June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes
Takashi Nishida; Sasan Moghimi; Huiyuan Hou; James A Proudfoot; Ryan Caezar Calaguas David; Alireza Kamalipour; Nevin W. El-Nimri; Christopher Bowd; Jasmin Rezapour; Linda M Zangwill; Robert N Weinreb
Author Affiliations & Notes
  • Takashi Nishida
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Sasan Moghimi
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Huiyuan Hou
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • James A Proudfoot
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Ryan Caezar Calaguas David
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Alireza Kamalipour
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Nevin W. El-Nimri
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Christopher Bowd
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Jasmin Rezapour
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Linda M Zangwill
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Robert N Weinreb
    University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, La Jolla, California, United States
  • Footnotes
    Commercial Relationships   Takashi Nishida, None; Sasan Moghimi, None; Huiyuan Hou, None; James Proudfoot, None; Ryan Caezar David, None; Alireza Kamalipour, None; Nevin El-Nimri, None; Christopher Bowd, None; Jasmin Rezapour, None; Linda Zangwill, Carl Zeiss Meditec Inc. (F), Heidelberg Engineering GmbH (F), Optovue Inc. (F), Topcon Medical Systems Inc. (F), Zeiss Meditec (P); Robert Weinreb, Allergan (C), Bausch&Lomb (C), Bausch&Lomb (F), Carl Zeiss Meditec (F), Centervue (F), Eyenovia (C), Heidelberg Engineering (F), Konan Medical (F), Meditec-Zeiss (P), Optovue (F), Toromedes (P)
  • Footnotes
    Support  NEI R01EY029058, R01EY11008, R01EY19869, P30EY022589, R01EY026574, R01EY027510, German Research Foundation (DFG, research fellowship grant RE 4155/1-1), Tobacco-Related Disease Research Program T31IP1511, and Unrestricted grant from Research to Prevent Blindness (New York, NY)
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1855. doi:
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      Takashi Nishida, Sasan Moghimi, Huiyuan Hou, James A Proudfoot, Ryan Caezar Calaguas David, Alireza Kamalipour, Nevin W. El-Nimri, Christopher Bowd, Jasmin Rezapour, Linda M Zangwill, Robert N Weinreb; Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1855.

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Abstract

Purpose : To assess and compare long-term reproducibility of optical coherence tomography angiography (OCTA) vascular parameters and spectral-domain optical coherence tomography (OCT) thickness parameters in stable glaucoma, glaucoma suspect, and healthy eyes.

Methods : A total of 88 eyes (15 healthy, 38 glaucoma suspect, and 35 non-progressive POAG) of 68 subjects were enrolled who had at least 3 visits within 1 to 1.5 years and both OCT and OCTA (Optovue Inc, Fremont, California, USA) imaging on the same day. A series of vascular and thickness parameters were measured including macula whole image vessel density (wiVD), optic nerve head (ONH) circumpapillary capillary density (cpCD), macular whole image ganglion cell complex (wiGCC) and circumpapillary retinal nerve fiber layer (cpRNFL). Non-progressive POAG eyes were defined using Guided Progression Analysis software (Carl Zeiss Meditec, Inc., Dublin, CA) and fundus photos performed (minimum follow-up of 5 years). A random effects analysis of variance model was used to estimate intraclass correlation (ICC) coefficients and long-term variability estimates. Intra-class correlation (ICC), root mean squared error (RMSE), within-subject test-retest standard deviation (Sw), and coefficient of variation (CV) analyses were obtained to determine long-term reproducibility of OCTA and OCT measurements.

Results : No significant cpRNFL thinning, cpC loss or pfVD loss was observed (p=0.137, p=0.137, and p=0.094, respectively), while pfGCC thinning was detectable over time (p<0.001). ICC was lower for OCTA (pfVD 0.823 (95% confidence interval: 0.736, 0.888) and cpCD 0.871 (0.818, 0.912)) compared to OCT (pfGCC 0.995 (0.993, 0.997) and cpRNFL 0.975 (0.964, 0.984)). RMSE was 1.43 and 1.41 for pfVD and cpCD, and 0.65 and 1.41 for pfGCC and cpRNFL. Sw was 1.17 and 1.22 for pfVD and cpCD, and 0.57 and 1.22 for pfGCC and cpRNFL. CV was higher for OCTA parameters (pfVD 2.48 and cpCD 2.61) compared to OCT parameters (pfGCC 0.56 and cpRNFL 1.79).

Conclusions : OCTA-measured macula and ONH vascular parameters have good long-term reproducibility, supporting the use of this instrument for longitudinal analysis. OCTA long-term reproducibility is lower than OCT measured thickness parameters.

This is a 2021 ARVO Annual Meeting abstract.

 

Reproducibility Measurements for OCTA and OCT parameters
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Reproducibility Measurements for OCTA and OCT parameters

Reproducibility Measurements for OCTA and OCT parameters

Reproducibility Measurements for OCTA and OCT parameters
View OriginalDownload Slide

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2024 Association for Research in Vision and Ophthalmology.
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