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Jacqueline Chua, Thu-Thao Le, Bingyao Tan, Ecosse Lamoureux, Calvin Woon Loong Chin, Tien Y Wong, Leopold Schmetterer; Choriocapillaris microvasculature dysfunction in systemic hypertension. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2463.
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The choriocapillaris layer in the eye is one of the densest layers of capillary vasculature in humans and may be affected by early microvascular changes as a result of uncontrolled systemic hypertension. To examine the choriocapillaris microvasculature using a non-invasive swept-source optical coherence tomography angiography (SS-OCTA) in healthy controls and hypertensive patients and determined possible correlations with BP and renal parameters.
A prospective study of 41 healthy controls and 71 hypertensive patients with varying blood pressure (BP) control. BP levels, serum creatinine and urine microalbumin/creatinine ratio (MCR) specimens were collected. The estimated glomerular filtration rate (eGFR) was calculated based on CKD-EPI Creatinine Equation. The main outcome was choriocapillaris flow deficits (CFD) metrics (density, size and numbers).
The CFD occupied a larger area and were fewer in number in the hypertensive patients with poor BP control (407 + 10 µm2; 3260 + 61) compared to the hypertensives with good BP control (369 + 5 µm2; 3551 + 41) and healthy controls (365 + 11 µm2; 3581 + 84). Higher systolic BP (β=9.90, 95% CI, 2.86 to 16.93), lower eGFR (β = -0.85; 95% CI, -1.58 to -0.13) and higher urine MCR (β=1.53, 95%CI, 0.32 to 2.78) were associated with larger areas of CFD. Similar significant associations with systolic BP, eGFR and urine MCR were found with number of CFD.
These findings highlight the potential role of choriocapillaris imaging using SS-OCTA as an indicator of systemic microvascular abnormalities secondary to hypertensive disease.
This is a 2021 ARVO Annual Meeting abstract.
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