June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Predictors of retinal pigment epithelium tear development after treatment for neovascular age-related macular degeneration using swept source optical coherence tomography angiography
Author Affiliations & Notes
  • Satoshi Yasuhara
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Manabu Miyata
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Sotaro Ooto
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Hiroshi Tamura
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Naoko Ueda
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Akihito Uji
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Yuki Muraoka
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Masahiro Miyake
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Ayako Takahashi
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Tomotaka Wakazono
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Kenji Yamashiro
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
    Department of Ophthalmology, Otsu Sekijuji Byoin, Otsu, Shiga, Japan
  • Akitaka Tsujikawa
    Department of Ophthalmology and Visual Sciences, Kyoto Daigaku, Kyoto, Japan
  • Footnotes
    Commercial Relationships   Satoshi Yasuhara, None; Manabu Miyata, None; Sotaro Ooto, None; Hiroshi Tamura, None; Naoko Ueda, None; Akihito Uji, None; Yuki Muraoka, None; Masahiro Miyake, None; Ayako Takahashi, None; Tomotaka Wakazono, None; Kenji Yamashiro, None; Akitaka Tsujikawa, None
  • Footnotes
    Support  a grant-in-aid for scientific research (no. 18K09444) from the Japan Society for the Promotion of Science, Tokyo, Japan
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 106. doi:
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      Satoshi Yasuhara, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda, Akihito Uji, Yuki Muraoka, Masahiro Miyake, Ayako Takahashi, Tomotaka Wakazono, Kenji Yamashiro, Akitaka Tsujikawa; Predictors of retinal pigment epithelium tear development after treatment for neovascular age-related macular degeneration using swept source optical coherence tomography angiography. Invest. Ophthalmol. Vis. Sci. 2021;62(8):106.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To investigate predictors of retinal pigment epithelium (RPE) tear development after anti-vascular endothelial growth factor (VEGF) therapy or photodynamic therapy (PDT) for neovascular age-related macular degeneration (AMD) using swept source optical coherence tomography angiography (SS-OCTA)

Methods : This prospective, observational study included treatment-naïve eyes with neovascular AMD in consecutive patients who were followed for 1 year after receiving the initial treatment at Kyoto University Hospital between June 2017 and June 2019 and who underwent SS-OCTA examinations (PLEX Elite 9000, Dublin, California) prior to the treatment. Eligible eyes were classified into eyes with or without RPE tear development during 1-year observation period. They were matched for 1:2 ratio using propensity scores. The area of choroidal neovascularization (CNV) and RPE detachment (PED) were measured from OCTA and optical coherence tomography (OCT) en face images, respectively. Specific OCTA-derived parameters, which represent vessel caliber and complexity of CNV, were also analyzed.

Results : In 8 of 164 eyes (4.9%), RPE tear developed (RPE tear group). After matching, 16 eyes without RPE tear were analyzed (no RPE tear group). The ratio of CNV/PED area was significantly lower in the RPE tear group than in the no RPE tear group (0.24 ± 0.13 vs. 0.52 ± 0.26, P = 0.01). The PED area was broader (9.07 ± 5.79 mm2 vs. 4.29 ± 5.47 mm2, P = 0.01), and PED height was greater in the RPE tear group (413.6 ± 224.4 µm vs. 231.8 ± 218.3 µm, P = 0.02). There were no significant differences in specific OCTA-derived parameters between the two groups.

Conclusions : Neovascular AMD with pre-treatment broad PED, high PED, and small CNV area relative to PED area may have a high risk of RPE tear development after the therapy. Vessel caliber or complexity of CNV may not be associated with RPE tear development.

This is a 2021 ARVO Annual Meeting abstract.

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