June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Intrasession Repeatability and Intersession Reproducibility of Macular Vessel Parameters by Optical Coherence Tomography Angiography
Alexander Vorperian; Nasir Khan; Jae Lee; Bruce Burkemper; Xiao Zhou; Dominic Joseph Grisafe; Vivian LeTran; Zhongdi Chu; Brian Song; Brandon Wong; Benjamin Yixing Xu; Ruikang K Wang; Grace Richter
Author Affiliations & Notes
  • Alexander Vorperian
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Nasir Khan
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Jae Lee
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Bruce Burkemper
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Xiao Zhou
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Dominic Joseph Grisafe
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Vivian LeTran
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Zhongdi Chu
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Brian Song
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Brandon Wong
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Benjamin Yixing Xu
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Ruikang K Wang
    Department of Bioengineering, University of Washington, Seattle, Washington, United States
  • Grace Richter
    USC Roski Eye Institute, University of Southern California Keck School of Medicine, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Alexander Vorperian, None; Nasir Khan, None; Jae Lee, None; Bruce Burkemper, None; Xiao Zhou, None; Dominic Grisafe, None; Vivian LeTran, None; Zhongdi Chu, None; Brian Song, None; Brandon Wong, None; Benjamin Xu, None; Ruikang Wang, Carl Zeiss Meditec (C), Carl Zeiss Meditec (P), Carl Zeiss Meditec (F); Grace Richter, Carl Zeiss Meditec (F)
  • Footnotes
    Support  5K23EY027855-03
Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1826. doi:
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      Alexander Vorperian, Nasir Khan, Jae Lee, Bruce Burkemper, Xiao Zhou, Dominic Joseph Grisafe, Vivian LeTran, Zhongdi Chu, Brian Song, Brandon Wong, Benjamin Yixing Xu, Ruikang K Wang, Grace Richter; Intrasession Repeatability and Intersession Reproducibility of Macular Vessel Parameters by Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1826.

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Abstract

Purpose : Using optical coherence tomography angiography (OCTA), this study seeks to compare intrasession repeatability and intersession reproducibility of macular vessel parameters in glaucoma and non-glaucoma subjects.

Methods : A series of 6x6mm macular optical coherence tomography angiography scans (Cirrus HD-OCT 5000) were acquired from both glaucomatous and non-glaucomatous subjects as part of an observational, longitudinal study. Next, vessel area density (VAD), vessel skeleton density (VSD), and flux were calculated using a research-based quantification software. Additionally, perfusion density (PDZ) and vessel density (VDZ) were calculated using commercially developed software (Cirrus 11.0, Carl Zeiss Meditec). Finally, the intrasession repeatability and intersession reproducibility of these macular parameters were determined using the following statistical parameters: within-eye standard deviation (SW), within-eye coefficient of repeatability (CRW), within-eye coefficient of variation (CVW), and intraclass correlation coefficients (ICC).

Results : The intrasession CVW from the non-glaucoma group (n=75) was 1.466 for VAD, 1.150 for VSD, 5.203 for PDZ, and 4.836 for VDZ while the intersession CVW from the non-glaucoma group (n=53) was 2.245 for VAD, 1.411 for VSD, 6.971 for PDZ, and 6.564 for VDZ. The intrasession CVW from the glaucoma group (n=60) was 1.294 for VAD, 1.006 for VSD, 4.910 for PDZ, and 4.516 for VDZ while the intersession CVW from the glaucoma group (n=40) was 1.899 for VAD, 1.228 for VSD, 5.858 for PDZ, and 5.532 for VDZ. Non-glaucomatous intrasession ICC ranged from 0.561 for PDZ to 0.795 for VAD while non-glaucomatous intersession ICC ranged from 0.334 for PDZ to 0.740 for VSD. Glaucomatous intrasession ICC ranged from 0.728 for PDZ to 0.894 for VAD while glaucomatous intersession ICC ranged from 0.541 for PDZ to 0.780 for VSD.

Conclusions : Macular OCTA parameters had greater intrasession repeatability than intersession reproducibility for both glaucomatous and non-glaucomatous eyes. Additionally, the macular parameters analyzed by the research-based software demonstrated higher repeatability than the commercial parameters across both non-glaucomatous and glaucomatous eyes.

This is a 2021 ARVO Annual Meeting abstract.

 

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