June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Understanding patterns of glaucomatous progression in the macula using OCT thickness change maps
Author Affiliations & Notes
  • Sol La Bruna
    Department of Psychology, Columbia University, New York, New York, United States
  • Emmanouil (Manos) Tsamis
    Department of Psychology, Columbia University, New York, New York, United States
  • Jennifer Grossman
    Department of Psychology, Columbia University, New York, New York, United States
  • C Gustavo De Moraes
    Department of Ophthalmology, Columbia University Irving Medical Center, New York, New York, United States
  • Donald C Hood
    Department of Psychology, Columbia University, New York, New York, United States
    Department of Ophthalmology, Columbia University Irving Medical Center, New York, New York, United States
  • Footnotes
    Commercial Relationships   Sol La Bruna, None; Emmanouil (Manos) Tsamis, None; Jennifer Grossman, None; C Gustavo De Moraes, Carl Zeiss Meditec (C), Galimedix (C), Heidelberg Engineering (R), Novartis (C), Perfuse Therapeutics (C), Topcon (F); Donald Hood, Heidelberg Engineering (F), Heidelberg Engineering (R), Novartis (F), Novartis (R), Topcon (F), Topcon (R)
  • Footnotes
    Support  NIH Grant EY002115 and EY025253
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1821. doi:
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    • Get Citation

      Sol La Bruna, Emmanouil (Manos) Tsamis, Jennifer Grossman, C Gustavo De Moraes, Donald C Hood; Understanding patterns of glaucomatous progression in the macula using OCT thickness change maps. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1821.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify and understand patterns of progressive thinning in the macular ganglion cell layer (GCL) using spectral domain OCT thickness change maps of the GCL and retinal nerve fiber layer (RNFL).

Methods : 114 glaucoma, glaucoma suspect, and healthy (HC) eyes from 114 individuals had OCT scans and 24-2 and 10-2 visual fields (VFs) as part of a longitudinal, prospective study. Based upon an evaluation of all available OCT and 24-2 and 10-2 VF information, 12 eyes were classified as definite Progressors (P), and 67 as definite non-progressors (NP). OCT thickness change maps of the RNFL and GCL were generated from manually corrected OCT volume scans (30°x25°), by comparing the most recent follow-up to the baseline test (avg. 3.1 yrs apart).

Results : In 6 of the 12 P eyes arcuate shaped regions of progression (Fig. 1A) were visible on GCL, as well as RNFL, thickness change maps. In the other 6 eyes, diffuse regions of progression (Fig. 1B) were visible on GCL, while the RNFL, thickness change maps showed a combination of diffuse and arcuate regions of progression. Healthy controls showed little or no consistent arcuate or diffuse patterns on the RNFL or GCL change maps. (See comparison of maps for HC and P with diffuse changes in Fig. 2.)

Conclusions : Macular progression involves both deep local and shallow widespread thinning in the GCL. Change maps of the RNFL and the GCL can aid in the identification of glaucomatous progression.

This is a 2021 ARVO Annual Meeting abstract.

 

 

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