Investigative Ophthalmology & Visual Science Cover Image for Volume 62, Issue 8
June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Changes in Pupillary Light Reflex Metrics in Proliferative Diabetic Retinopathy
Jessica June Wang; Minnah Ahn; Anderson N. Vu; Josiah K. To; Andrew W Browne
Author Affiliations & Notes
  • Jessica June Wang
    University of California Irvine School of Medicine, Irvine, California, United States
  • Minnah Ahn
    University of California Irvine School of Medicine, Irvine, California, United States
  • Anderson N. Vu
    Gavin Herbert Eye Institute, Department of Ophthalmology, University of California Irvine School of Medicine, Irvine, California, United States
  • Josiah K. To
    Gavin Herbert Eye Institute, Department of Ophthalmology, University of California Irvine School of Medicine, Irvine, California, United States
  • Andrew W Browne
    Gavin Herbert Eye Institute, Department of Ophthalmology, University of California Irvine School of Medicine, Irvine, California, United States
    Department of Biomedical Engineering, Institute for Clinical and Translational Science, University of California Irvine, Irvine, California, United States
  • Footnotes
    Commercial Relationships   Jessica Wang, None; Minnah Ahn, None; Anderson Vu, None; Josiah To, None; Andrew Browne, None
  • Footnotes
    Support  This project was supported by an RPB unrestricted grant to UCI Department of Ophthalmology and a UCI ICTS NIH KL2 Grant number is KL2 TR001416.
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 3627. doi:
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      Jessica June Wang, Minnah Ahn, Anderson N. Vu, Josiah K. To, Andrew W Browne; Changes in Pupillary Light Reflex Metrics in Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2021;62(8):3627.

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Abstract

Purpose : Although some investigations have examined the pathologic effects of proliferative diabetic retinopathy (PDR) on the pupillary light reflex (PLR), effects on both the direct and consensual reflex have not been fully explored. This prospective clinical study examines the effects of PDR on the direct and consensual PLR using a clinically marketed objective pupillometer not previously studied in this population. We hypothesize that diabetic retinal changes will decrease constriction amplitude absolute value and change (Ac and Ac%), velocity of constriction (Vc), and velocity of re-dilation (Vr), while prolonging latency of onset of constriction (Loc) and maximal constriction (Lmaxc).

Methods : PLR metrics of 28 right eyes (15 healthy control, 13 with PDR) were measured with the EyeKinetix Objective Pupillometer (Konan Medical, Irvine, California USA) during normal course of care in a retina clinic. Patients diagnosed with PDR were included in the experimental group. Patients with glaucoma or suspect at examination were excluded. Statistical analysis was completed using independent samples t-test.

Results : Ac, Ac%, Vc, and Vr were significantly decreased compared to the control group. Loc and Lmaxc were increased but the change was statistically non-significant.

Conclusions : This data further reinforces that pathologic changes in PDR affect pathways in the PLR. Therefore, complete quantitative characterization of PLR with pupillography metrics may be a valuable biomarker for evaluating ophthalmic disease activity in diabetic patients.

This is a 2021 ARVO Annual Meeting abstract.

 

Table 1. Mean pupillography metrics
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Table 1. Mean pupillography metrics

Table 1. Mean pupillography metrics

Table 1. Mean pupillography metrics
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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