June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Applying Normal PedEyeQ Thresholds to Define Reduced Quality of Life in Children with Visual Impairment
Author Affiliations & Notes
  • Suzanne M Wernimont
    Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
  • David A Leske
    Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
  • Sarah R Hatt
    Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
  • Yolanda S Castañeda
    Retina Foundation of the Southwest, Dallas, Texas, United States
  • Christina S Cheng-Patel
    Retina Foundation of the Southwest, Dallas, Texas, United States
  • Erick D Bothun
    Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
  • Eileen E Birch
    Retina Foundation of the Southwest, Dallas, Texas, United States
    Ophthalmology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
  • Jonathan M Holmes
    Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States
    Ophthalmology and Vision Science, University of Arizona-Tucson, Tucson, Arizona, United States
  • Footnotes
    Commercial Relationships   Suzanne Wernimont, None; David Leske, None; Sarah Hatt, None; Yolanda Castañeda, None; Christina Cheng-Patel, None; Erick Bothun, None; Eileen Birch, None; Jonathan Holmes, None
  • Footnotes
    Support  National Institutes of Health Grants EY024333 (JMH, PI & EEB, Co-I), EY011751 (JMH) and EY022313 (EEB), and Mayo Foundation, Rochester, Minnesota.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 140. doi:
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      Suzanne M Wernimont, David A Leske, Sarah R Hatt, Yolanda S Castañeda, Christina S Cheng-Patel, Erick D Bothun, Eileen E Birch, Jonathan M Holmes; Applying Normal PedEyeQ Thresholds to Define Reduced Quality of Life in Children with Visual Impairment. Invest. Ophthalmol. Vis. Sci. 2021;62(8):140.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The Pediatric Eye Questionnaire (PedEyeQ) assesses eye-related quality of life (ER-QOL) and functional vision in children with any eye condition. Previous studies have compared mean scores in clinical and control populations, but not whether it is meaningful to apply normal thresholds to identify individuals with reduced ER-QOL and functional vision. We evaluated PedEyeQ scores in children with bilateral visual impairment (VI).

Methods : 48 children (22, 0-4 years, 18, 5-11 years and 8, 12-17 years) with bilateral VI (best-eye acuity worse than 20/70) and 310 visually normal controls (104, 0-4 years, 104, 5-11 years and 102, 12-17 years) were prospectively enrolled. Children aged 5-17 years completed the Child PedEyeQ (Functional Vision, Bothered by Eyes/vision, Social, and Frustration/worry domains). Parents completed Proxy PedEyeQ (0-4 years: Functional Vision, Bothered by Eyes/Vision, Social; 5-17 years: same domains plus Frustration/Worry and Eye Care) and Parent PedEyeQ (Impact on Parent and Family, Worry about Child’s Eye Condition, Worry about Child’s Self-perception/Interactions, Worry about Child’s Functional Vision). PedEyeQ domains were Rasch-scored and converted to 0-100. The 5th percentile of scores in the normal cohort defined the “reduced” threshold for each domain in each age group. Proportions with reduced scores were calculated.

Results : Proportions of VI subjects with reduced Child scores ranged from 78% (Functional Vision) to 39% (Frustration/worry) for 5-11 years and from 100% (Functional vision, Frustration/worry) to 88% (Bothered by Eyes/vision, Social) for 12-17 years. Proportions with reduced Proxy scores ranged from 100% (Functional Vision, Bothered by Eyes/Vision) to 55% (Social) for 0-4 years, 94% (Functional Vision) to 61% (Frustration/Worry, Eye Care) for 5-11 years, and 100% (all except Frustration/Worry) to 88% for 12-17 years. Proportions with reduced Parent scores were 95% or 100% for 0-4 years and 83% to 100% for 5-11 years; all domain scores (100%) were reduced for 12-17 years.

Conclusions : A high proportion of visually impaired children and their parents have reduced PedEyeQ domain scores, supporting the application of a normal threshold to identify individuals with reduced ER-QOL and functional vision. Nevertheless, variability of scores by self-report in young children may create challenges for interpreting domain scores in 5- to 11-year-olds.

This is a 2021 ARVO Annual Meeting abstract.

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