June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Correlation between photoreceptor density in adaptive optics imaging with retinal structure and sensitivity in autoimmune retinopathy
Author Affiliations & Notes
  • Wataru Matsumiya
    Byers Eye Institute, Stanford University, California, United States
  • Amir Akhavanrezayat
    Byers Eye Institute, Stanford University, California, United States
  • Gunay Uludag
    Byers Eye Institute, Stanford University, California, United States
  • Cigdem Yasar
    Byers Eye Institute, Stanford University, California, United States
  • Hashem Ghoraba
    Byers Eye Institute, Stanford University, California, United States
  • Azadeh Mobasserian
    Byers Eye Institute, Stanford University, California, United States
  • Irmak Karaca
    Byers Eye Institute, Stanford University, California, United States
  • Brandon Chau Lam
    Byers Eye Institute, Stanford University, California, United States
  • Brandon Pham
    Byers Eye Institute, Stanford University, California, United States
  • Jaclyn Joyce Hwang
    Byers Eye Institute, Stanford University, California, United States
  • Rubbia Afridi
    Byers Eye Institute, Stanford University, California, United States
  • Muhammad Sohail Halim
    Byers Eye Institute, Stanford University, California, United States
    Ocular Imaging Research and Reading Center, California, United States
  • Diana V Do
    Byers Eye Institute, Stanford University, California, United States
  • Yasir J Sepah
    Byers Eye Institute, Stanford University, California, United States
  • Quan Dong Nguyen
    Byers Eye Institute, Stanford University, California, United States
  • Footnotes
    Commercial Relationships   Wataru Matsumiya, None; Amir Akhavanrezayat, None; Gunay Uludag, None; Cigdem Yasar, None; Hashem Ghoraba, None; Azadeh Mobasserian, None; Irmak Karaca, None; Brandon Lam, None; Brandon Pham, None; Jaclyn Hwang, None; Rubbia Afridi, None; Muhammad Sohail Halim, None; Diana Do, None; Yasir Sepah, None; Quan Nguyen, None
  • Footnotes
    Support  Kobe University Long Term Oversea Visit Program for Young Researchers, Japan Eye Bank Association Oversea Research Program
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 8. doi:
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      Wataru Matsumiya, Amir Akhavanrezayat, Gunay Uludag, Cigdem Yasar, Hashem Ghoraba, Azadeh Mobasserian, Irmak Karaca, Brandon Chau Lam, Brandon Pham, Jaclyn Joyce Hwang, Rubbia Afridi, Muhammad Sohail Halim, Diana V Do, Yasir J Sepah, Quan Dong Nguyen; Correlation between photoreceptor density in adaptive optics imaging with retinal structure and sensitivity in autoimmune retinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):8.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Autoimmune Retinopathy (AIR) is a rare disease with progressive retinal degeneration which does not have a gold standard to monitor disease activity. Adaptive optics (AO) technology is recently developed to depict a photoreceptor in retina. Our aim is to evaluate utility of an AO camera in comparison with microperimetry (MP) and spectral-domain optical coherence tomography (SD-OCT) in AIR.

Methods : Three eyes of 3 patients with a confirmed diagnosis of AIR by clinical and serologic findings were assessed. AO images (rtx1, Imagine Eyes, France) of the central 4°x 4°field (not including 0.5°x 0.5° field of fovea) , MP with 4-2 staircase threshold strategy (MAIA Centervue, Italy), and OCT (Spectralis Heidelberg, Germany) were analyzed after merging images using Adobe Photoshop CS6 (Adobe Systems, San Jose, CA). A correlation was investigated among photoreceptor parameters [cone density (CD), regularity, dispersion, and spacing] in AO images, retinal sensitivity (RS) in MP, and outer retinal thickness (ORT) on OCT which were obtained at two separate time-points. AO images from 2 visits were automatically registered and parameters of photoreceptors were calculated with manual method (AO detect 3.0, Imagine Eyes), which had an excellent intraclass correlation coefficient (>0.90) in the prior study.

Results : A total of 22 regions of interest on AO, MP, and OCT images in 1 female (65 yo) and 2 males (14 yo and 56 yo) were assessed. At baseline, mean value of RS and ORT was 18.4±11.4dB and 96.2±49.9µm, respectively. Mean values of AO parameters were 1481±409/deg2 (CD), 86.7±5.7% (regularity), 17.6±3.7% (dispersion), and 1.76±0.27 arcminute (spacing). Highest correlation of both RS and ORT were with CD (ρ=0.78, P<0.0001 and ρ=0.81, P<0.0001, respectively), followed by spacing (ρ=-0.75, P=0.0001 and ρ=-0.79, P<0.0001, respectively). Mean changes of CD, RS, and ORT between two time-points (range of interval: 2-5 months) were -0.9±5.1 dB, -92±157 /deg2, and 15.5±26.3 µm, respectively. The correlation of changes in CD with RS, and ORT were 0.40 (P = 0.063) and 0.57 (P = 0.006), respectively.

Conclusions : Cone density appeared to have a significant correlation with retinal sensitivity (as measured by MP) and retinal structure (as measured by OCT). Therefore, measuring the cone density using manual method in AO images may be useful to assess retinal function in AIR patients.

This is a 2021 ARVO Annual Meeting abstract.

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