June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Comparison of retinal pigment epithelium elevation between scans acquired at 200 kHz and 100 kHz rates
Author Affiliations & Notes
  • Shruti More
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Sophie Kubach
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Giovanni Gregori
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Mengxi Shen
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Liang Wang
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Xiaoshuang Jiang
    Sichuan University West China Hospital Department of Ophthalomology, Chengdu, Sichuan, China
  • Rita Laiginhas
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • yingying shi
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Luis De Sisternes
    Carl Zeiss Meditec Inc, Dublin, California, United States
  • Philip J Rosenfeld
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Footnotes
    Commercial Relationships   Shruti More, Carl Zeiss Meditec (E); Sophie Kubach, Carl Zeiss Meditec (E); Giovanni Gregori, Carl Zeiss Meditec (F); Mengxi Shen, None; Liang Wang, None; Xiaoshuang Jiang, None; Rita Laiginhas, None; yingying shi, None; Luis De Sisternes, Carl Zeiss Meditec (E); Philip Rosenfeld, Carl Zeiss Meditec (F), Carl Zeiss Meditec, Inc (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2529. doi:
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      Shruti More, Sophie Kubach, Giovanni Gregori, Mengxi Shen, Liang Wang, Xiaoshuang Jiang, Rita Laiginhas, yingying shi, Luis De Sisternes, Philip J Rosenfeld; Comparison of retinal pigment epithelium elevation between scans acquired at 200 kHz and 100 kHz rates. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2529.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography (OCT) angiography scans can be acquired at different scan rates. With faster scan rates becoming more prevalent, clinicians are expecting the most common OCT metrics to be available regardless of the rate at which these scans are acquired. The purpose of this study is to compare measurements of retinal pigment epithelium (RPE) elevation obtained on a swept-source OCT instrument at two different scan rates: 100 kHz and 200 kHz.

Methods : In this study, 25 dry AMD eyes were imaged on the swept-source OCT, PLEX® Elite 9000 (ZEISS, Dublin, CA) using 6×6 mm angiography scans. The acquisition consisted of 3 repeated scans at 200 kHz and 1 single scan at 100 kHz. The RPE elevations were computed over 3 mm and 5 mm circular areas and volumes centered on the fovea. The RPE elevation values from the scans acquired at both scan rates were plotted against each other. Linear regression was applied to the data to determine the R-squared value. The Bland-Altman analysis was used to determine the mean offset in RPE elevation measurements between the two scan rates. Paired t-tests were also calculated.

Results : The correlation plots (figures 1 and 2) show very good correlations (R2 > 0.98) in area and volume of RPE elevation between 100 kHz and 200 kHz scan rate. The p-values from a paired t-test were all well above 0.05 (p = 0.47 and p = 0.73 for the area of RPE elevation computed over 3 mm2 and 5 mm2 circles respectively; p = 0.17 and p = 0.36 for the volume of RPE elevation computed over 3 mm3 and 5 mm3 circles respectively) indicating no statistical difference in measurement difference between the 2 scan rates.

Conclusions : Based on these results, there is very good agreement in the RPE elevation measurements between 100 kHz and 200 kHz scan rate. Therefore, the current RPE elevation measurements obtained at 100 kHz are also applicable at 200 kHz.

This is a 2021 ARVO Annual Meeting abstract.

 

Figure 1: Linear regression and Bland-Altman Plot of RPE elevation values over a 3 mm2 (top 2) & 5 mm2 (bottom 2) circular area centered on the fovea acquired at 100 kHz versus 200 kHz

Figure 1: Linear regression and Bland-Altman Plot of RPE elevation values over a 3 mm2 (top 2) & 5 mm2 (bottom 2) circular area centered on the fovea acquired at 100 kHz versus 200 kHz

 

Figure 2: Linear regression and Bland-Altman Plot of RPE elevation values over a 3 mm3 (top 2) & 5 mm3 (bottom 2) circular volume centered on the fovea acquired at 100 kHz versus 200 kHz

Figure 2: Linear regression and Bland-Altman Plot of RPE elevation values over a 3 mm3 (top 2) & 5 mm3 (bottom 2) circular volume centered on the fovea acquired at 100 kHz versus 200 kHz

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