June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Sensitivity of a combined OCT index in glaucomatous eyes
Author Affiliations & Notes
  • Jordan Wilson
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Thomas Callan
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Sophia Yu
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Mary K Durbin
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Ian P Conner
    Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • Robert Chang
    Ophthalmology, Byers Eye Institute, Palo Alto, California, United States
  • Tin Aung
    Singapore Eye Research Institute, Singapore, Singapore
  • Gary C Lee
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Footnotes
    Commercial Relationships   Jordan Wilson, Carl Zeiss Meditec Inc. (E); Thomas Callan, Carl Zeiss Meditec Inc. (E); Sophia Yu, Carl Zeiss Meditec Inc. (E); Mary Durbin, Carl Zeiss Meditec Inc. (E); Ian P Conner, Carl Zeiss Meditec Inc. (F), Ivantis (C), Ocugenix (I); Robert Chang, Carl Zeiss Meditec Inc. (F); Tin Aung, Carl Zeiss Meditec Inc. (F); Gary Lee, Carl Zeiss Meditec Inc. (E)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 995. doi:
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      Jordan Wilson, Thomas Callan, Sophia Yu, Mary K Durbin, Ian P Conner, Robert Chang, Tin Aung, Gary C Lee; Sensitivity of a combined OCT index in glaucomatous eyes. Invest. Ophthalmol. Vis. Sci. 2021;62(8):995.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Glaucoma is often assessed with optical coherence tomography (OCT) and perimetry to provide clinicians a large number of quantitative parameters that aid in diagnosis. The OCT Early Glaucoma Diagnostic Structural Index (EGDSI), was previously proposed and validated providing a combined structural index for the detection of early glaucoma1,2. In this retrospective clinical study, we compared the sensitivity of EGDSI to individual OCT summary parameters in a cohort with a range of glaucoma severity.

Methods : Retrospective OCT and visual field (VF) data were analyzed from a previous study including 74 eyes of 74 glaucoma subjects, using CIRRUS™ HD-OCT (ZEISS, Dublin, CA) and HFA™ II-i (ZEISS, Dublin, CA)3. At each visit, Optic Disc 200x200 and Macula 200x200 cube scans and SITA Standard 24-2 VFs were acquired. Sixteen OCT summary parameters (Rim Area, Cup-to-Disc area Ratio (CDR), vertical diameter CDR (vCDR), Average and four Quadrant RNFL thicknesses, Average, Minimum, and six Sectoral GCIPL thicknesses) were extracted for comparison and to calculate EGSDI from the last qualified visit data as previously described1,2. A VF mean deviation (MD) cutoff of -4 dB was used to separate early and non-early glaucoma as done previously2. Sensitivity at specificities of 95% and 99% were determined for EGDSI and component OCT parameters based on cut-off values from the CIRRUS reference database. McNemar’s test was used to compare individual results to the EGDSI.

Results : Mean ± standard deviation (SD) age was 63.6±10.1 (range: 35.7 to 79.6) years. Mean ± SD VF MD was -3.9±4.1 (range: -18.2 to 1.2) dB. Sensitivities for EGDSI were 81.1% and 67.6% for 95% and 99% specificity, respectively (see Table 1). The best individual parameters were: a) GCIPL Minimum (70.3% and 54.1%); b) RNFL Inferior (64.9% 54.1%); and c) Rim Area (56.8% and 36.5%). Comparable sensitivities were seen in the split cohorts, though values for EGDSI and GCIPL Minimum became more comparable in non-early glaucoma (See Table 2).

Conclusions : The combined EGDSI shows improved sensitivity in early glaucoma and comparable sensitivity in non-early glaucoma eyes in this study. As such, EGDSI may be a useful aid for the detection in a clinical range of glaucoma.

References
[1] Mwanza et al. IOVS 2013; 54(13).
[2] Mwanza et al. TVST 2018; 7(2).
[3] Durbin et al. IOVS 2020; 61(9): Abstract PB00106.

This is a 2021 ARVO Annual Meeting abstract.

 

Table 1. Summary of sensitivities for all eyes

Table 1. Summary of sensitivities for all eyes

 

Table 2. Summary of sensitivities for split cohorts

Table 2. Summary of sensitivities for split cohorts

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