June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Evaluation of different OCT systems in quantitative imaging of Schlemm's Canal in human
Author Affiliations & Notes
  • Xuan Wu
    Ocular Imaging, Singapore Eye Research Institute, Singapore, Singapore
    SERI-NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University, Singapore, Singapore, Singapore
  • Jinyuan Gan
    Duke-NUS Medical School, Singapore, Singapore
  • Adeline Lam
    Duke-NUS Medical School, Singapore, Singapore
  • Jacqueline Chua
    Ocular Imaging, Singapore Eye Research Institute, Singapore, Singapore
    Duke-NUS Medical School, Singapore, Singapore
  • Damon Wong
    SERI-NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University, Singapore, Singapore, Singapore
    Ocular Imaging, Singapore Eye Research Institute, Singapore, Singapore
  • Bingyao Tan
    SERI-NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University, Singapore, Singapore, Singapore
  • Leopold Schmetterer
    Ocular Imaging, Singapore Eye Research Institute, Singapore, Singapore
    SERI-NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University, Singapore, Singapore, Singapore
  • Xinwen Yao
    SERI-NTU Advanced Ocular Engineering (STANCE), Nanyang Technological University, Singapore, Singapore, Singapore
  • Footnotes
    Commercial Relationships   Xuan Wu, None; Jinyuan Gan, None; Adeline Lam, None; Jacqueline Chua, None; Damon Wong, None; Bingyao Tan, None; Leopold Schmetterer, None; Xinwen Yao, None
  • Footnotes
    Support  National Medical Research Council Grants CG/C010A/2017, OFLCG/004C/2018 and TA/MOH-000249-00/2018 and Duke-NUS Medical School (Duke-NUS-KP(Coll)/2018/0009A), Singapore.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 392. doi:
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      Xuan Wu, Jinyuan Gan, Adeline Lam, Jacqueline Chua, Damon Wong, Bingyao Tan, Leopold Schmetterer, Xinwen Yao; Evaluation of different OCT systems in quantitative imaging of Schlemm's Canal in human. Invest. Ophthalmol. Vis. Sci. 2021;62(8):392.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The morphology of SC is believed to be closely related to glaucoma and accurate assessment on the dimension of Schlemm’s Canal (SC) is vital. Optical coherence tomography (OCT) enables high-resolution, three-dimensional (3D) imaging of SC in living humans. This study quantitatively compares the performance of three commercial OCT systems in SC imaging and analyzes the impact factors that may affect the image quality as well as the morphological analysis of SC therefrom. Our study provides a guideline to choose an optimized OCT system for better visualization of SC.

Methods : Ten healthy subjects were imaged using three OCT machines: ZEISS Cirrus 5000 (840nm, spectral-domain (SD)-OCT), ZEISS Plex Elite 9000 (1060nm, swept-source (SS)-OCT) and Tomey Casia (1310nm, SS-OCT). For each subject, both eyes underwent two cubic scans by each machine, one on the nasal quadrant and the other temporal. The B-scan showing the largest SC was chosen and processed to obtain SC dimensional metrics. The SC contrast was investigated by quantitative comparison. Four morphological metrics, including the cross-sectional area (CSA), the perimeter, the longest, and shortest diameters of SC, were extracted via manual segmentation. The difference between the three OCT systems were analyzed.

Results : The CSAs were significantly different between different machines (Cirrus - Casia: Δ=1763.89µm2, p<0.001; Plex - Casia: Δ=1026.21µm2, p<0.001; Cirrus - Plex: Δ=737.68µm2, p=0.003), as well as the longest diameters (Cirrus - Casia: Δ=56.50µm, p<0.001; Plex - Casia: Δ=39.29µm, p<0.001; Cirrus - Plex: Δ=17.21µm, p=0.031). The SC perimeter measured from Casia was significantly different compared to that from Cirrus or Plex (Cirrus – Casia: Δ=100.90µm, p<0.001; Plex – Casia: Δ=39.29µm, p<0.001). The shortest diameter measured from Cirrus and Casia was significantly different (Δ=-3.9µm, p=0.039). The Michelson contrast was seen highest in Cirrus (0.63±0.05), mediocre in Plex (0.57±0.06), while lowest in Casia (0.40±0.07). Based on visual assessment, the 1060nm system showed a good balance in angle delineation and SC visualization. Conversely, the 840nm system displayed good performance in SC visualization while the 1310nm system excelled in angle delineation.

Conclusions : The wavelength and resolution of the anterior segment OCT system may affect the visualization as well as the quantitative assessment of SC morphology.

This is a 2021 ARVO Annual Meeting abstract.

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