June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Impact of Slab Selection on the Relationship between Choriocapillaris Flow Deficits and Enlargement Rate of Geographic Atrophy.
Author Affiliations & Notes
  • Ahmed Roshdy Alagorie
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
    Tanta University, Tanta, Egypt
  • Giulia Corradetti
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Iksoo Byon
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Liran Tiosano
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Yongsok Ji
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Muneeswar Gupta Nittala
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Swetha Velaga
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Marco Nassisi
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Srinivas R Sadda
    Doheny Eye Institute Doheny Image Reading Center, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Ahmed Roshdy Alagorie, None; Giulia Corradetti, None; Iksoo Byon, None; Liran Tiosano, None; Yongsok Ji, None; Muneeswar Gupta Nittala, None; Swetha Velaga, None; Marco Nassisi, None; Srinivas Sadda, Allergan (C), Carl Zeiss Meditec (F), Centervue (C), Genentech (F), Heidelberg (C), Iconic (C), NightstarX (C), Novartis (C), Optos (F), Oxurion (C), Topcon (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2466. doi:
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      Ahmed Roshdy Alagorie, Giulia Corradetti, Iksoo Byon, Liran Tiosano, Yongsok Ji, Muneeswar Gupta Nittala, Swetha Velaga, Marco Nassisi, Srinivas R Sadda; Impact of Slab Selection on the Relationship between Choriocapillaris Flow Deficits and Enlargement Rate of Geographic Atrophy.. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2466.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To assess the impact of slab selection on the correlation between choriocapillaris (CC) flow deficits percentage (FD%) in eyes with geographic atrophy (GA) and the yearly enlargement rate (yER) of GA.

Methods : In this retrospective study, spectral domain optical coherence tomography (SD-OCT) and SD-OCT angiography (OCTA) images acquired on the Cirrus HD-OCT device (Carl Zeiss Meditec, Dublin, CA) were collected from patients with GA. Each patient underwent a 6x6 mm OCTA scan at baseline and two 6x6 mm structural SD-OCT volume scans, one at baseline and one after a minimum of 12 months. The edge of the GA lesion was delineated on the en face OCT fundus image and the yER was calculated after square root transformation. OCTA images were generated from three 10 µm thick slabs 11, 21 and 31 µm posterior to the RPE-fit line. A grid composed of 100 µm wide concentric rings was created around the GA on the compensated OCTA CC image and the FD% was calculated. FD% from each ring was correlated with the yER of GA. This was repeated for OCTA images from the different slab positions.

Results : Twenty-nine eyes of 22 patients were included in the study. For the 11-21 µm slab, the FD% was not significantly correlated with the yER for any of the evaluated rings. For the 21-31 and 31-41 µm slab, the FD% in the first five rings (from 0 to 500 µm from the border of GA) was significantly correlated with the yER. In all slab locations, there was no statistically significant correlation between the yER and CC FD% beyond 500 µm from the GA lesion.

Conclusions : Slab selection for quantification of CC FD% may have a significant impact on quantitative results and the correlation with other parameters of interest in eyes with GA.

This is a 2021 ARVO Annual Meeting abstract.

 

Geographic atrophy (GA) lesion was manually segmented on the en face OCT fundus image (A) and progressive 100 µm wide concentric rings were created around the GA margin using ImageJ. The resultant rings grid was applied to OCTA en face 6x6 mm slab of the choriocapillaris (B) at the same locations to calculate the flow deficit percentage (FD%) in each ring.

Geographic atrophy (GA) lesion was manually segmented on the en face OCT fundus image (A) and progressive 100 µm wide concentric rings were created around the GA margin using ImageJ. The resultant rings grid was applied to OCTA en face 6x6 mm slab of the choriocapillaris (B) at the same locations to calculate the flow deficit percentage (FD%) in each ring.

 

OCTA en face 6x6 mm slab of choriocapillaris (CC) exported from three different slab locations. The inner and outer boundaries of the CC slab were adjusted relative to the RPE fit reference to generate three different axial positions; 11-21 μm (A), 21-31 μm (B) and 31-41 μm (C) from the RPE band centerline.

OCTA en face 6x6 mm slab of choriocapillaris (CC) exported from three different slab locations. The inner and outer boundaries of the CC slab were adjusted relative to the RPE fit reference to generate three different axial positions; 11-21 μm (A), 21-31 μm (B) and 31-41 μm (C) from the RPE band centerline.

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