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Alexander Vorperian, Nasir Khan, Jae Lee, Bruce Burkemper, Xiao Zhou, Dominic Joseph Grisafe, Vivian LeTran, Zhongdi Chu, Brian Song, Brandon Wong, Benjamin Yixing Xu, Ruikang K Wang, Grace Richter; Intrasession Repeatability and Intersession Reproducibility of Macular Vessel Parameters by Optical Coherence Tomography Angiography. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1826.
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© ARVO (1962-2015); The Authors (2016-present)
Using optical coherence tomography angiography (OCTA), this study seeks to compare intrasession repeatability and intersession reproducibility of macular vessel parameters in glaucoma and non-glaucoma subjects.
A series of 6x6mm macular optical coherence tomography angiography scans (Cirrus HD-OCT 5000) were acquired from both glaucomatous and non-glaucomatous subjects as part of an observational, longitudinal study. Next, vessel area density (VAD), vessel skeleton density (VSD), and flux were calculated using a research-based quantification software. Additionally, perfusion density (PDZ) and vessel density (VDZ) were calculated using commercially developed software (Cirrus 11.0, Carl Zeiss Meditec). Finally, the intrasession repeatability and intersession reproducibility of these macular parameters were determined using the following statistical parameters: within-eye standard deviation (SW), within-eye coefficient of repeatability (CRW), within-eye coefficient of variation (CVW), and intraclass correlation coefficients (ICC).
The intrasession CVW from the non-glaucoma group (n=75) was 1.466 for VAD, 1.150 for VSD, 5.203 for PDZ, and 4.836 for VDZ while the intersession CVW from the non-glaucoma group (n=53) was 2.245 for VAD, 1.411 for VSD, 6.971 for PDZ, and 6.564 for VDZ. The intrasession CVW from the glaucoma group (n=60) was 1.294 for VAD, 1.006 for VSD, 4.910 for PDZ, and 4.516 for VDZ while the intersession CVW from the glaucoma group (n=40) was 1.899 for VAD, 1.228 for VSD, 5.858 for PDZ, and 5.532 for VDZ. Non-glaucomatous intrasession ICC ranged from 0.561 for PDZ to 0.795 for VAD while non-glaucomatous intersession ICC ranged from 0.334 for PDZ to 0.740 for VSD. Glaucomatous intrasession ICC ranged from 0.728 for PDZ to 0.894 for VAD while glaucomatous intersession ICC ranged from 0.541 for PDZ to 0.780 for VSD.
Macular OCTA parameters had greater intrasession repeatability than intersession reproducibility for both glaucomatous and non-glaucomatous eyes. Additionally, the macular parameters analyzed by the research-based software demonstrated higher repeatability than the commercial parameters across both non-glaucomatous and glaucomatous eyes.
This is a 2021 ARVO Annual Meeting abstract.
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