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Masahiro Miura, Shuichi Makita, Yoshiaki Yasuno, Takuya Iwasaki, Shinnosuke Azuma, Toshihiro Mino, Tatsuo Yamaguchi; Choroidal melanin thickness measurement in healthy Japanese subjects by polarization-sensitive optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1376.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate choroidal melanin distribution in healthy subjects by polarization-sensitive optical coherence tomography (PS-OCT).
This study involved 57 eyes of 57 healthy Japanese subjects. The presence of melanin in the choroid was determined by using the degree of polarization uniformity (DOPU) obtained by 1 μm Jones-matrix PS-OCT. Choroidal melanin thickness was evaluated for 5 mm circular region from the foveal center, and compared with age (26 – 84 years), axial length (22.0 – 28.5 mm), choroidal thickness, and choroidal luminal/stromal ratio. To evaluate the distribution of choroidal melanin thickness, circular region was divided into five sectors (center, upper, lower, nasal, and temporal) by modified ETDRS layout.
The mean choroidal thickness and choroidal melanin thickness (mean ± SD) at 5 mm circular region were 202.5 ± 80.8 μm and 68.3 ± 24.2 μm, respectively. Mean choroidal thickness showed significant negative correlation with age (β = -0.30, P = 0.004) and axial length (b = -0.21, P = 0.03), and significant positive correlation with luminal/stromal ratio (β = 0.62, P < 0.001). Mean choroidal melanin thickness showed significant negative correlation with axial length (β = -0.26, P = 0.045) and luminal/stromal ratio (β = -0.60, P = 0.001), and significant positive correlation with choroidal thickness (β = 0.85, P < 0.001). The mean choroidal thickness and choroidal melanin thickness of the nasal sector were significantly thinner than that of all other sectors (P < 0.001).
PS-OCT provides an in vivo objective choroidal melanin distribution. Choroidal melanin thickness varies significantly with location, axial length, and choroidal morphology.
This is a 2021 ARVO Annual Meeting abstract.
Representative case of choroidal melanin distribution (right eye of 34 years old male).
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