June 2021
Volume 62, Issue 8
Open Access
ARVO Annual Meeting Abstract  |   June 2021
Retina Vascular Structures Near the Optic Disc and in the Macula in Primary Angle Closure Suspects
Author Affiliations & Notes
  • Merry Ruan
    University of California San Francisco, San Francisco, California, United States
  • Xiaohua Pan
    Beijing Tongren Hospital, Beijing, Beijing, China
  • Wudi Fan
    University of California Berkeley, Berkeley, California, United States
  • Kai Cao
    Beijing Tongren Hospital, Beijing, Beijing, China
  • Hui Feng
    Beijing Tongren Hospital, Beijing, Beijing, China
  • Zhongyin Hu
    First People's Hospital of Yunnan, Kunming, Yunnan, China
  • Yue Yang
    Sichuan Mental Health Center, China
  • Fancheng Yan
    Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, Beijing, China
  • Mengya Zhao
    Shanghai General Hospital, China
  • Qian Liu
    Henan Eye Hospital, China
  • Min Fu
    Southern Medical University, Guangzhou, Guangdong, China
  • Richard K Lee
    University of Miami Health System Bascom Palmer Eye Institute, Miami, Florida, United States
  • Shuning Li
    Beijing Tongren Hospital, Beijing, Beijing, China
  • Ying Han
    University of California San Francisco, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Merry Ruan, None; Xiaohua Pan, None; Wudi Fan, None; Kai Cao, None; Hui Feng, None; Zhongyin Hu, None; Yue Yang, None; Fancheng Yan, None; Mengya Zhao, None; Qian Liu, None; Min Fu, None; Richard Lee, None; Shuning Li, None; Ying Han, None
  • Footnotes
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Investigative Ophthalmology & Visual Science June 2021, Vol.62, 1023. doi:
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      Merry Ruan, Xiaohua Pan, Wudi Fan, Kai Cao, Hui Feng, Zhongyin Hu, Yue Yang, Fancheng Yan, Mengya Zhao, Qian Liu, Min Fu, Richard K Lee, Shuning Li, Ying Han; Retina Vascular Structures Near the Optic Disc and in the Macula in Primary Angle Closure Suspects. Invest. Ophthalmol. Vis. Sci. 2021;62(8):1023.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To study the retinal peri-papillary and macular vascular structures in eyes of primary angle closure suspects (PACS)

Methods : Control and PACS subjects were recruited from a community screening. Only one eye per subject was used for analysis. All participants underwent a questionnaire survey, physical and ophthalmic examinations, ocular biometry measurements, and optical coherence tomography angiography (OCTA). We compared basic demographics and vessel structure parameters between control and PACS eyes. Univariate and multivariate linear regression analysis were performed to investigate factors associated with vascular parameters in both groups.

Results : Data from 254 subjects including 155 PACS and 99 controls were analyzed. In the peri-papillary region, PACS eyes showed similar retina nerve fiber layer (RNFL) and vessel densities (VDs) including and excluding large vessels compared to control eyes. Compared to control eyes, all macular OCTA parameters showed significant differences in PACS eyes, including decreased superficial VD (mean=17.23 vs 13.80, p=0.006) and deep VD (mean=31.33 vs 27.92, p=0.004), larger fovea avascular zone (FAZ) area (mean=0.35 vs 0.39, p=0.006) and longer FAZ perimeter (mean=2.29 vs 2.45, p=0.004) . Gender (p=0.039), age (p<0.001), and Garway Heath (GH) superior hemisphere RNFL (p<0.001) were risk factors influencing optic disc VD excluding large vessels (Table 1). Axial length (AL) was the major factor affecting macula superficial and deep vessel densities (p=0.004 and 0.001 respectively), while PACS was independent factors associated with larger FAZ perimeter (p=0.046) (Table 2).

Conclusions : While PACS and control eyes have comparable RNFL and vascular structure around the optic nerve head, macular vascular structures are significantly different, which could precede clinical functional and structural abnormalities.

This is a 2021 ARVO Annual Meeting abstract.




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