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Takashi Nishida, Sasan Moghimi, Huiyuan Hou, James A Proudfoot, Ryan Caezar Calaguas David, Alireza Kamalipour, Nevin W. El-Nimri, Christopher Bowd, Jasmin Rezapour, Linda M Zangwill, Robert N Weinreb; Long-Term Reproducibility of Optical Coherence Tomography Angiography in Stable Glaucomatous Eyes. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1855.
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© ARVO (1962-2015); The Authors (2016-present)
To assess and compare long-term reproducibility of optical coherence tomography angiography (OCTA) vascular parameters and spectral-domain optical coherence tomography (OCT) thickness parameters in stable glaucoma, glaucoma suspect, and healthy eyes.
A total of 88 eyes (15 healthy, 38 glaucoma suspect, and 35 non-progressive POAG) of 68 subjects were enrolled who had at least 3 visits within 1 to 1.5 years and both OCT and OCTA (Optovue Inc, Fremont, California, USA) imaging on the same day. A series of vascular and thickness parameters were measured including macula whole image vessel density (wiVD), optic nerve head (ONH) circumpapillary capillary density (cpCD), macular whole image ganglion cell complex (wiGCC) and circumpapillary retinal nerve fiber layer (cpRNFL). Non-progressive POAG eyes were defined using Guided Progression Analysis software (Carl Zeiss Meditec, Inc., Dublin, CA) and fundus photos performed (minimum follow-up of 5 years). A random effects analysis of variance model was used to estimate intraclass correlation (ICC) coefficients and long-term variability estimates. Intra-class correlation (ICC), root mean squared error (RMSE), within-subject test-retest standard deviation (Sw), and coefficient of variation (CV) analyses were obtained to determine long-term reproducibility of OCTA and OCT measurements.
No significant cpRNFL thinning, cpC loss or pfVD loss was observed (p=0.137, p=0.137, and p=0.094, respectively), while pfGCC thinning was detectable over time (p<0.001). ICC was lower for OCTA (pfVD 0.823 (95% confidence interval: 0.736, 0.888) and cpCD 0.871 (0.818, 0.912)) compared to OCT (pfGCC 0.995 (0.993, 0.997) and cpRNFL 0.975 (0.964, 0.984)). RMSE was 1.43 and 1.41 for pfVD and cpCD, and 0.65 and 1.41 for pfGCC and cpRNFL. Sw was 1.17 and 1.22 for pfVD and cpCD, and 0.57 and 1.22 for pfGCC and cpRNFL. CV was higher for OCTA parameters (pfVD 2.48 and cpCD 2.61) compared to OCT parameters (pfGCC 0.56 and cpRNFL 1.79).
OCTA-measured macula and ONH vascular parameters have good long-term reproducibility, supporting the use of this instrument for longitudinal analysis. OCTA long-term reproducibility is lower than OCT measured thickness parameters.
This is a 2021 ARVO Annual Meeting abstract.
Reproducibility Measurements for OCTA and OCT parameters
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