Sensitivity to netilmicin in infectious keratitis in Mexico in the period 2009 to 2017.

Abstract

Purpose : The 4th generation quinolones are the treatment of choice for infectious bacterial keratitis, however, recent reports suggest an increase in resistance to these drugs, so it is important to recognize the sensitivity of other drugs and compare them with the gold standard

Methods : A cross-sectional study including a consecutive analysis of patients records with a diagnosis of bacterial keratitis with a positive culture and antibiogram report between January 2009 and December 2017 of the Cornea department of the Dr. Luis Sánchez Bulnes Hospital of the Association to Avoid Blindness in Mexico were included. Demographic data, Gram stain, bacterial profile and antimicrobial resistance were analyzed.

Results : In the studied period, a total of 794 (49.53%) cases with a positive culture were included. 27.1% of patients had polymicrobial infections so 1034 cultures were evaluated. 52.3% of the patients were male, the mean age was 48.28 ± 20.43 years (range 1 to 97 years). 81.33% (841) of the cultures were gram positive. The antibiotic with the highest sensitivity for gram positive was Netilmicin (93.23%), followed by Moxifloxacin (92.98%) and Gatifloxacin (92.39%). For gram negative cultures again Netilmicin had the highest sensitivity (88.08%), followed by Gatifloxacin (86.01%) and Moxifloxacin (84.45%).

Conclusions : Gram positive bacterias are the most common cause of infectious keratitis, Staphylococcus and Pseudomonas as the most common isolates. Netilmicine and 4th generation flouroquinolones had a very good sensibility for both types of bacteria.

This is a 2021 ARVO Annual Meeting abstract.