Abstract
Purpose :
To evaluate the short-term effect of dexmethylphenidate (D-MPH) on visual acuity, pupil size, anterior chamber depth (ACD), and accommodation-convergence reflex in children treated with D-MPH XR for attention-deficit/hyperactivity disorder (ADHD).
Methods :
Prospective cohort study including 15 patients aged 8-16 (11.58±2.39) treated with D-MPH for ADHD. Patients were questioned for subjective complains such as blurred vision and photosensitivity. Ophthalmic evaluation was performed twice; prior to and 1.5 hours following D-MPH administration. The exam included evaluation of best corrected visual acuity at distance and near, accommodation range, convergence range, 3-D vision test and anterior chamber optical coherence tomography (OCT).
Results :
A significant association between pupil diameter and D-MPH treatment dose was demonstrated (p=0.001). Additionally, a positive correlation between complains about blurred vision and D-MPH daily dosage was found. There were no significant changes in visual acuity, convergence range, stereo vision, accommodation range, or anterior chamber measures.
Conclusions :
Our findings provide further support to the effect of stimulants on pupil diameter, as well as on subjective complains about blurred vision in a dose dependent manner. Additionally, future research is required to further investigate a potential role for pupil diameter as a marker of response to D-MPH.
This is a 2021 ARVO Annual Meeting abstract.