June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
IMPAIREMENT OF CHORIORETINAL VASCULATURE IN PATIENTS WITH INTERMEDIATE AGE-RELATED MACULAR DEGENERATION
Author Affiliations & Notes
  • Rita Flores
    Centro Hospitalar de Lisboa Central EPE, Lisboa, Lisboa, Portugal
  • Angela Carneiro
    Centro Hospitalar Universitario de Sao Joao, Porto, Porto, Portugal
  • Guilherme Nery
    OPHTAHLMOLOGY - MEDICAL RETINA, Centro Hospitalar de Lisboa Central EPE, Lisboa, Lisboa, Portugal
  • Sandra Tenreiro
    Universidade Nova de Lisboa, Lisboa, Lisboa, Portugal
  • Miguel Seabra
    Universidade Nova de Lisboa, Lisboa, Lisboa, Portugal
  • Footnotes
    Commercial Relationships   Rita Flores, None; Angela Carneiro, None; Guilherme Nery, None; Sandra Tenreiro, None; Miguel Seabra, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 93. doi:
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      Rita Flores, Angela Carneiro, Guilherme Nery, Sandra Tenreiro, Miguel Seabra; IMPAIREMENT OF CHORIORETINAL VASCULATURE IN PATIENTS WITH INTERMEDIATE AGE-RELATED MACULAR DEGENERATION. Invest. Ophthalmol. Vis. Sci. 2021;62(8):93.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Age related macular degeneration (AMD) is a multifactorial disease leading to loss of central vision; even though its complete pathogenesis is still unclear aging, genetics and smoking are the most important risk factors. Local hemodynamics may play a crucial role in the manifestation and progression of AMD pathologies.

Methods : A total of 179 eyes were recruited to this study, 149 eyes with intermediate AMD and 30 healthy controls. A total of 127 eyes were eligible for image binarization and included in the final analysis: Group 1: AMD eyes n=102 (80%) and Group 2: healthy controls n=25 (20%). 50 eyes presented soft or cuticular drusen (Group 1A), 35 eyes reticular pseudodrusen (Group 1B) and 17 eyes both types of drusens (Group 1C). Mean age in years in study sample was 77.9 ±8.8 and the majority of the participants were women (70%).
Choroid and retinal vascular quantitative parameters were evaluated in an intermediate AMD population and compared with a control group. Spectral domain optic coherence tomography (SD-OCT) with enhanced depth imaging (EDI) and optic coherence tomography angiography (OCT-A), were acquired using OCT SPECTRALIS (Heidelberg Engineering, Heidelberg, Germany). Image binarization was used to obtain quantitative data of choroid and retinal capillary plexus evaluation.

Results : Considering choroid vascular parameters after binarization we found that Total subfoveal Choroidal Area (TCA) in Group 1 was 0.22 ±0.066 mm2 and 0.29±0.083 mm2 in Group 2. Luminal Area (LA) was also reduced in Group 1 (0,1552 ±0,043 mm2) compared with Group 2 (0,203±0,053 mm2) and those differences were statistically significant (p<0.05). Regarding retinal capillary perfusion there was a trend to reduced vascular parameters in Group 1A in both superficial capillary plexus (LA: 9.44±1.1 mm2) and in deep capillary plexus (LA: 9.80±0.89 mm2) compared with Group 1B (LA: 10.13±1.3 mm2 and 10.29±1.1 mm2, respectively).

Conclusions : Our study corroborates that the chorioretinal vascular network are impaired in intermediate AMD patients. Retinal and choroidal vascular parameters could be attractive new prognostic markers for intermediate AMD. Future therapeutic approaches may target this vascular dysfunction and prevent disease progression in early and intermediate stages.

This is a 2021 ARVO Annual Meeting abstract.

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