June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
The Association of Traffic-Related Air Pollution and Perfusion of the Peripapillary Retina in African Americans
Author Affiliations & Notes
  • Dominic Joseph Grisafe
    Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Meredith Franklin
    Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Darryl Nousome
    Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Roberta McKean-Cowdin
    Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Bruce Burkemper
    Preventive Medicine, University of Southern California, Los Angeles, California, United States
  • Mina Torres
    Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, United States
  • Ryuna Chang
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Jae Lee
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Grace Richter
    Roski Eye Institute, University of Southern California, Los Angeles, California, United States
  • Rohit Varma
    Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Dominic Grisafe, None; Meredith Franklin, None; Darryl Nousome, None; Roberta McKean-Cowdin, None; Bruce Burkemper, None; Mina Torres, None; Ryuna Chang, None; Jae Lee, None; Grace Richter, Carl Zeiss Meditec, Inc. (F); Rohit Varma, None
  • Footnotes
    Support  NIH National Institute of Environmental Health Sciences Grant T32 ES013678; NIH National Institute on Aging Grant T32 AG000037; NIH National Eye Institute Grant K23 EY-027855; NIH National Eye Institute Grant U10 EY-023575; Unrestricted grant from the Research to Prevent Blindness, New York, New York
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 56. doi:
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      Dominic Joseph Grisafe, Meredith Franklin, Darryl Nousome, Roberta McKean-Cowdin, Bruce Burkemper, Mina Torres, Ryuna Chang, Jae Lee, Grace Richter, Rohit Varma; The Association of Traffic-Related Air Pollution and Perfusion of the Peripapillary Retina in African Americans. Invest. Ophthalmol. Vis. Sci. 2021;62(8):56.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : African Americans have a greater prevalence of open angle glaucoma (OAG) and exposure to traffic-related air pollution (TRAP). We investigated whether glaucomatous vascular changes were related to exposure of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameter < 2.5 µm (PM2.5) in the African American Eye Disease Study (AFEDS).

Methods : The AFEDS is a cross-sectional, population-based cohort study conducted from 2014–2018 of 6,347 self-reported African Americans aged 40 years or older residing in 32 US census tracts of Inglewood, California. Participants completed in-home interviews and detailed eye exams including optical coherence tomography angiography (OCTA) imaging. Perfusion of radial peripapillary capillaries in healthy eyes was measured as vessel area density (VAD) calculated over 6x6 mm images centered on the optic nerve head. Exposures to NO2 (ppb) and PM2.5 (µg/m3) were estimated from spatiotemporal generalized additive models created using the EPA’s Air Quality System data. Hierarchical linear regression models of VAD on NO2 and PM2.5 were progressively adjusted for (1) sex and age; (2) education, employment, and income; (3) body mass index, glycated hemoglobin, duration of diabetes, systolic blood pressure, ever-smoking, and health insurance; and (4) axial length, OCTA signal strength, and vision insurance.

Results : AFEDS participants (n = 1,009) were on average 58.3 years old, 64.2% female, 50% employed, 61% earned ≥ $40,000, and had 14.3 years of education. In the first three hierarchical models, lower VAD was associated with mean NO2 and PM2.5 exposure (P < 0.05). Associations in the fully adjusted models were not significant, but in the expected direction; VAD was -0.160 (95% CI: -0.377, 0.056) percent lower per 10-ppb increase in NO2, and -0.271 (95% CI: -0.588, 0.045) percent lower per 10 µg/m3 increase in PM2.5. Differences in VAD equated to an increased age of 1.6 years for NO2 and 2.7 years for PM2.5.

Conclusions : We found an inverse relationship between peripapillary perfusion and TRAP after adjusting for sociodemographic and clinical covariates. Associations further adjusted for ophthalmic measures were not significant, which may be due to a small true effect and overadjustment. These findings complement an emerging body of evidence that TRAP may be related to eye disease and could contribute to disparities in OAG for African Americans.

This is a 2021 ARVO Annual Meeting abstract.

 

 

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