until adulthood, may provide more precise estimates. 

Conclusion

In conclusion, our longitudinal cohort study with long follow-up suggests that 3 and 1-year myopia progression in childhood were predictors of teenage HM besides other key risk factors, including baseline SE and age of myopia onset. Teenagers with HM had greater SE progression in childhood, earlier onset of myopia and higher starting SE. A combination of 3 or 1-year myopia progression, baseline SE, and age of myopia onset may predict future HM. These combinations of factors could potentially guide clinical management, particularly in relation to myopia control treatment and counselling, to reduce the risk of developing HM and its associated ocular complications later on in life. Future studies with longer follow-up until adulthood would be helpful in ascertaining the effect of myopia progression in childhood on the risk of pathologic myopia development in adulthood. 

Acknowledgments

The authors thank Chye-Fong Peck for data collection. 

Supported by the Singapore Government under the Industry Alignment Fund - Industry Collaboration Projects (IAF-ICP) Grant (I1901E0038), the National Medical Research Council Individual Research Grant (NMRC/0975/2005), and Johnson & Johnson Vision. 

Disclosure: C. Lanca, None; L.-L. Foo, None; M. Ang, None; C.S. Tan, None; B. Kathrani, Johnson & Johnson Vision (E); H.M. Htoon, None; D. Tan, None; Q.V. Hoang, None; N. Brennan, Johnson & Johnson Vision (E); S.-M. Saw, None; C. Sabanayagam, None  

Amended April 23, 2021: In Table 2, in the Teenage High Myopia section, the value listed in the No column for Boys has been corrected from 9082.07 to 90.0.