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Jianhua Wang, Juan Zhang, Keri Strand, Matthew Totillo, Qi Chen, Joseph F. Signorile, Hong Jiang; Improvement of retinal tissue perfusion after circuit resistance training in healthy older adults. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2828.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the retinal tissue perfusion (RTP) and its relation to cognitive function in healthy older people after an 8-week high-speed circuit resistance training program (HSCT).
Eleven subjects in the HSCT group and seven age-matched non-training controls (CON) were recruited. The HSCT group trained 3 times per week for 8 weeks, while CON performed no formal training. One eye of each subject in both groups was imaged at baseline and at an 8-week follow-up, using a Retinal Function Imager to measure retinal blood flow (RBF). Retinal tissue perfusion (RTP) was calculated as RBF divided by the corresponding tissue volume. Cognitive function was assessed during both visits using the NIH Toolbox Fluid Cognition Battery.
RTP was 2.99 ± 0.91 nl s-1 mm-3 (mean ± SD) at baseline and significantly increased to 3.77 ± 0.86 nl s-1 mm-3 after training (P < 0.001) in the HSCT group, reflecting an increase of 26%. In the HSCT group, the Pattern Comparison Processing Speed Test (PAT) and Fluid Cognition Composite Score (FCS) were significantly increased after HSCT (P = 0.01). Furthermore, the changes in Flanker Inhibitory Control and Attention Test (FLNK) were positively correlated to increases in RTP (r = 0.80, P = 0.003).
This is the first prospective study to demonstrate that the increased RTP after HSCT was related to improved cognition in cognitively-normal elders, indicating RTP could be an imaging marker for monitoring cognitive changes due to physical activity in the elderly.
This is a 2021 ARVO Annual Meeting abstract.
Fig. 1 RTP, RBF, and tissue volume in the HSCT and CON groups at baseline and follow-up. a. In the HSCT group, RTP was significantly increased after 8-week training (P < 0.001), b. In the HSCT group, RBF was significantly increased at the follow-up (P < 0.001). c. there was no change in the tissue volume (P = 0.90) in the HSCT group.
Fig. 2 The changes in cognitive performances for each subject in the HSCT group and CON group before and after 8-week training. a. The changes in PAT scores at baseline and follow-up for each subject in the HSCT group. b. The changes in FCS scores at baseline and follow-up for each subject in the HSCT group. c. The changes in PAT scores at baseline and follow-up for each subject in the CON group. d. The changes in FCS scores at baseline and follow-up for each subject n the CON group.
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