June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Improvement of retinal tissue perfusion after circuit resistance training in healthy older adults
Author Affiliations & Notes
  • Jianhua Wang
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
  • Juan Zhang
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    School of Ophthalmology and Optometry, Wenzhou Medical University, China
  • Keri Strand
    Department of Kinesiology and Sports Science, University of Miami, Coral Gables, Florida, United States
  • Matthew Totillo
    Department of Kinesiology and Sports Science, University of Miami, Coral Gables, Florida, United States
  • Qi Chen
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    School of Ophthalmology and Optometry, Wenzhou Medical University, China
  • Joseph F. Signorile
    Department of Kinesiology and Sports Science, University of Miami, Coral Gables, Florida, United States
  • Hong Jiang
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States
    Department of Neurology, University of Miami Miller School of Medicine, Florida, United States
  • Footnotes
    Commercial Relationships   Jianhua Wang, None; Juan Zhang, None; Keri Strand, None; Matthew Totillo, None; Qi Chen, None; Joseph F. Signorile, None; Hong Jiang, None
  • Footnotes
    Support  NIH Center Grant P30 EY014801,NINDS 1R01NS111115-01,the Ed and Ethel Moor Alzheimer's Disease Research Program (Florida Health, 20A05), Research to Prevent Blindness (RPB),he Wenzhou Municipal Science and Technology Bureau (G20190023), and Zhejiang Provincial Natural Science Foundation (LY21F020030).
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2828. doi:
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    • Get Citation

      Jianhua Wang, Juan Zhang, Keri Strand, Matthew Totillo, Qi Chen, Joseph F. Signorile, Hong Jiang; Improvement of retinal tissue perfusion after circuit resistance training in healthy older adults. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2828.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the retinal tissue perfusion (RTP) and its relation to cognitive function in healthy older people after an 8-week high-speed circuit resistance training program (HSCT).

Methods : Eleven subjects in the HSCT group and seven age-matched non-training controls (CON) were recruited. The HSCT group trained 3 times per week for 8 weeks, while CON performed no formal training. One eye of each subject in both groups was imaged at baseline and at an 8-week follow-up, using a Retinal Function Imager to measure retinal blood flow (RBF). Retinal tissue perfusion (RTP) was calculated as RBF divided by the corresponding tissue volume. Cognitive function was assessed during both visits using the NIH Toolbox Fluid Cognition Battery.

Results : RTP was 2.99 ± 0.91 nl s-1 mm-3 (mean ± SD) at baseline and significantly increased to 3.77 ± 0.86 nl s-1 mm-3 after training (P < 0.001) in the HSCT group, reflecting an increase of 26%. In the HSCT group, the Pattern Comparison Processing Speed Test (PAT) and Fluid Cognition Composite Score (FCS) were significantly increased after HSCT (P = 0.01). Furthermore, the changes in Flanker Inhibitory Control and Attention Test (FLNK) were positively correlated to increases in RTP (r = 0.80, P = 0.003).

Conclusions : This is the first prospective study to demonstrate that the increased RTP after HSCT was related to improved cognition in cognitively-normal elders, indicating RTP could be an imaging marker for monitoring cognitive changes due to physical activity in the elderly.

This is a 2021 ARVO Annual Meeting abstract.

 

Fig. 1 RTP, RBF, and tissue volume in the HSCT and CON groups at baseline and follow-up. a. In the HSCT group, RTP was significantly increased after 8-week training (P < 0.001), b. In the HSCT group, RBF was significantly increased at the follow-up (P < 0.001). c. there was no change in the tissue volume (P = 0.90) in the HSCT group.

Fig. 1 RTP, RBF, and tissue volume in the HSCT and CON groups at baseline and follow-up. a. In the HSCT group, RTP was significantly increased after 8-week training (P < 0.001), b. In the HSCT group, RBF was significantly increased at the follow-up (P < 0.001). c. there was no change in the tissue volume (P = 0.90) in the HSCT group.

 

Fig. 2 The changes in cognitive performances for each subject in the HSCT group and CON group before and after 8-week training. a. The changes in PAT scores at baseline and follow-up for each subject in the HSCT group. b. The changes in FCS scores at baseline and follow-up for each subject in the HSCT group. c. The changes in PAT scores at baseline and follow-up for each subject in the CON group. d. The changes in FCS scores at baseline and follow-up for each subject n the CON group.

Fig. 2 The changes in cognitive performances for each subject in the HSCT group and CON group before and after 8-week training. a. The changes in PAT scores at baseline and follow-up for each subject in the HSCT group. b. The changes in FCS scores at baseline and follow-up for each subject in the HSCT group. c. The changes in PAT scores at baseline and follow-up for each subject in the CON group. d. The changes in FCS scores at baseline and follow-up for each subject n the CON group.

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